Which exercise prescriptions improve quality of life and physical function in patients with cancer during and following treatment? A systematic review and meta-analysis of randomised controlled trials

Sweegers, Maike G.; Altenburg, Teatske M.; Chinapaw, Mai J. M.; Kalter, Joeri; Leeuw, Irma M. Verndonck-de; Courneya, Kerry S.; Newton, Robert U.; Aaronson, Neil K.; Jacobsen, Paul B.; Brug, Johannes; Buffart, Laurien M.

doi:10.1136/bjsports-2017-097891

Cited by 187 publications

(141 citation statements)

References 111 publications

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“…Other studies supported that treatment status (Chiu et al, 2015;Hilfiker et al, 2018;Sweegers et al, 2018), aerobic and strength exercises could influence cancer patients' sleep (Chiu et al, 2015;Hilfiker et al, 2018;Kovacevic, Mavros, Heisz, & Fiatarone Singh, 2018;Mercier et al, 2017).…”

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Meta‐analysis: Exercise intervention for sleep problems in cancer patients

et al. 2019

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Background Sleep problems cause physical and mental distress and may influence the survival of cancer patients. Objectives This study aimed to explore the efficacy of exercise intervention to improve sleep in cancer patients. Methods Published papers from 1980 to 2018 were searched. Results The major findings included (a) exercise intervention had small positive effects on enhancing total subjective sleep quality (TSSQ; g = 0.38, 95% CI = 0.21–0.54) and objective sleep onset latency (g = 0.21, 95% CI = 0.01–0.41). (b) The characteristics in subgroups in regarding the small to large effects of an exercise programme on sleep were identified. First, the groups of a home‐based exercise and a supervised exercise combined with a home‐based exercise had a medium effect on TSSQ than the usual group. Second, interventions with aerobic exercise, especially the 4‐ to 8‐week programmes and those with weekly volume of 80–149 min per week for cancer patients with ongoing or completed treatment also had a medium to large positive effect on TSSQ. Finally, patients with breast cancer and haematologic malignancies contributed a small effect in this meta‐analysis. Conclusions Maintaining regular aerobic exercises, even of different durations and weekly volumes, benefits patient sleep quality.

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confidence: 93%

“…Moreover, exercise intervention with supervised exercise or home-based exercise (Hageman, Fokkenrood, Gommans, Houten, & Teijink, 2018) and those with different exercise durations (Sweegers et al, 2018) have been reported positive effect on quality of life.…”

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Meta‐analysis: Exercise intervention for sleep problems in cancer patients

et al. 2019

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“…Regular daily physical activity is associated with a reduced risk of cancer development and a reduction in mortality after the diagnosis of cancer [1][2][3]. Additionally, physical activity and exercise interventions have significant beneficial effects on the level of fatigue and quality of life in patients with cancer [4][5][6]. Previous studies have also shown that the magnitude of these beneficial effects is greater in patients with worse baseline values of physical activity [6].…”

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confidence: 99%

Physical activity in patients with cancer: self-report versus accelerometer assessments

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Beaufort

Kampshoff

et al. 2019

Support Care Cancer

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Purpose The level of daily physical activity in patients with cancer is frequently assessed by questionnaires, such as the Physical Activity Scale for the Elderly (PASE). Objective assessments, with for example accelerometers, may be a good alternative. The aim of this study was to investigate the agreement between the PASE questionnaire and accelerometer-assessed physical activity in a large group of patients with different types of cancer. Methods Baseline accelerometer and PASE questionnaire data of 403 participants from the REACT (Resistance and Endurance Exercise After Chemotherapy, n = 227), the EXIST (Exercise Intervention After Stem-Cell Transplantation, n = 74), and NET-QUBIC (NEtherlands QUality of Life And Biomedical Cohort Studies In Cancer, n = 102) studies were available for the current analyses. Physical activity was assessed by the PASE questionnaire (total score) and accelerometers (total minutes per day > 100 counts). Linear mixed models regression analysis was used to assess the agreement between the PASE questionnaire and accelerometer-assessed physical activity. Results The mean (SD) PASE score was 95.9 (75.1) points and mean (SD) time in physical activity measured with the accelerometer was 256.6 (78.8) min per day. The agreement between the PASE score and the accelerometer data was significant, but poor (standardized regression coefficient (B) = 0.36, 95%CI = 0.27; 0.44, p < 0.01).

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“…Além disso, seria interessante analisar se o nível de condição física é um potencial mecanismo da relação AF-QV. Os programas de exercício acompanhados têm melhores resultados 50 , por isso os estudos de teor interventivo devem ser realizados em centros de EF, supervisionados por fisiologistas do exercício, de forma a reduzir o risco dos participantes não realizarem o que lhes foi solicitado e aumentar os níveis de segurança e eficácia e além disso devem ser aplicados diferentes planos de treino e diferentes tipos de treino, por exemplo, analisar os efeitos do treino com resistências ou o treino concorrente (aeróbio e de força), de forma a que se possa, aos poucos, ir compreendendo qual a frequência indicada, com que intensidade, durante quanto tempo, qual tipo, volume e periodização mais adequados. Seria interessante, no caso de sobreviventes sedentários, utilizar-se a abordagem da entrevista motivacional antes da prática de exercício, pois uma mensagem apropriada pode ter um papel importante ao nível da motivação para a prática de AF 51 e essa motivação pode ser essencial no que toca à adesão.…”

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Associação entre a atividade física e a qualidade de vida, em sobreviventes de cancro hematológico. Revisão Sistemática.

2019

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A atividade física tem um papel promissor na gestão dos efeitos colaterais dos cancros hematológicos, que são tumores dos tecidos hematopoiéticos ou linfoides. Nesse sentido, realizou-se uma revisão sistemática com o objetivo de analisar a associação entre a atividade física e a qualidade de vida em sobreviventes de cancro hematológico não sob tratamento. Foram utilizadas as bases de dados: PsycINFO, SportDiscus e Pubmed, com os critérios de inclusão no estudo: estudos randomizados controlados, estudos clínicos controlados e estudos observacionais. Encontraram-se 115 estudos possivelmente relevantes e foram incluídos na revisão 6 estudos, perfazendo um total de 1502 participantes (50.01% mulheres, idade média de 60.8 anos). A qualidade dos métodos foi considerada fraca. Apesar das diferentes especificidades metodológicas, verificou-se uma associação positiva entre a prática de atividade física e a qualidade de vida em vários domínios. Para conclusões mais consistentes, serão necessários mais estudos que colmatem as limitações observadas.

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Which exercise prescriptions improve quality of life and physical function in patients with cancer during and following treatment? A systematic review and meta-analysis of randomised controlled trials

Abstract: Exercise interventions, especially when supervised, have statistically significant and small clinical benefit on self-reported QoL and PF in patients with cancer. Unsupervised exercise intervention effects on PF were larger when prescribed at a higher weekly energy expenditure.

Cited by 187 publications

References 111 publications

Meta‐analysis: Exercise intervention for sleep problems in cancer patients

Meta‐analysis: Exercise intervention for sleep problems in cancer patients

Physical activity in patients with cancer: self-report versus accelerometer assessments

Associação entre a atividade física e a qualidade de vida, em sobreviventes de cancro hematológico. Revisão Sistemática.

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