White blood cell count in generalized aggressive periodontitis after non‐surgical therapy

Abstract

The results indicate that a therapeutical intervention may have a systemic effect on the blood count in GAP patients. This effect seems to differ between smokers and non-smokers.

Local and systemic immune responses in gingivitis and periodontitis

“…It therefore appears that in vivo, P. gingivalis can survive in blood and host tissues [47,48]. Our results showing higher WBC counts in venous blood of patients with periodontitis concur with the results of other authors [15,17,18,49].…”

“…The difference between smoking patients with periodontitis and smoking controls was not statistically significant. Christan et al [18] and Bokhari et al [51] found a significant reduction in WBC counts in venous blood after non-surgical therapy among non-smokers. Current knowledge suggests that smoking is associated with a less favorable response to periodontal therapy [50].…”

“…Most authors noticed that venous blood of patients with chronic periodontitis had elevated WBC counts [15][16][17], which after intensive non-surgical treatment decreased significantly for non-smokers [18,19], yet stayed the same for smoking patients [18].…”

Epidemiology: It’s Application in Periodontics

“…It has been stated that 90% of persons with refractory chronic periodontitis are smokers (Johnson & Slach, 2001). The healing following periodontal treatment is slower in smokers may be due to inhibition of growth and attachment of fibroblasts in the periodontal ligament and in slower reduction of white blood cells at diseased sites after therapy (Christan et al, 2002). Earlier studies showed no difference in prevalence of periodontal pathogens subgingivally (Preber et al, 1992), but more recent evidence suggests that smoking appears to promote a favorable habitat for pathogenic species in shallow pockets (Haffajee & Socransky, 2002).…”

An Investigation of Blood Hemogram and Estimation of Serum Iron and Protein Levels in Aggressive Periodontitis Patients: A Clinic Biochemical Study

“…7,8 Aggressive periodontitis comprises a group of rare, often severe, rapidly progressive forms of periodontitis often characterized by an early age of clinical manifestation and a distinctive tendency for cases to aggregate in families. 1,9 Aggressive periodontitis describes three diseases formerly classified as early onset periodontitis. production of prostaglandin E2 (PGE2) and IL-1β in response to bacterial endotoxins.…”