Which Portion in a Facet is Specifically Affected by Articular Cartilage Degeneration with Aging in the Human Lumbar Zygapophysial Joint?

Tanno, Iwao; Oguma, Hiroshi; Murakami, Gen; Sato, Shuichi; Yamashita, Toshihiko

doi:10.2535/ofaj.80.29

Cited by 11 publications

(11 citation statements)

References 9 publications

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“…This disparity was hypothesized as the reason for increased rates of pathology found in the talar dome compared to the tibial plafond. Within the human facet literature, there is conflict with regard to disposition of pathology, since some report a higher incidence of degeneration in the inferior facet surface [44] while others have concluded that the superior facet joint surface is more susceptible to pathology [45]. The biomechanical properties of human facet cartilage were not collected in this study due to the high incidences of pathology, and it remains unclear if disparities exist across the articulating surfaces of human facet joints.…”

Section: Discussionmentioning

confidence: 99%

Characterization of facet joint cartilage properties in the human and interspecies comparisons

et al. 2017

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This work provides the first comprehensive description of the properties of lumbar facet joint cartilage. Importantly, this work establishes that histological, biochemical, and mechanical properties are comparable between bipedal and quadrupedal animals, helping to guide future selection of appropriate animal models. This work also suggests that the human facet joint is highly susceptible to pathology. The mechanical properties of facet cartilage, found to be inferior to those of other synovial joints, provide a greater understanding of the joint's structure-function relationships as well as the potential etiology of facet joint pathology. Lastly, this work will serve as the foundation for the development of much-needed facet joint treatments, especially those based on tissue engineering approaches.

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Section: Discussionmentioning

confidence: 99%

Characterization of facet joint cartilage properties in the human and interspecies comparisons

et al. 2017

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“…Several investigations have also reported that osteophytes form along the posterior capsular attachment where the compressive and tensile stresses can become excessive in the hypermobile degenerative joint [1,296]. Furthermore, the posterior region of the facet joint is also found to be the most frequent location of cartilage defects [297], which may mean that nonphysiologic mechanical stresses develop at this location during extension when the intervertebral disc height decreases (because of disc degeneration or disc arthroplasty), making the posterior edge of the superior facet collide with the lamina of the inferior vertebra. Furthermore, an increase in the mechanical stress experienced by the bony articular pillar can also initiate or exacerbate degeneration by overstimulation of bone cells activity.…”

Section: Facet Joint Degeneration and The Bony Pillarsmentioning

confidence: 99%

Spinal Facet Joint Biomechanics and Mechanotransduction in Normal, Injury and Degenerative Conditions

Jaumard¹,

Welch²,

Winkelstein³

2011

J. Biomech. Eng.

261

225

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The facet joint is a crucial anatomic region of the spine owing to its biomechanical role in facilitating articulation of the vertebrae of the spinal column. It is a diarthrodial joint with opposing articular cartilage surfaces that provide a low friction environment and a ligamentous capsule that encloses the joint space. Together with the disc, the bilateral facet joints transfer loads and guide and constrain motions in the spine due to their geometry and mechanical function. Although a great deal of research has focused on defining the biomechanics of the spine and the form and function of the disc, the facet joint has only recently become the focus of experimental, computational and clinical studies. This mechanical behavior ensures the normal health and function of the spine during physiologic loading but can also lead to its dysfunction when the tissues of the facet joint are altered either by injury, degeneration or as a result of surgical modification of the spine. The anatomical, biomechanical and physiological characteristics of the facet joints in the cervical and lumbar spines have become the focus of increased attention recently with the advent of surgical procedures of the spine, such as disc repair and replacement, which may impact facet responses. Accordingly, this review summarizes the relevant anatomy and biomechanics of the facet joint and the individual tissues that comprise it. In order to better understand the physiological implications of tissue loading in all conditions, a review of mechanotransduction pathways in the cartilage, ligament and bone is also presented ranging from the tissue-level scale to cellular modifications. With this context, experimental studies are summarized as they relate to the most common modifications that alter the biomechanics and health of the spine-injury and degeneration. In addition, many computational and finite element models have been developed that enable more-detailed and specific investigations of the facet joint and its tissues than are provided by experimental approaches and also that expand their utility for the field of biomechanics. These are also reviewed to provide a more complete summary of the current knowledge of facet joint mechanics. Overall, the goal of this review is to present a comprehensive review of the breadth and depth of knowledge regarding the mechanical and adaptive responses of the facet joint and its tissues across a variety of relevant size scales.

