Which aspects of executive dysfunction influence ability to manage diabetes in older adults?

Munshi, Medha N.; Hayes, Maggie; Iwata, Isao; Lee, Y.; Weinger, Katie

doi:10.1111/j.1464-5491.2012.03606.x

Cited by 22 publications

(31 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The association with education is in good agreement with other studies as increasing age and fewer years of education are known to affect the TMT results due to the types of tasks given (Munshi et al 2012;Voos et al 2011;Tombaugh 2004).…”

Section: Discussionsupporting

confidence: 87%

Influence of vascular risk factors on executive function among an age-homogeneous elderly cohort

Sédille-Mostafaie

Zehetmayer²,

Krampla

et al. 2015

J Neural Transm

View full text Add to dashboard Cite

The pathogenesis of executive dysfunction in geriatric depression remains uncertain although causal bidirectional relationships with depression have been discussed. Previous studies have described a potential link with 'vascular depression'. In this study, we investigate the influence of vascular risk factors and magnetic resonance imaging markers of structural brain ageing, such as increasing deep white matter hyperintensities (DWMH), on executive function in an age-homogeneous population-based study cohort. A total of 606 participants of identical age (75.8 years; standard deviation 0.45 years) took part in the baseline investigation of the Vienna Transdanube Ageing (VITA) study. Each participant underwent a full psychometric examination with standardised neuroimaging and clinical chemistry investigations. Participants were re-examined with the same protocol after exactly 30 and 60 months. Data refer to the individuals who completed the examination at baseline. In the ordinal logistic regression, fewer years of education (P < 0.0001), Trail Making Test-A (P < 0.0001), high homocysteine (P = 0.001), and depression (P < 0.0001) were significantly associated with Trail Making Test-B (TMT-B) values. A significant influence of other vascular risk factors, such as lipids, diabetes, and smoking, on executive dysfunction was not observed. A comparison of both lacunes and DWMH with respect to the TMT-B results showed no significant correlation. Our data do not support the notion that vascular pathogenesis might underlie executive dysfunction.

show abstract

Section: Discussionsupporting

confidence: 87%

Influence of vascular risk factors on executive function among an age-homogeneous elderly cohort

Sédille-Mostafaie

Zehetmayer²,

Krampla

et al. 2015

J Neural Transm

View full text Add to dashboard Cite

show abstract

“…A recent meta-analysis identified reliable decrements associated with T2DM that were relatively uniform across EF measurement approaches and conceptual subtypes of EF (8) Impaired EF among the T2DM population is potentially problematic because of the role of EF integrity in the consistent implementation, assessment and adaptation behaviours necessary in diabetes self-care (20)(21)(22)(23)(24). For example, EF has been implicated in the ability to perform healthy dietary behaviours, consistently follow physical activity recommendations, adhere to medication regimens and maintain weight loss (21,(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36), all of which are required for effective management of T2DM (37). For this reason, effective disease management may rely partially on intact executive control capacities.…”

Section: Resultsmentioning

confidence: 99%

Cognitive effects of a 30-min aerobic exercise bout on adults with overweight/obesity and type 2 diabetes

Vincent

Hall

2017

Obesity Science & Practice

View full text Add to dashboard Cite

SummaryBackgroundSeveral studies document reliable brain health benefits of acute exercise bouts. However, no prior studies have explored such effects among those living with co‐morbid overweight/obesity and type 2 diabetes (T2DM), both of which are conditions associated with cognitive performance decrements.PurposeTo examine the impact of a 30‐min bout of moderate‐intensity aerobic exercise on executive function among adults with overweight/obesity and T2DM, employing a widely used experimental paradigm.MethodsThirty adults with overweight/obesity and T2DM were randomly assigned to moderate (30% maximal heart rate reserve) and minimal (r.p.m. 30–50; work load 5) intensity aerobic exercise. Pre‐exercise to post‐exercise changes in Stroop interference and Go/No‐Go scores were compared across conditions.ResultsPrimary analyses revealed no overall effect of exercise condition on changes in Stroop or Go/No‐Go performance. Post‐hoc moderation analyses indicated that Stroop interference scores were reduced, following moderate exercise among female participants and among those who were more physically active.ConclusionThe current study revealed no reliable benefit of acute aerobic exercise for overweight and obese individuals living with T2DM overall. There may be limited benefits for women and more and active subgroups, but the precise nature of such benefits remains unclear.

show abstract

“…However, some executive functions could be important for perform complex tasks required for self care, such as blood glucose monitoring and, dietary modification and regular physical activity. One study revealed that in older adults, executive dysfunction detected by objective tests is associated with poor glycaemic control [38]. Impairments in executive function are associated with poor adherence to medication, low independence or instrumental activities of daily living, and low autonomy and inability to make decisions.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with poor glycaemic control in type 2 diabetic elderly patients with mild cognitive impairment

Górska-Ciebiada¹,

Ciebiada²

2019

J Pre Clin Clin Res.

View full text Add to dashboard Cite

Gorska-Ciebiada M, Ciebiada M. Factors associated with poor glycaemic control in type 2 diabetic elderly patients with mild cognitive impairment.Abstract Introduction and objective. Recently, data has indicated a higher incidence of mild cognitive impairment (MCI) in patients with diabetes. Old age is a risk factor for cognitive deterioration and dementia. The aim of the study was to find the factors associated with poor glycaemic control in type 2 diabetic elderly patients with MCI. Materials and method. A cross-sectional study was conducted on 87 diabetic patients with MCI in an outpatient clinic. All subjects were screened for MCI using the Montreal Cognitive Assessment (MoCA). Detailed medical history and collection of blood test samples were performed. Results. 83.9% of participants had poor glycaemic control. A positive correlation was found between HbA1c level and number of visit to a doctor per year, number of co-morbidities, duration of T2DM, triglycerides and fasting glucose level; and a negative correlation between HbA1c level and years of education, HDL cholesterol level and MoCA score. The univariate logistic regression models revealed factors which are associated with poor glycemic control are: less years of education, higher no of visit to doctor per year, increased number of co-morbidities, presence of CVD, retinopathy, higher levels of triglycerides and fasting glucose, lower level of HDL cholesterol, lower MoCA score. Multivariable model revealed that higher plasma levels of fasting glucose and triglycerides are significant predictors. Conclusions. There is a high prevalence of poor glycemic control patients among elderly diabetics with MCI. Higher plasma levels of fasting glucose and triglycerides seems to be the most important predictors of poor glycemic control, however father larger studies are needed to elucidate these relationships.

show abstract

Which aspects of executive dysfunction influence ability to manage diabetes in older adults?

Cited by 22 publications

References 27 publications

Influence of vascular risk factors on executive function among an age-homogeneous elderly cohort

Influence of vascular risk factors on executive function among an age-homogeneous elderly cohort

Cognitive effects of a 30-min aerobic exercise bout on adults with overweight/obesity and type 2 diabetes

Factors associated with poor glycaemic control in type 2 diabetic elderly patients with mild cognitive impairment

Contact Info

Product

Resources

About