Relationships between work-related psychological and physical stress responses and counts
of white blood cells (WBCs), neutrophils, and lymphocytes were investigated in 101 daytime
workers. Counts of WBCs and neutrophils were positively associated with smoking and
inversely correlated with high density lipoprotein (HDL)-cholesterol levels. Additionally,
general fatigue score as measured by the profile of mood state was positively correlated
with WBC and neutrophil counts whereas lymphocyte counts was not significantly associated
with fatigue score. Multiple regression analysis showed that WBC count was significantly
related to general fatigue, age, and HDL-cholesterol levels. Neutrophil count was
significantly related to HDL-cholesterol levels and fatigue score. Among various
psychological stress response variables, general fatigue may be a key determinant of
low-grade inflammation as represented by increases of WBC and neutrophil counts.