Whisky tasting using a bimetallic nanoplasmonic tongue

Macías, Gerard; Sperling, Justin R.; Peveler, William J.; Burley, Glenn A.; Neale, Steven L.; Clark, Andrew

doi:10.1039/c9nr04583j

Cited by 29 publications

(33 citation statements)

References 50 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The unique physical properties of NPs have facilitated the design of selective and olfactory sensors, enabling differentiation of complex mixtures via pattern recognition. , The elegantly simple system of a NP modified with only a single surface ligand and three different adsorbed proteins can distinguish subtle differences between multiple cell types or cell phenotypes . Typically, antibodies are viewed as the canonical specific sensors because they are generated by an immune response specific to an antigen challenge .…”

Section: Discussionmentioning

confidence: 99%

Repurposing Old Antibodies for New Diseases by Exploiting Cross-Reactivity and Multicolored Nanoparticles

2020

View full text Add to dashboard Cite

We exploit the cross-reactivity of dengue (DENV) and zika (ZIKV) virus polyclonal antibodies for nonstructural protein 1 (NS1) to construct a selective sensor that can detect yellow fever virus (YFV) NS1 in a manner similar to chemical olfaction. DENV and ZIKV antibodies were screened for their ability to bind to DENV, ZIKV, and YFV NS1 by ELISA and in pairs in paper immunoassays. A strategic arrangement of antibodies immobilized on paper and conjugated to different colored gold NPs was used to distinguish the three biomarkers. Machine learning of test area RGB values showed that with two spots, readout accuracies of 100% and 87% were obtained for both pure NS1 and DENV/YFV mixtures, respectively. Additional image pre-processing allowed differentiation between all 4 DENV serotypes with 92% accuracy. The technique was extended to hack a commercial DENV test to detect YFV and ZIKV by augmentation with DENV and ZIKV polyclonal antibodies..

show abstract

Section: Discussionmentioning

confidence: 99%

Repurposing Old Antibodies for New Diseases by Exploiting Cross-Reactivity and Multicolored Nanoparticles

2020

View full text Add to dashboard Cite

show abstract

“…18 The conversion of the multifaceted interactions between the array and the analytes into optical responses, combined with statistical analysis of the resulting multidimensional optical response patterns, has enabled the accurate identification or classification of various bioanalytes ranging from isolated proteins [19][20][21][22][23] and cells 20,[24][25][26][27] to complex serum samples 21,[28][29][30] and fermented beverages. [31][32][33] Using the recognition of complex secretome compositions by chemical tongues, we have successfully detected stem-cell differentiation, 14 fibroblast senescence, 15 and drug responses in hepatoma cells 16 in a non-invasive manner.…”

Section: Introductionmentioning

confidence: 99%

A polymer-based chemical tongue for the non-invasive monitoring of osteogenic stem-cell differentiation by pattern recognition of serum-supplemented spent media

Tomita

Ishihara

Kurita

2022

Preprint

View full text Add to dashboard Cite

The development of non-invasive techniques to characterize cultured cells is invaluable not only to ensure the reproducibility of cell research, but also for quality assurance of industrial cell products for purposes such as regenerative medicine. Here, we present a polymer-based ‘chemical tongue’, i.e., a biosensing technique that mimics the human taste system, that is capable of non-invasively generating fluorescence response patterns that reflect the proteins secreted, and also partially consumed, by cultured cells, even from serum-supplemented media containing abundant interferants. Analysis of the spent media collected during cell culture using our chemical tongue, which consists of cationic polymers of different scaffolds appended with environmentally responsive dansyl fluorophores, led to the successful (i) identification of human-derived cell lines, (ii) monitoring of the differentiation process of stem cells, even at the stage when conventional staining was negative, and (iii) detection of cancer-cell contamination in stem cells. Since the characterization of cultured cells is usually performed via invasive methods that result in cell death, our chemical-tongue approach, which is of high practical utility, will offer a new means of addressing the growing demand for highly controlled cell production in the medical and environmental fields.

show abstract

“…For the analysis of ethanol and other components in alcoholic beverages, a variety of common analytical methods and sensitive reagents have been already developed. − The used methods include gas chromatography, mass spectrometry, UV–vis-IR spectrometry, colorimetric analysis, application of electrical transducers and different biosensors, solid-phase microextraction, use of green fluorescent proteins, and many others …”

Section: Introductionmentioning

confidence: 99%

“…10−18 The used methods include gas chromatography, 10 mass spectrometry, 11 UV−vis-IR spectrometry, 12 colorimetric analysis, 13 application of electrical transducers 14 and different biosensors, 15 solid-phase microextraction, 16 use of green fluorescent proteins, 17 and many others. 18 Analytical approaches based on fluorescent/luminescent techniques have to be specifically remarked. They are extremely sensitive; their sensitivity reached the absolute limit of single molecules.…”

Section: ■ Introductionmentioning

confidence: 99%

Photoluminescent Recognition of Strong Alcoholic Beverages with Carbon Nanoparticles

et al. 2021

View full text Add to dashboard Cite

A simple sensitive method for nonspecific recognition of armagnac, cognac, whiskey, and ethanol/water mixture was developed by using photoluminescence (PL) of carbon nanoparticles (NPs). The carbon NPs were synthesized from the mixture of urea and anhydrous citric acid, followed by few annealing processes to achieve the full effect by solvothermal carbonization. PL features of carbon NPs depend on the alcohol environments in which the NPs are dispersed. PL/PL excitation maps of the alcoholic beverages were mathematically treated, and a final principal component analysis diagram allows visualization of different clusters corresponding to each beverage. The optimal measurement conditions (concentration of NPs in colloidal solution and excitation wavelength) were defined to ensure a reliable recognition level.

show abstract

Whisky tasting using a bimetallic nanoplasmonic tongue

Abstract: In this paper, we present a bimetallic nanoplasmonic tongue capable of distinguishing between a variety of commercial whiskies.

Cited by 29 publications

References 50 publications

Repurposing Old Antibodies for New Diseases by Exploiting Cross-Reactivity and Multicolored Nanoparticles

Repurposing Old Antibodies for New Diseases by Exploiting Cross-Reactivity and Multicolored Nanoparticles

A polymer-based chemical tongue for the non-invasive monitoring of osteogenic stem-cell differentiation by pattern recognition of serum-supplemented spent media

Photoluminescent Recognition of Strong Alcoholic Beverages with Carbon Nanoparticles

Contact Info

Product

Resources

About