White Blood Cell Count in Women: Relation to Inflammatory Biomarkers, Haematological Profiles, Visceral Adiposity, and Other Cardiovascular Risk Factors

Farhangi, Mahdieh Abbasalizard; Keshavarz, Seyed Ali; Eshraghian, M R; Ostadrahimi, Alireza; Saboor-Yaraghi, Ali-Akbar

doi:10.3329/jhpn.v31i1.14749

Cited by 119 publications

(106 citation statements)

References 32 publications

(36 reference statements)

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“…Additionally, increase in WBC count at the day of hospital discharge accompanied the increase in patients' BMI value. Our observations correlate with the epidemiological studies indicating the increase in WBC count in individuals with higher fat storage what probably is the result of obesity-driven inflammation [45,46].…”

Section: Discussionsupporting

confidence: 80%

Stability of peritoneal tissue evaluated by the means of DSC in obese patients undergoing laparoscopic cholecystectomy

Torres

Trębacz

Pietrzyk

et al. 2017

J Therm Anal Calorim

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Obesity is considered to be the leading metabolic disease in the world. The coincidence of postoperative complications is higher in obese individuals; thus, laparoscopic techniques due to their minimally invasive character became a standard in the surgical treatment of obesity. The proper function of peritoneal tissue is essential for the response to surgical trauma. Therefore, understanding the alterations of peritoneal tissue of obese individuals might explain the increased number of postoperative complications observed in obese patients. The study aimed to assess whether the stability of peritoneum is altered in obese patients and whether it corresponds to early postoperative complications in obese patients. Samples of parietal peritoneal tissue were collected at the beginning of the laparoscopic cholecystectomy from 80 patients. Differential scanning calorimetry was performed on samples defrosted at room temperature. Patients were divided into three groups according to the BMI value. For statistical analysis, ANOVA, Chi-square, Student's t test, and correlations with Pearson test were used. Significantly lower DH and higher T m were in patients in whom intraperitoneal adhesions were reported. Lower DH was reported in samples obtained from patients with temperature above 37°C in the first 24 h postoperatively. Enthalpy of thermal transition (DH) in peritoneum obtained from parous was significantly lower in comparison with the samples from nullipara. It can be concluded that DSC parameters correlated with parameters related to the early postoperative period. Occurrence of adhesions was reported more frequently in the group of obese and overweight individuals and correlated with lower change in enthalpy of collagen denaturation.

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Section: Discussionsupporting

confidence: 80%

Stability of peritoneal tissue evaluated by the means of DSC in obese patients undergoing laparoscopic cholecystectomy

Torres

Trębacz

Pietrzyk

et al. 2017

J Therm Anal Calorim

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“…A significant decrease in the percentage of monocytes was also observed in the overweight and obese groups when compared to the other BMI groups in the study which were similar to results recorded by other previous studies [30,31]. Leukocytosis has often been linked with atherosclerotic disease and has also been accepted as a risk factor for cardiovascular disease (CVD) [32].…”

Section: Discussionsupporting

confidence: 80%

Correlation between Body Mass Index and Hematological Indices in Young Adult Nigerians with Different Hemoglobin Genotypes

Ajayi¹,

Akinbo²,

Okafor³

2017

Am. J. Biomed. Sci.

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In view of the association of various haemoglobin electrophoretic patterns with different pathological conditions and obesity with its attendant risk factors for cardiac and pulmonary disorders, the present study evaluated the relationship between body mass index and haematological indices by randomly selecting young adult Nigerians with different haemoglobin electrophoretic patterns within the age group of 17-45 years and mean age of ±31 years old. 215 participants were enlisted for this study with their BMI and other anthropometric indices measured and grouped into different BMI categories as recommended by the World Health Organization. Haematological indices such as packed cell volume, total and differential white blood cell count, and platelets as well as haemoglobin (Hb) electrophoresis were assessed in relation to their anthropometric measurements using standard methods. We observed a significantly increased neutrophil and platelet counts in the subjects with BMI > 25 kg/m 2 . BMI was also observed to be positively correlated with the neutrophil, monocyte counts and MCV of haemoglobin AS and SS genotype groups in this study. This study showed a higher percentage of overweight and obesity among females, and haematological dyscrasias in mostly the HbSS subjects. Knowledge of the relationship between BMI and hematological indices of apparently healthy individuals within any population is therefore essential in healthcare planning, as a justification for early prognosis and genetic counselling policy strategically reducing the incidence of obesity, its attendant conditions and haemoglobinopathies in Nigeria.

