White blood cell differentials in dogs with congestive heart failure (CHF) in comparison to those in dogs without cardiac disease

Hamilton-Elliott, Julie; Ambrose, Eleanor; Christley, Robert M.; Dukes‐McEwan, Joanna

doi:10.1111/jsap.12809

Cited by 12 publications

(20 citation statements)

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“…Although the median values of WBC and white blood cell differential counts were within our reference ranges, signi cant differences in these parameters between our cardiac patients and healthy dogs indicate the development of the in ammatory process. The results are partially in accordance with other studies [8,10,13,15] and our previous study [12]. There have been a few studies investigating WBC and white blood cell differential counts in people [7,29,30].…”

Section: Discussionsupporting

confidence: 93%

“…Proin ammatory cytokines, especially TNF-α, IL-1, and IL-6, aggravate hemodynamic abnormalities, exert direct toxic effects on the heart and play a role in in ammation, tissue wasting, and weight loss [2]. Canine and human patients with heart failure have elevated levels of a number of in ammatory markers [1,8,10,12,13,14,15,20].…”

Section: Discussionmentioning

confidence: 99%

“…Markers of in ammation, such as C-reactive protein (CRP), cytokines, and their corresponding soluble receptors, white blood cell count (WBC) and markers of an activated immune system, have been reported to be elevated in human heart failure patients [4,5,6,7]. In canine patients with CHF, WBC, and concentrations of CRP and monocyte chemoattractant protein-1 concentrations have been found to be signi cantly higher in comparison to control dogs [8,9,10,11,12,13,14,15]. Besides, interleukin (IL)-2, IL-7, and IL-8 decreased with increasing severity indices of myxomatous mitral valve disease (MMVD) [14].…”

Section: Introductionmentioning

confidence: 99%

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Inflammation and its association with oxidative stress in dogs with heart failure

Svete

Verk

Čebulj‐Kadunc

et al. 2020

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Background Inflammation and oxidative stress can contribute to the development and progression of heart failure. This study aimed to investigate the association between inflammatory and oxidative stress markers in dogs with congestive heart failure (CHF). Associations between the disease severity marker N-terminal pro-B-type natriuretic peptide (NT-proBNP) and markers of inflammation and oxidative stress were also determined. Results Thirty-seven dogs with cardiovascular diseases (dilated cardiomyopathy (16 dogs), myxomatous mitral valve disease (21 dogs)) and ten healthy dogs were included in this prospective study. The patients were further divided into groups with (26) and without CHF (11). We found a significantly higher serum concentration of C-reactive protein (P = 0.012), white blood cell (P = 0.001), neutrophil (P = 0.001) and monocyte counts (P = 0.001) in patients with CHF compared to control dogs. The concentration of tumor necrosis factor-alpha (TNF-α) was significantly higher in patients with CHF compared to patients without CHF (P = 0.030). In patients with CHF, TNF-α correlated positively with malondialdehyde (P = 0.014, r = 0.474) and negatively with glutathione peroxidase (GPX) (P = 0.026, r = − 0.453), and interleukin-6 correlated negatively with GPX (P = 0.046, r = − 0.412). NT -proBNP correlated positively with malondialdehyde (P = 0.011, r = 0.493). In patients without CHF none of the inflammatory and oxidative stress markers correlated significantly. Furthermore, in the group of all cardiac patients, GPX activity significantly negatively correlated with NT-proBNP (P = 0.050, r = − 0.339) and several markers of inflammation, including TNF–α (P = 0.010, r = − 0.436), interleukin-6 (P = 0.026, r = − 0.382), white blood cell (P = 0.032, r = − 0.369), neutrophil (P = 0.027, r = − 0.379) and monocyte counts (P = 0.024, r = − 0.386). Conclusion Inflammatory and oxidative stress markers are linked in canine CHF patients, but not in patients without CHF. These results suggest complex cross communication between the two biological pathways in advanced stages of CHF.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inflammation and its association with oxidative stress in dogs with heart failure

