(1) Background: The COVID-19 pandemic forced educational institutions to radically change their teaching and learning methods. Many institutions found it a challenge when they opted to deliver classes online. Given the success of several EduTubers, this study aimed to identify their best practices. (2) Method: The research was qualitative in nature and descriptive in scope and analyzed three angles, namely the perspective of EduTubers, their videos, and the assessment of the audience. Moreover, the results demonstrated that the level of awareness of these practices varies among actors. (3) Results: The study identified 12 practices divided into four categories, namely (a) resource management, (b) communication strategies, (c) content management, and (d) pedagogical strategies. (4) Conclusions: Followers were aware of the most evident practices, such as tone of voice and length of explanation, whereas EduTubers clearly convey practices such as anchoring in prior knowledge and use of associations. However, when analyzing the videos of EduTubers, the study found that they used other practices with low levels of awareness, such as mental representations, balanced use of different resources, or management of topics in a logical and hierarchical order.