“White dot syndromes”, an inappropriate and outdated misnomer

Neri, Piergiorgio; Herbort, Carl P.; Hedayatfar, Alireza; Tuğal-Tutkun, İlknur; Cimino, Luca; Urzua, Cristhian A.; Papasavvas, Ioannis; Takeuchi, Masuru; Lages, Vânia

doi:10.1007/s10792-021-02121-4

Cited by 9 publications

(7 citation statements)

References 18 publications

(8 reference statements)

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“…Meanwhile, it was pleasing to observe the sharp decline of the term KCOT, implying that in this case the healthcare academia largely and swiftly followed the latest changes in the nomenclature. This could have been difficult, considering that the terminology could be ingrained in researchers’ knowledge base, resurfacing from time to time as it was embedded in medical web search engines [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Radiolucent Lesions of the Jaws: An Attempted Demonstration of the Use of Co-Word Analysis to List Main Similar Pathologies

Yeung¹

2022

IJERPH

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(1) Background: Many radiolucent jaw lesions exist, and they often show a radiographic resemblance, rendering diagnosis a challenging act. Closely related lesions should be frequently mentioned together in the academic literature, which might be helpful for junior practitioners in determining their differential diagnosis. The usefulness of bibliometric analysis in this respect has yet to be demonstrated. (2) Methods: This study evaluated academic publications on radiolucent jaw lesions, as indexed by the Web of Science Core Collection database. The mentions of radiolucent jaw lesions were extracted from the complete bibliographic records of the publications, and co-word analyses were conducted with the aid of VOSviewer. (3) Results: Based on 1897 papers, visualization maps were synthesized to evaluate co-occurrences of the radiolucent jaw lesions. Ameloblastoma was frequently mentioned together with odontogenic keratocyst, dentigerous cyst, and radicular cyst. Osseous dysplasia was co-mentioned with osteomyelitis, ossifying fibroma, odontoma, fibrous dysplasia, and apical periodontitis. (4) Conclusions: The co-word analysis, a form of bibliometric analysis, could demonstrate a relatedness of radiolucent jaw lesions that could be considered at differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Radiolucent Lesions of the Jaws: An Attempted Demonstration of the Use of Co-Word Analysis to List Main Similar Pathologies

Yeung¹

2022

IJERPH

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“…A first attempt at classification was undertaken in 1995 under the terminology of "white dot syndromes" (WDS) [13]. This classification, simply based on similar fundus lesions, was not only inappropriate, but at the origin of much confusion during the three decades that followed by grouping diseases not belonging together [2].…”

Section: Clinicopathology Of Piccpsmentioning

confidence: 99%

“…Primary inflammatory choriocapillaropathies are a group of intraocular inflammatory diseases for which the site of inflammation is situated at the level of the choriocapillaris, producing choriocapillaris non-perfusion [1]. These conditions used to be included in the inappropriate and outdated misnomer of "white dot syndromes" including unrelated diseases and should be abandoned [2]. Depending on the extension and the sizes of capillary drop-outs, the spectrum of this group of diseases extends from benign and reversible, such as multiple evanescent white dot syndrome (MEWDS), to more severe involvement with non-reversible scars, such as acute multifocal placoid pigment epitheliopathy (APMPPE), idiopathic multifocal choroiditis (MFC) or serpiginous choroiditis (SC).…”

Section: Introductionmentioning

confidence: 99%

“…Beside these welldefined phenotypes, overlapping and intermediary forms, as well as mixed forms having the aspect of one entity with the evolution of another, are completing the spectrum. For more than two decades, these conditions were classified with other unrelated syndromes in the potpourri group of "white dot syndromes" [2,3]. On the reverse, PICCPs have a common denominator, choriocapillaris non-perfusion.…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis and Treatment of Primary Inflammatory Choriocapillaropathies (PICCPs): A Comprehensive Overview

