Abstract:White fibrous papulosis of the neck is a rare entity, with a benign course and unknown pathogenesis. It is clinically characterized by the appearance of firm, persistent, usually asymptomatic, non-follicular papules located on the neck. We present the case of a 72-year-old patient who presented pruritic lesions on the neck whose biopsy was compatible with this entity.
“…To confirm the clinical diagnosis of WFPN, a biopsy is performed. It is characterized histologically by the presence of fibroelastolytic alterations in the papillary dermis, with a decrease or absence of elastic fibers [ 5 - 7 ]. Given that this condition impacts the neck, it is also imperative to differentiate WFPN as a benign ailment characterized by the absence of lymph node pathology [ 8 ].…”
Section: Discussionmentioning
confidence: 99%
“…These clinical features suggest the following differential diagnoses: PXE-PDE, PXE, acrochordons, fibrofolliculoma, trichodiscomas, Buschke-Ollendorff syndrome, and cutis rhomboidalis nuchae (Table 1) [2,4,5,[9][10][11][12][13]. PXE papules resemble WFPN owing to their white, discrete appearance, which can occasionally merge, creating a "cobblestone" or "chicken skin" texture [14].…”
White fibrous papulosis of the neck (WFPN) manifests through the presence of numerous solid, persistent, and asymptomatic yellowish-white papules, displaying a distinctive asymmetrical distribution primarily localized on the neck and antecubital fossa. This case report describes the clinical presentation of a 70-year-old female diagnosed with WFPN, highlighting the significant finding of collagen fiber thickening upon histopathological analysis. Despite its predilection for specific anatomical sites, the elusive pathogenesis of WFPN adds diagnostic complexity, emphasizing the need for further research in this unique condition that generally follows a benign course.
“…To confirm the clinical diagnosis of WFPN, a biopsy is performed. It is characterized histologically by the presence of fibroelastolytic alterations in the papillary dermis, with a decrease or absence of elastic fibers [ 5 - 7 ]. Given that this condition impacts the neck, it is also imperative to differentiate WFPN as a benign ailment characterized by the absence of lymph node pathology [ 8 ].…”
Section: Discussionmentioning
confidence: 99%
“…These clinical features suggest the following differential diagnoses: PXE-PDE, PXE, acrochordons, fibrofolliculoma, trichodiscomas, Buschke-Ollendorff syndrome, and cutis rhomboidalis nuchae (Table 1) [2,4,5,[9][10][11][12][13]. PXE papules resemble WFPN owing to their white, discrete appearance, which can occasionally merge, creating a "cobblestone" or "chicken skin" texture [14].…”
White fibrous papulosis of the neck (WFPN) manifests through the presence of numerous solid, persistent, and asymptomatic yellowish-white papules, displaying a distinctive asymmetrical distribution primarily localized on the neck and antecubital fossa. This case report describes the clinical presentation of a 70-year-old female diagnosed with WFPN, highlighting the significant finding of collagen fiber thickening upon histopathological analysis. Despite its predilection for specific anatomical sites, the elusive pathogenesis of WFPN adds diagnostic complexity, emphasizing the need for further research in this unique condition that generally follows a benign course.
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