While I Still Remember: 30 Years of Alzheimer’s Disease Research

Shea, Thomas B.

doi:10.3233/jad-170724

Cited by 5 publications

(4 citation statements)

References 57 publications

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“…The increase in life expectancy observed over the last century has led to the emergence of a new set of pathologies that constitute new challenges to scientists and clinicians. Among these, Alzheimer disease (AD) 4 ( 1 ) has become a disorder with an increasing impact on society, because the number of diagnosed patients has more than doubled over the past 20 years and is expected to reach a prevalence worldwide of 75 million in 2030 and 131.5 million in 2050 ( https://www.alz.co.uk/research/world-report-2015 ). 5 Much of the increase is expected in developing countries.…”

Section: Introductionmentioning

confidence: 99%

Glycation affects fibril formation of Aβ peptides

Emendato

Milordini

Zacco

et al. 2018

Journal of Biological Chemistry

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Increasing evidence shows that β-amyloid (Aβ) peptides, which are associated with Alzheimer disease (AD), are heavily glycated in patients, suggesting a role of this irreversible nonenzymatic post-translational modification in pathology. Previous reports have shown that glycation increases the toxicity of the Aβ peptides, although little is known about the mechanism. Here, we used the natural metabolic by-product methylglyoxal as a glycating agent and exploited various spectroscopic methods and atomic force microscopy to study how glycation affects the structures of the Aβ40 and Aβ42 peptides, the aggregation pathway, and the morphologies of the resulting aggregates. We found that glycation significantly slows down but does not prevent β-conversion to mature fibers. We propose that the previously reported higher toxicity of the glycated Aβ peptides could be explained by a longer persistence in an oligomeric form, usually believed to be the toxic species.

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Section: Introductionmentioning

confidence: 99%

Glycation affects fibril formation of Aβ peptides

Emendato

Milordini

Zacco

et al. 2018

Journal of Biological Chemistry

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“…Despite this body of evidence linking life stress to dementia, few studies have examined the relationship between adverse events early in life and AD. Nevertheless, previous studies have reported a decline in cognition to begin years before clinical signs of AD (Shea and While, 2018 ). From this perspective, the risk factors must have occurred before this antecedent period, and thus, ACEs may be a potential factor influencing the onset of AD.…”

Section: Introductionmentioning

confidence: 93%

“…From this perspective, the risk factors must have occurred before this antecedent period, and thus, ACEs may be a potential factor influencing the onset of AD. In addition, previous evidence reports positive social factors such as social support, family history and social activities to be protective against AD (Bellis, 2014 ; Fink and Galea, 2015 ; Burke et al, 2017 ; Shea and While, 2018 ), which therefore suggests, in reverse conclusion, negative influences of ACEs.…”

Section: Introductionmentioning

confidence: 97%

The Relationship Between Adverse Childhood Experiences and Alzheimer's Disease: A Systematic Review

Corney

West

Quirk

et al. 2022

Front. Aging Neurosci.

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BackgroundAlzheimer's disease is a global health concern, and with no present cure, prevention is critical. Exposure to adverse childhood experiences may increase the risk of developing Alzheimer's disease. This systematic review was conducted to synthesize the evidence on the associations between adverse childhood experiences (<18 years) and the risk of Alzheimer's disease in adulthood.MethodsA search strategy was developed and conducted to identify articles investigating the associations between exposure to adverse childhood experiences and the onset of Alzheimer's disease by searching key databases (CINAHL, MEDLINE and PsycInfo). Two reviewers independently determined the eligibility of studies according to pre-determined criteria, and assessed the methodological quality using the US National Heart, Lung and Blood Institute 14-item checklist for observational cohort and cross-sectional studies, respectively. Due to limited studies, a descriptive synthesis was performed. The protocol for this review is published in BMJ Open and registered with PROSPERO (CRD42020191439).ResultsOur search yielded 781 articles, of which three (two separate analyses from the same cohort study and one cross-sectional study) met the predetermined eligibility criteria. The methodological quality assessment yielded an overall mean score of 78.9% (range 66.6 – 84.6%). All studies found adverse childhood experiences were associated with an increased risk of Alzheimer's disease. However, there was a limited number of available studies to inform the synthesis.ConclusionsAdverse childhood experiences appear to be associated with an increased risk of Alzheimer's disease, although, further research is needed.Registration and ProtocolThe protocol for this review is registered with PROSPERO (CRD42020191439) and published with BMJ Open (Corney et al., 2021).

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“…Nevertheless, previous studies have reported a decline in cognition to begin years before clinical signs of AD. 24 From this perspective, the risk factors must have occurred before this antecedent period, and thus, ACEs may be a potential factor influencing the onset of AD. In addition, previous evidence reports positive social factors to be protective against AD, [25][26][27][28] which therefore suggests, in reverse conclusion, negative influences of ACEs.…”

Section: Open Accessmentioning

confidence: 99%

Relationship between adverse childhood experiences and Alzheimer’s disease: a systematic review and meta-analysis protocol

et al. 2021

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IntroductionAlzheimer’s disease has a high prevalence and a substantial impact on society, as well as the individual. Findings from clinical studies to date, suggest that multiple factors are likely to contribute to the variability seen in the progression of Alzheimer’s disease. However, despite this accumulating evidence, current identified factors do not explain the full extent of disease onset. Thus, the role of additional factors needs to be explored further.One such factor is exposure to adverse childhood experiences. However, the degree of this association is unknown. This systematic review will examine the literature investigating the associations between adverse childhood experiences and the risk of Alzheimer’s disease.Methods and analysisArticles investigating associations between exposure to adverse childhood experiences and the risk of Alzheimer’s disease will be identified systematically by searching CINAHL, MEDLINE and PsycInfo using Ebscohost. No restrictions on date of publication will be applied. The search strategy will be built combining the main key elements of the Population, Exposure, Comparator, and Outcomes inclusion criteria. A meta-analysis is planned and statistical methods will be used to identify and control for heterogeneity, if possible. The development of this protocol was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols.Ethics and disseminationOnly published data will be used for this study, thus, ethical approval will not be required. Findings of the review will be published in a peer-reviewed scientific journal, and presented at national and international conferences.PROSPERO registration numberCRD42020191439.

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While I Still Remember: 30 Years of Alzheimer’s Disease Research

Cited by 5 publications

References 57 publications

Glycation affects fibril formation of Aβ peptides

Glycation affects fibril formation of Aβ peptides

The Relationship Between Adverse Childhood Experiences and Alzheimer's Disease: A Systematic Review

Relationship between adverse childhood experiences and Alzheimer’s disease: a systematic review and meta-analysis protocol

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