Papasavvas¹,

Herbort²

2022

Medicina

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Purpose: Primary inflammatory choriocapillaropathies (PICCPs) belong to a group of intraocular inflammatory diseases with the common characteristic of inflammatory choriocapillaris hypo- or non-perfusion as the main clinicopathological mechanism. The purpose of our article is to describe clinical characteristics and multimodal imaging, that can help the diagnosis and treatment of PICCPs. Methods: Narrative review with multimodal imaging analysis. Results: Choriocapillaris non-perfusion can affect the end-choriocappilaries, at the benign end of the PICCP spectrum (MEWDS), to larger choriocapillaris vessels or precapillary vessels at the origin of more severe forms such as acute posterior multifocal placoid pigment epitheliopathy (APMPPE), idiopathic multifocal choroiditis (MFC) and Serpiginous Choroiditis (SC). Diagnosis is mostly based on multimodal imaging and especially on indocyanine green angiography (ICGA), fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT)/OCT-angiography (OCT-A). ICGA shows the typical pattern of patchy lobular hypofluorescence reflecting hypo- or non-perfusion of the choriocapillaris that can also take the aspect of geographic areas in the more severe forms. Treatment depends on the severity of the disease and goes from observation in MEWDS and some mild cases of APMPPE, to oral corticosteroid and/or immunomodulator agents in the more severe conditions of APMPPE and MFC and SC cases. Close multimodal monitoring is crucial in order to introduce or adjust treatment. Conclusion: PICCPs are resulting from one common clinicopathological mechanism, inflammatory choriocapillaris hypo- or non-perfusion. ICGA findings are essential for the diagnosis and follow-up of PICCPs, but non-invasive methods such as FAF and SD-OCT/OCT-A also have their role especially in follow-up of the diseases. Treatment should be individualized according to the pathology and the evolution of lesions.

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“…Central multifocal choroiditis (cMFC) is part of the spectrum of the white dot syndromes or more specifically of the group of primary inflammatory choriocapillaris [1]. cMFC is characterized by inflammation of the choriocapillaris resulting in the typical white dots in the fundus of the eye.…”

Section: Introductionmentioning

confidence: 99%

Idiopathic Multifocal Choroiditis and Punctate Inner Choroidopathy – Evaluation of Risk Factors for Increased Relapse Rate: A 2-Year Prospective Observational Cohort Study

Groot

Boer

Norel³

2022

Ophthalmologica

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Introduction The aim of this study is to describe the course of disease in patients with idiopathic multifocal choroiditis (MFC) and punctate inner choroidopathy (PIC) and to identify risk factors associated with an increased relapse rate of disease activity. Methods In this prospective observational cohort study, demographical and clinical data were collected concerning the relapses rate of disease activity, the conclusions of the multimodal imaging results, treatment, complications and self-reported quality of life. Disease activity was defined as new inflammatory lesions or active inflammation in pre-existing chorioretinal lesions either with or without active choroidal neovascularization (CNV). Linear regression analysis was performed to identify risk factors associated with an increased relapse rate. Results In total 122 eyes of 82 patients (93% females) were included with a median age (IQR) of 45 (37-54) years. A history of secondary CNV was present in 66% of the eyes. During follow-up the best-corrected visual acuity remained stable despite a median relapse rate (IQR) of 1.0 (0.25-3). Cycles of oral corticosteroids was given in 59% of the patients, 72% were treated at baseline or started treatment during follow-up with a disease-modifying antirheumatic drug (DMARD) and 35% with a biological agent in addition to the DMARD. Both a history of secondary CNV (B=1.2, 95% CI 0.7-1.7, P=3.6×10-5) and high myopia (<-6 diopters) (B=0.6, 95% CI 0.1-1.1, P=0.02) independently increased the relapse rate of disease activity. Discussion/Conclusion A history of secondary CNV and high myopia were associated with an increased relapse rate of disease activity. Moreover, the results of this study emphasize the challenging character of treating patients with MFC/PIC.

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“White dot syndromes”, an inappropriate and outdated misnomer

Cited by 9 publications

References 18 publications

Radiolucent Lesions of the Jaws: An Attempted Demonstration of the Use of Co-Word Analysis to List Main Similar Pathologies

Radiolucent Lesions of the Jaws: An Attempted Demonstration of the Use of Co-Word Analysis to List Main Similar Pathologies

Diagnosis and Treatment of Primary Inflammatory Choriocapillaropathies (PICCPs): A Comprehensive Overview

Idiopathic Multifocal Choroiditis and Punctate Inner Choroidopathy – Evaluation of Risk Factors for Increased Relapse Rate: A 2-Year Prospective Observational Cohort Study

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