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“…Therefore, there is growing concern that metabolic complications associated with HIV and antiretroviral drugs, place this population in a CVD high-risk category. HIV infection is associated with disturbed inflammatory response and immune dysfunction, leading to increased thrombosis and changes in lipid levels as well as cholesterol metabolism, which are also responsible for MS and CVD risk in the general population [16]. This long-term inflammatory state acts as a metabolic risk factor in the pathogenesis of HIV infection.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome in HIV infected adults in Poland

et al. 2018

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A b s t r a c tBackground: Metabolic syndrome (MS) is usually diagnosed based on the presence of abdominal obesity, elevated blood pressure (BP), elevated fasting plasma glucose, high serum triglycerides (TG), and low high-density lipoprotein (HDL) cholesterol levels. Whether HIV is associated with a higher prevalence of MS than in the general population remains unclear. Aim:The aim of the study was to determine the incidence of MS in the population of HIV-infected adults and its association with clinical, virological, and biochemical features. Methods:Two hundred and seventy HIV-infected Caucasian adult patients were enrolled in the study and evaluated based on clinical records in the years 2013-2015.Results: Metabolic syndrome was diagnosed in 60 of 270 (22%) patients, 47 (24%) males and 13 (17%) females, mostly (72%) aged above 40 years. The percentage of patients with diagnosed MS in specific age groups in comparison to the general Polish population for females aged < 40 years was 7% vs. 4%, and males in the same age -18% vs. 9%, for females aged 40-59 years -47% vs. 24.4%, and males -33% vs. 28.3%. Particular components of MS in the MS population were found as follows: body mass index > 30 kg/m 2 in 29%, waist circumference exceeding 94 cm in men and 80 cm in woman -87.5%, TG ≥ 150 mg/dL -82%, HDL cholesterol < 40/50 mg/dL (males/females) -42%, systolic/diastolic BP ≥ 130 mmHg/≥ 85 mmHg -83%, and fasting glucose > 100 mg/dL -42%. In stepwise multivariate logistic regression analysis, age (odds ratio [OR] 1.052, 95% confidence interval [CI] 1.018-1.088, p = 0.003) and nadir CD4 < 350 cells/mm 3 (OR 3.576, 95% CI 1.035-12.355, p = 0.04) were associated with MS. Patients with MS compared with those without this disorder had low, intermediate, high, and very high cardiovascular risk in 10% vs. 23%, 73% vs. 70%, 7% vs. 5%, and 10% vs. 2%, respectively (p = 0.006). Conclusions:Prevalence of MS in the HIV-infected population is higher than in the general Polish population. Age and low nadir CD4 were found to be associated with MS.

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White Blood Cell Count in Women: Relation to Inflammatory Biomarkers, Haematological Profiles, Visceral Adiposity, and Other Cardiovascular Risk Factors

Cited by 119 publications

References 32 publications

Stability of peritoneal tissue evaluated by the means of DSC in obese patients undergoing laparoscopic cholecystectomy

Stability of peritoneal tissue evaluated by the means of DSC in obese patients undergoing laparoscopic cholecystectomy

Correlation between Body Mass Index and Hematological Indices in Young Adult Nigerians with Different Hemoglobin Genotypes

Metabolic syndrome in HIV infected adults in Poland

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