Which Doppler Parameters Are Load Independent? A Study in Normal Volunteers After Blood Donation

Abalı, Gülcan; Tokgözoğlu, Lâle; Özcebe, Osman; Aytemir, Kudret; Nazli, Nasıh

doi:10.1016/j.echo.2005.06.012

Cited by 52 publications

(33 citation statements)

References 22 publications

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“…Mehmet Erturk et al, Severity of mitral stenosis and left ventricular function measurement of the ventricular contractility (end--systolic elastance) requires invasive quantification [22], and most of the contractile indexes (e.g., EF, MPI, and TDI-derived velocities or strain) are highly sensitive to loading conditions, it is thought that they might not reflect the intrinsic myocardial performance [17,23,24]. Isovolumic acceleration is a new tissue Doppler parameter for the assessment of systolic function of both left and the right ventricles [13,14].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of mitral stenosis severity on the left ventricular systolic function using isovolumic myocardial acceleration

Ertürk

Aksu²,

Çelik³

et al. 2014

Cardiol J

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Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of mitral stenosis severity on the left ventricular systolic function using isovolumic myocardial acceleration

Ertürk

Aksu²,

Çelik³

et al. 2014

Cardiol J

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“…Measurements included the systolic myocardial velocity and early and late diastolic myocardial velocities at the mitral annulus at the end of the respiration. The TDI technique is relatively insensitive to changes in loading condition (1) and is able to detect both systolic and diastolic dysfunction within 5 s after an acute reduction in LAD blood flow (12).…”

Section: Subjectsmentioning

confidence: 99%

Effect of cold air inhalation and isometric exercise on coronary blood flow and myocardial function in humans

Muller

Gao

Drew

et al. 2011

Journal of Applied Physiology

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Muller MD, Gao Z, Drew RC, Herr MD, Leuenberger UA, Sinoway LI. Effect of cold air inhalation and isometric exercise on coronary blood flow and myocardial function in humans. J Appl Physiol 111: 1694 -1702, 2011. First published September 22, 2011 doi:10.1152/japplphysiol.00909.2011.-The effects of cold air inhalation and isometric exercise on coronary blood flow are currently unknown, despite the fact that both cold air and acute exertion trigger angina in clinical populations. In this study, we used transthoracic Doppler echocardiography to measure coronary blood flow velocity (CBV; left anterior descending coronary artery) and myocardial function during cold air inhalation and handgrip exercise. Ten young healthy subjects underwent the following protocols: 5 min of inhaling cold air (cold air protocol), 5 min of inhaling thermoneutral air (sham protocol), 2 min of isometric handgrip at 30% of maximal voluntary contraction (grip protocol), and 5 min of isometric handgrip at 30% maximal voluntary contraction while breathing cold air (cold ϩ grip protocol). Heart rate, blood pressure, inspired air temperature, CBV, myocardial function (tissue Doppler imaging), O2 saturation, and pulmonary function were measured. The rate-pressure product (RPP) was used as an index of myocardial O2 demand, whereas CBV was used as an index of myocardial O2 supply. Compared with the sham protocol, the cold air protocol caused a significantly higher RPP, but there was a significant reduction in CBV. The cold ϩ grip protocol caused a significantly greater increase in RPP compared with the grip protocol (P ϭ 0.045), but the increase in CBV was significantly less (P ϭ 0.039). However, myocardial function was not impaired during the cold ϩ grip protocol relative to the grip protocol alone. Collectively, these data indicate that there is a supply-demand mismatch in the coronary vascular bed when cold ambient air is breathed during acute exertion but myocardial function is preserved, suggesting an adequate redistribution of blood flow. blood pressure; sympathetic nervous system; oxygen consumption; handgrip EXPOSURE TO COLD TEMPERATURES causes many physiological adjustments, most of which help prevent a fall in core body temperature. Specifically, peripheral vasoconstriction and shivering both raise blood pressure and effectively increase the work of the heart. These are known triggers of angina in clinical populations (33). Cardiac death is highest in the winter months, even in people who spend little time outdoors (45,54). While the effects of lowered skin temperature on cardiovascular function have been extensively studied (10,29,59,60), other mechanisms likely play a role in this process.Physical perturbation of the oropharynx and larynx elevates blood pressure in clinical settings (18,34), and laryngeal cold receptors have been identified in animals (38, 51). Previous studies (26,28,35,37) have shown that blood pressure, heart rate, and/or muscle sympathetic nerve activity are increased with cold air breathing in healthy humans. Acu...

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“…The E/Ea ratio is an appealing echocardiographic tool for non-invasive assessment of LVFP. This parameter is easily measured in a clinical echocardiographic laboratory [32] and is well validated with an E/Ea ratio of greater than 15 indicating increased LVFP [15], and recent data in normal subjects confirm the relative load independence of this measure [14].…”

Section: Discussionmentioning

confidence: 78%

“…TissueDoppler echocardiography is a relatively new technique with many features which suggest it may be another potential tool for the optimisation of HF treatment. The E/Ea ratio is a surrogate for left ventricular filling pressure (LVFP) [4][5][6][7][8][9][10][11][12][13][14][15][16] which has been shown to correlate well with BNP [17], and also to be an important marker of prognosis in HF patients [18,19]. Most of the data on the relationship between E/Ea and BNP relate to measurements at a single time point.…”

Section: Edical Treatment For Heart Failure (Hf) Is Well Establishementioning

confidence: 99%

Changes in Tissue-Doppler Echocardiographic Assessment of Left Ventricular Filling During NT-proBNP Guided Heart Failure Treatment Titration: A Pilot Study

Wasywich

Whalley

Walsh

et al. 2009

Heart, Lung and Circulation

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Which Doppler Parameters Are Load Independent? A Study in Normal Volunteers After Blood Donation

Cited by 52 publications

References 22 publications

Evaluation of the effect of mitral stenosis severity on the left ventricular systolic function using isovolumic myocardial acceleration

Evaluation of the effect of mitral stenosis severity on the left ventricular systolic function using isovolumic myocardial acceleration

Effect of cold air inhalation and isometric exercise on coronary blood flow and myocardial function in humans

Changes in Tissue-Doppler Echocardiographic Assessment of Left Ventricular Filling During NT-proBNP Guided Heart Failure Treatment Titration: A Pilot Study

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