Which small blue round cell tumor of bone? how molecular techniques can be useful

Scrideli, Carlos Alberto; Queiróz, Rosane Gomes de Paula; Nogueira, Cleto Dantas; Engel, Edgard Eduard; Sankarankutty, Bianca Orteli Mori; Tone, Luíz Gonzaga

doi:10.1002/mpo.10165

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2008

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“…Although unlikely, molecular tests were performed to exclude a possible Ewing sarcoma or a B-cell lymphoma co-existing with the fungal osteomyelitis. Thus, RT-PCR analysis of the biopsied specimen for the detection of t(11;22)(q24;q12) and PCR assessment for gene rearrangements of heavy-chain immunoglobulin (IgH) and T-cell receptor (TCR) were carried out as previously reported [8]. The results were negative.…”

Section: Case Reportmentioning

confidence: 99%

Fungal infection by Paracoccidioides brasiliensis mimicking bone tumor

Valera

Mori

Engel

et al. 2008

Pediatric Blood & Cancer

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Paracoccidioides brasiliensis infection causes a systemic mycosis originally described in Latin America but with current reports of worldwide distribution. The clinical presentation of paracoccidiodomycosis as an isolated long-bone lesion in children is quite unusual. This article describes a 10-year-old male with a lytic femoral bone lesion caused by P. brasiliensis infection that was first suspected of being of neoplasic etiology. The text also emphasizes the importance of including endemic fungal infections in the differential diagnosis of bone lesions.

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Section: Case Reportmentioning

confidence: 99%