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“…A degeneração da coluna é um evento muito comum. As alterações morfológicas foram descritas macroscopicamente [5][6][7] , histolologicamente 8 , e utilizando muitas técnicas de imagens diferentes tais como radiografia simples, discografia ressonância magnética ou tomografia computadorizada [9][10][11][12] . A literatura mostra diminuição da cartilagem articular, esclerose óssea subcondral, formação de osteófitos, hipertrofia e mais recentemente, degeneração facetá-ria 13 .…”

Section: Objetivos: Presentar Las Manifestaciones Clínicas Y Radiológunclassified

“…Havia 95 mulheres e 67 homens no total de pacientes. A tomografia computadorizada, radiografia simples (AP, lateral e dinâmicas) e resultados clínicos foram coletados no pré-operatório, 3,6,12,24,36,48,60, 72 e 84 meses após a cirurgia. O Índice de Incapacidade Relacionada ao Pescoço -Neck Disability Index (NDI) e a Escala Visual Analógica (EVA) foram utilizados para avaliar dor e resultados funcionais.…”

Section: Materiais E Métodosunclassified

Lições sobre a substituição total de disco cervical após sete anos de acompanhamento

Coutinho¹,

Oliveira²,

Marchi³

et al. 2012

Coluna/Columna

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RESUMOObjetivos: Apresentar a experiência clínica e radiológica da artroplastia cervical no tratamento da degeneração do disco intervertebral, mantendo o movimento e reduzindo o estresse e a degeneração dos segmentos adjacentes. Métodos: Foram estudadas as radiografias de 280 níveis em 161 pacientes (média de idade de 45,4 anos) tratados entre os níveis cervicais C3-4 e C7-T1. Setenta e um pacientes foram operados em um único nível, 67 pacientes em dois, 17 em três, e seis em quatro níveis. Os resultados radiológicos e clínicos foram coletados no pré-operatório, 1 semana, 1, 3 e 6 meses e anualmente. Questionários NDI/VAS foram utilizados para avaliar a dor e os resultados funcionais. Para a análise da degeneração facetária, foi utilizada uma escala de quatro graus com base em tomografias computadorizadas. Resultados: Os resultados clínicos melhoraram significativamente em todas as visitas pós-operatórias. A maioria dos pacientes evoluiu com grau I e II de degeneração facetária, e para esses casos não houve piora clínica, diferentemente de casos com grau III e IV. Entre os níveis estudados, 25 (8,93%) revelaram algum grau de HO: 14 apresentaram grau I (56%), 7 de grau II (28%), 3 com grau III (12%) e apenas um com grau IV (4%). Em 92% dos pacientes que desenvolveram HO havia presença de osteófitos incipientes. Ocorreu doença em nível adjacente em 5,7% dos pacientes. Conclusão: Os bons resultados clínicos também corroboram a superioridade do CTDR em comparação com a ACDF, já descritos na literatura.Descritores: Coluna vertebral; Artroplastia; Desenho de prótese; Disco intervertebral; Implante de prótese.

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Which Portion in a Facet is Specifically Affected by Articular Cartilage Degeneration with Aging in the Human Lumbar Zygapophysial Joint?

Cited by 11 publications

References 9 publications

Characterization of facet joint cartilage properties in the human and interspecies comparisons

Characterization of facet joint cartilage properties in the human and interspecies comparisons

Spinal Facet Joint Biomechanics and Mechanotransduction in Normal, Injury and Degenerative Conditions

Lições sobre a substituição total de disco cervical após sete anos de acompanhamento

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