Which Mechanism is Effective on the Hyperamylasaemia After Coronary Artery Bypass Surgery?

Algin, Halil Ibrahim; Parlar, Ali İhsan; Yıldız, İsmail; Altun, Zekiye; Islekel, Gul Huray; Uyar, İbrahim; Tulukoğlu, Engin; Karabay, Özalp

doi:10.1016/j.hlc.2016.09.006

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…This agrees with the very modest and transient increase in amylase. Of note, amylase levels have been found to be significantly elevated after coronary artery bypass surgery [15] and in variety of other conditions. Since the expression of trypsin-isoenzymes has been found not only in the pancreas, but also in many other tissues, including brain and biliary tract [6], disturbed function in these may also affect the levels of these markers.…”

Section: Discussionmentioning

confidence: 99%

Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest

Stewart

Koistinen

Lempiäinen

et al. 2020

Scandinavian Journal of Clinical and Laboratory Investigation

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The concentrations of several diagnostic markers have been found to increase dramatically in critically ill patients with a severe disturbance of normal physiological homeostasis, without indication of the diseases they are normally associated with. To prevent false diagnoses and inappropriate treatments of critically ill patients, it is important that the markers aiding the selection of second-line treatments are evaluated in such patients and not only in the healthy population and patients with diseases the markers are associated with. The levels of trypsinogen isoenzymes, the trypsin inhibitor serine peptidase inhibitor Kazal type 1 (SPINK1), hCG and hCGb, which are used as pancreatitis and cancer markers, were analyzed by immunoassays from serum samples of 17 adult patients who have undergone surgery of the ascending aorta during hypothermic circulatory arrest (HCA) with optional selective cerebral perfusion. Highly elevated levels of trypsinogen-1,-2 and-3, SPINK1 and hCGb were observed in patients after HCA. This was accompanied by increased concentrations of S100b and NSE. In conclusion, this study highlights the importance of critically evaluating the markers used for aiding selection of second line of treatments in critically ill patients.

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Section: Discussionmentioning

confidence: 99%

Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest

Stewart

Koistinen

Lempiäinen

et al. 2020

Scandinavian Journal of Clinical and Laboratory Investigation

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“…Достаточно часто развитие МАЕ связывают с проведением диагностических и лечебных оперативных вмешательств на органах брюшной полости, которые могут сопровождаться непосредственным или косвенным повреждением ПЖ. Вероятность появления изолированной МАЕ после выполнения оперативных вмешательств подтверждено результатами различных исследований и описанием отдельных клинических случаев [4]. Причем некоторые исследователи подчеркивают, что повышение уровня амилазы можно ожидать не только при абдоминальных вмешательствах, но и при выполнении кардиологических операций [4,45].…”

Section: патогенетические механизмыunclassified

“…Вероятность появления изолированной МАЕ после выполнения оперативных вмешательств подтверждено результатами различных исследований и описанием отдельных клинических случаев [4]. Причем некоторые исследователи подчеркивают, что повышение уровня амилазы можно ожидать не только при абдоминальных вмешательствах, но и при выполнении кардиологических операций [4,45]. Так, осуществляя аортокоронарное шунтирование с использованием аппарата экстракорпорального кровоснабжения, ученые зафиксировали возникновение бессимптомной доброкачественной МАЕ у 88% пациентов.…”

Section: патогенетические механизмыunclassified

Secrets, puzzles and mysteries of macroamylasemia

Губергріц

Byelyayeva

Лукашевич

et al. 2020

Bul. of the Club of Pancr.

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Physiological features of amylase synthesis and excretion are considered in the article, presence of other sources of amylase synthesis different from pancreas and salivary glands is emphasized. Definitions of hyperenzymemia and macroamylasemia (MAE) are given. MAE is a state characterized by presence of circulating complexes of normal serum amylase with protein or carbohydrates in blood. There are 3 types of MAE: first — classical (constant hyperamylasemia, decreased amylase level in urine, high blood concentration of macroamylase complexes); second — hyperamylasemia with slightly decreased amylase activity in urine, macroamylase/normal amylase ratio is less than in the first type; third — normal blood and urine amylase activity, low macroamylase/normal amylase ratio. Pathogenesis is explained by connection of blood amylase and acute phase protein in different inflammatory, infectious diseases, malabsorption. MAE clinical manifestations could be absent, sometimes abdominal pain is possible. Hyperamylasemia and reduced urine amylase activity are typical. MAE diagnostics means determination of macroamylase complexes in blood (chromatography, calculation of the clearance ratio of amylase and creatinine). The article presents clinical cases describing extra-pancreatic MAE in women with malignant ovarian lesions. The question of expediency of thorough diagnostic examination in asymptomatic MAE is raised, which may turn out to be a symptom of cancer. The lack of specific treatment for MAE is emphasized.

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Preoperative hyperamylasemia relates to renal dysfunction and hyperamylasemia in cardiac surgery: an observational study

Iwata,

Kawashima,

Nakajima

et al. 2024

Heart Vessels

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Which Mechanism is Effective on the Hyperamylasaemia After Coronary Artery Bypass Surgery?

Cited by 3 publications

References 20 publications

Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest

Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest

Secrets, puzzles and mysteries of macroamylasemia

Preoperative hyperamylasemia relates to renal dysfunction and hyperamylasemia in cardiac surgery: an observational study

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