Which Is Safer, Chinese Medicine or Western Medicine? Comparative Analysis Based on Chinese Spontaneous Reporting Database

Wei, Jianxiang; Zhiqiang, Liang; Feng, Guanzhong; Zhu, Yunxia

doi:10.1007/s11655-021-3340-7

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…Damnacanthus major, an evergreen shrub of the Rubiaceae family, is approximately 30-70 cm tall, and grows naturally in warm regions, such as Korea (southern), China (southern), Japan (southern), Thailand, and India [1,2]. Recently, the genetics [3,4], medicinal material quality control [5], and synthesis of new metabolites and drug prototypes [6] have been studied in the Rubiaceae family owing to the diversity of chemical constituents. Among various secondary metabolites produced by the Rubiaceae family, anthraquinones are biologically active with anti-inflammatory, antioxidant, anticancer, hemostatic, and antibacterial activities [7].…”

Section: Introductionmentioning

confidence: 99%

Metabolomics Reveals Rubiadin Accumulation and the Effects of Methyl Jasmonate Elicitation in Damnacanthus major Calli

Hyeon,

Jang,

Kim

et al. 2024

Plants

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Callus suspension techniques have been considered attractive for improving bioactive metabolite productivity; methyl jasmonate (MeJA) is a widely used elicitor for stimulating synthetic pathways. In this study, a multivariate analysis-based metabolomics approach was employed to investigate the primary and specialized metabolites in the leaves, unelicited calli, and 100 or 200 μM MeJA elicited calli of Damnacanthus major. Rubiadin, a powerful anthraquinone with various therapeutic properties, was only identified in D. major calli, accumulating in a MeJA elicitation concentration-dependent manner. Callus cultures also contained high levels of amino acids, sugars, and phenolic compounds, indicating energy metabolism and metabolic adaptation responses for proliferation and stabilization. Regarding MeJA application, elicited calli contained higher amounts of quinic acid, kaempferol, and glucose with lower amounts of sucrose and raffinose than those in the unelicited control, which were closely related to protective mechanisms against MeJA. Moreover, excessive elicitation increased the asparagine, fructose, and raffinose levels and decreased the glucose and sucrose levels, which was ascribed to increased activation of the aminoacyl-tRNA biosynthesis pathway and wider utilization of glucose than of fructose after sucrose degradation. These results will be useful for optimizing plant cell culture techniques to achieve high production rates for valuable specialized metabolites.

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Section: Introductionmentioning

confidence: 99%

Metabolomics Reveals Rubiadin Accumulation and the Effects of Methyl Jasmonate Elicitation in Damnacanthus major Calli

Hyeon,

Jang,

Kim

et al. 2024

Plants

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show abstract

“…In particular, as a potent antiviral nucleoside analog drug, there were concerns over the genetic safety and genotoxicity of molnupiravir ( 6 ). Traditional Chinese medicine (TCM) has often been perceived as safer and with better patient tolerability ( 7 ). Various TCMs have been approved by China's National Administration of TCM for the management of COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Initial observations of Jinhua Qinggan Granules, a Chinese medicine, in the mitigation of hospitalization and mortality in high-risk elderly with COVID-19 infection: A retrospective study in an old age home in Hong Kong

Lin¹,

Lau²,

Wan³

et al. 2022

Front. Med.

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Progress on Prevention and Treatment of Cerebral Small Vascular Disease Using Integrative Medicine

Zhang

Huang

Chen

et al. 2022

Chin. J. Integr. Med.

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Which Is Safer, Chinese Medicine or Western Medicine? Comparative Analysis Based on Chinese Spontaneous Reporting Database

Cited by 5 publications

References 22 publications

Metabolomics Reveals Rubiadin Accumulation and the Effects of Methyl Jasmonate Elicitation in Damnacanthus major Calli

Metabolomics Reveals Rubiadin Accumulation and the Effects of Methyl Jasmonate Elicitation in Damnacanthus major Calli

Initial observations of Jinhua Qinggan Granules, a Chinese medicine, in the mitigation of hospitalization and mortality in high-risk elderly with COVID-19 infection: A retrospective study in an old age home in Hong Kong

Progress on Prevention and Treatment of Cerebral Small Vascular Disease Using Integrative Medicine

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