Svete

Verk

Čebulj‐Kadunc

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Studies in people have already demonstrated that oxidative stress and chronic inflammation are linked in heart failure patients [1,2,16,20,25,26]. Canine and human patients with heart failure have elevated levels of a number of inflammatory markers [1,8,10,[12][13][14][15]20]. Proinflammatory cytokines, especially TNF-α, IL-1, and IL-6, aggravate hemodynamic abnormalities, exert direct toxic effects on the heart and play a role in inflammation, tissue wasting, and weight loss [2].…”

Section: Discussionmentioning

confidence: 99%

“…Markers of inflammation, such as C-reactive protein (CRP), cytokines, and their corresponding soluble receptors, white blood cell count (WBC) and markers of an activated immune system, have been reported to be elevated in human heart failure patients [4][5][6][7]. In canine patients with CHF, WBC, and concentrations of CRP and monocyte chemoattractant protein-1 have been found to be significantly higher in comparison to control dogs [8][9][10][11][12][13][14][15]. Besides, interleukin (IL)-2, IL-7, and IL-8 decreased with increasing severity indices of myxomatous mitral valve disease (MMVD) [14].…”

Section: Introductionmentioning

confidence: 99%

Inflammation and its association with oxidative stress in dogs with heart failure

et al. 2021

View full text Add to dashboard Cite

Background Inflammation and oxidative stress can contribute to the development and progression of heart failure. This study aimed to investigate the association between inflammatory and oxidative stress markers in dogs with congestive heart failure (CHF). Associations between the disease severity marker N-terminal pro-B-type natriuretic peptide (NT-proBNP) and markers of inflammation and oxidative stress were also determined. Results Thirty-seven dogs with cardiovascular diseases (dilated cardiomyopathy, DCM (16 dogs), myxomatous mitral valve disease, MMVD (21 dogs)) and ten healthy dogs were included in this prospective study. The patients were further divided into groups with (26) and without CHF (11). We found a significantly higher serum concentration of C-reactive protein (P = 0.012), white blood cell (P = 0.001), neutrophil (P = 0.001) and monocyte counts (P = 0.001) in patients with CHF compared to control dogs. The concentration of tumor necrosis factor-alpha (TNF-α) was significantly higher in patients with CHF compared to patients without CHF (P = 0.030). No significant difference was found in most of the measured parameters between MMVD and DCM patients, except for glutathione peroxidase (GPX) and NT-proBNP. In patients with CHF, TNF-α correlated positively with malondialdehyde (P = 0.014, r = 0.474) and negatively with GPX (P = 0.026, r = − 0.453), and interleukin-6 correlated negatively with GPX (P = 0.046, r = − 0.412). NT-proBNP correlated positively with malondialdehyde (P = 0.011, r = 0.493). In patients without CHF none of the inflammatory and oxidative stress markers correlated significantly. Furthermore, in the group of all cardiac patients, GPX activity significantly negatively correlated with NT-proBNP (P = 0.050, r = − 0.339) and several markers of inflammation, including TNF-α (P = 0.010, r = − 0.436), interleukin-6 (P = 0.026, r = − 0.382), white blood cell (P = 0.032, r = − 0.369), neutrophil (P = 0.027, r = − 0.379) and monocyte counts (P = 0.024, r = − 0.386). Conclusion Inflammatory and oxidative stress markers are linked in canine CHF patients, but not in patients without CHF. These results suggest complex cross communication between the two biological pathways in advanced stages of CHF.

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Selected hematological, biochemical, and echocardiographic variables as predictors of survival in canine patients with myxomatous mitral valve disease and congestive heart failure

Brložnik

Pečjak

Svete

et al. 2023

Journal of Veterinary Cardiology

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White blood cell differentials in dogs with congestive heart failure (CHF) in comparison to those in dogs without cardiac disease

Abstract: Dogs with congestive heart failure had a statistically significant increase in neutrophils, band neutrophils and monocytes in comparison with those without cardiac disease but the cell counts remained within normal reference intervals.

Cited by 12 publications

References 46 publications

Inflammation and its association with oxidative stress in dogs with heart failure

Inflammation and its association with oxidative stress in dogs with heart failure

Inflammation and its association with oxidative stress in dogs with heart failure

Selected hematological, biochemical, and echocardiographic variables as predictors of survival in canine patients with myxomatous mitral valve disease and congestive heart failure

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