Which factors account for renal stone formation in cystic fibrosis?

Heiden, R von der; Balestra, Antonio; Mg, Bianchetti; Aebischer, C. Casaulta; Mullis, Primus-E.; Lippuner, Kurt; Jaeger, P

doi:10.5414/cnp59160

Cited by 11 publications

(2 citation statements)

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“…Calcium oxalate stones are the most common type of kidney stone found in PwCF. Urinary abnormalities that predispose to stone formation in PwCF include low urine output (i.e., dehydration), hyperoxaluria, hypocitraturia, and hypercalciuria [73,74]. PwCF are frequently prescribed antibiotics for pulmonary exacerbations; over time, frequent gut exposure to antibiotics can alter the GI flora.…”

Section: Nutritional Influences In Kidney Stone Disease In Cfmentioning

confidence: 99%

“…Antibiotics also decrease the breakdown of oxalate, causing hyperoxaluria. Reported mean age of onset for KSD in CF is early adulthood however stone recurrence is as high as 43% [69,73]. The CF community is seeing new emerging complexities in CF care in the era of HEMT and it is key that the CF care team has an increased awareness of new illnesses not commonly seen in PwCF in the past.…”

Section: Nutritional Influences In Kidney Stone Disease In Cfmentioning

confidence: 99%

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Evolving Nutritional Needs in Cystic Fibrosis

Frantzen

Barsky

LaVecchia

et al. 2023

Life

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The course of cystic fibrosis (CF) as a nutritional illness is diverging since the introduction of highly effective modulator therapy, leading to more heterogeneous phenotypes of the disease despite CF genetic mutations that portend worse prognosis. This may become more evident as we follow the pediatric CF population into adulthood as some highly effective modulator therapies (HEMT) are approved for those as young as 1 year old. This review will outline the current research and knowledge available in the evolving nutritional health of people with CF as it relates to the impact of HEMT on anthropometrics, body composition, and energy expenditure, exocrine and endocrine pancreatic insufficiencies (the latter resulting in CF-related diabetes), vitamin and mineral deficiencies, and nutritional health in CF as it relates to pregnancy and lung transplantation.

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Section: Nutritional Influences In Kidney Stone Disease In Cfmentioning

confidence: 99%

Section: Nutritional Influences In Kidney Stone Disease In Cfmentioning

confidence: 99%