Which factors can we control the transition from mild cognitive impairment to dementia?

The comorbidity conditions and polypharmacy in elderly patients with mental illness in a middle income country: a cross-sectional study⋆

“…Our findings show that, compared to cognitively healthy and depressive elderly people, dementia and MCI patients have a significantly higher number of comorbidities and greater comorbidity severity. This is indicated by a higher Charlson Comorbidity Index and by the greater proportion of severe CCI, as seen in previous studies ( Silay et al, 2017 ; Panpalli Ates and Yilmaz Can, 2020 ; Luck et al, 2010 ). However, it is important to highlight that Dementia and MCI groups were significantly older than the cognitively healthy and depressive disorder groups.…”

“…There is also a consensus in the literature that MCI is not necessarily a precursor to Alzheimer's disease, but there is a strong association between an MCI diagnosis and the increased risk for developing AD ( Sanford, 2017 ; Bennett et al, 2002 ). A recent paper found that vascular systemic diseases, among other clinical comorbidities, were the most prominent risk factor that influences the transitional stage from MCI to dementia and highlighted the importance of monitoring these physical conditions during MCI treatment ( Panpalli Ates and Yilmaz Can, 2020 ).…”

Brain Structural and Functional Changes in Cognitive Impairment Due to Alzheimer’s Disease

“…Around 10–15% of subjects with MCI could progress to dementia per year ( Petersen, 2000 ) and it has been estimated that overall more than 40% of subjects with MCI could develop dementia ( Panpalli Ates and Yilmaz Can, 2020 ). Thus, it is paramount to know why the other 60% do not progress similarly.…”