Whey Protein Supplementation Enhances Body Fat and Weight Loss in Women Long After Bariatric Surgery: a Randomized Controlled Trial

Gomes, Daniela Lopes; Moehlecke, Milene; Silva, Fernanda Bassan Lopes da; Dutra, Eliane Said; Schaan, Beatriz D’Agord; Carvalho, Kênia Mara Baiocchi de

doi:10.1007/s11695-016-2308-8

Cited by 43 publications

(24 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, prior studies demonstrated that whey protein supplementation has fat mass, reducing effects in overweight and obese humans [48,49]. Similarly, high fat-fed mice consuming whey proteins were protected from early life weight gain and displayed improved glucose tolerance [50], suggesting that whey protein consumption has an anti-adipogenic effect.…”

Section: Discussionmentioning

confidence: 99%

Whey Peptides Stimulate Differentiation and Lipid Metabolism in Adipocytes and Ameliorate Lipotoxicity-Induced Insulin Resistance in Muscle Cells

et al. 2020

View full text Add to dashboard Cite

Deregulation of lipid metabolism and insulin function in muscle and adipose tissue are hallmarks of systemic insulin resistance, which can progress to type 2 diabetes. While previous studies suggested that milk proteins influence systemic glucose homeostasis and insulin function, it remains unclear whether bioactive peptides generated from whey alter lipid metabolism and its accumulation in muscle and adipose tissue. Therefore, we incubated murine 3T3-L1 preadipocytes and C2C12 myotubes with a whey peptide mixture produced through pepsin-pancreatin digestion, mimicking peptides generated in the gut from whey protein hydrolysis, and examined its effect on indicators of lipid metabolism and insulin sensitivity. Whey peptides, particularly those derived from bovine serum albumin (BSA), promoted 3T3-L1 adipocyte differentiation and triacylglycerol (TG) accumulation in accordance with peroxisome proliferator-activated receptor γ (PPARγ) upregulation. Whey/BSA peptides also increased lipolysis and mitochondrial fat oxidation in adipocytes, which was associated with the upregulation of peroxisome proliferator-activated receptor δ (PPARδ). In C2C12 myotubes, whey but not BSA peptides ameliorated palmitate-induced insulin resistance, which was associated with reduced inflammation and diacylglycerol accumulation, and increased sequestration of fatty acids in the TG pool. Taken together, our study suggests that whey peptides generated via pepsin-pancreatin digestion profoundly alter lipid metabolism and accumulation in adipocytes and skeletal myotubes.

show abstract

Section: Discussionmentioning

confidence: 99%

Whey Peptides Stimulate Differentiation and Lipid Metabolism in Adipocytes and Ameliorate Lipotoxicity-Induced Insulin Resistance in Muscle Cells

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Thus far, a total of 45 trials have been performed to investigate the effect of acute and chronic milk protein supplementation on various parameters related to glucose control, including glucose, insulin, GLP‐1, and GIP, in healthy subjects, and in patients with T2DM, metabolic syndrome, or prediabetes . Ideally, a meta‐analysis should be performed to quantify the effects of milk proteins on these parameters; however, the heterogeneous nature of the trials does not permit us to perform such an analysis.…”

Section: Summarizing the Evidence Of The Effects Of Milk Proteins On mentioning

confidence: 99%

“…Most short‐term trials found that the acute ingestion of milk proteins, particularly whey, stimulates incretin hormone secretion, increases the insulin response, and reduces postprandial glucose levels in healthy subjects and patients with T2DM. To the best of our knowledge, only four long‐term trials have investigated the glycemic and insulinemic effects of chronic milk protein supplementation. Of these long‐term trials, only one enrolled patients with T2DM .…”

Section: Summarizing the Evidence Of The Effects Of Milk Proteins On mentioning

confidence: 99%

“…Of these long‐term trials, only one enrolled patients with T2DM . The findings from long‐term trials remain conflicting, as some studies showed an improvement in glucose control with whey supplementation, whereas others showed null results …”

Section: Summarizing the Evidence Of The Effects Of Milk Proteins On mentioning

confidence: 99%

“…In this regard, milk proteins (whey and casein) and their derived peptides have been some of the most extensively studied dairy nutrients in humans. To date, a large number of trials have investigated the effect of milk protein supplementation on glucose control in healthy subjects and in patients with T2DM . In general, the results from these trials showed that milk proteins may have functional properties for stimulating postprandial insulin, resulting in lower postprandial glucose levels.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Milk in the prevention and management of type 2 diabetes: The potential role of milk proteins

Hidayat

Shi

2019

Diabetes Metabolism Res

View full text Add to dashboard Cite

Globally, diabetes mellitus is not only considered a leading cause of mortality and morbidities but has also created a substantial economic burden. There is growing evidence that foods and their components can be implemented in the prevention and management of type 2 diabetes mellitus (T2DM). Increased dairy consumption has been linked to a lower risk of T2DM. The protective role of dairy foods in the development of T2DM is thought to be largely attributable to dairy nutrients, one of them being dairy protein. There is considerable evidence that milk proteins increase the postprandial insulin response and lower the postprandial blood glucose response in both healthy subjects and patients with T2DM. The exact mechanisms by which milk proteins lower postprandial glucose levels are yet to established; however, the amino acids and bioactive peptides derived from milk proteins are thought to modify a physiological milieu, which includes delayed gastric emptying and the enhancement of incretin and insulin responses, consequently leading to lower postprandial glucose levels. The present review will focus on providing a clear presentation of the potential implementation of milk proteins as a dietary supplement in the prevention and management of T2DM by summarizing the relevant supporting evidence for this particular topic.

show abstract

Suboptimal Weight Loss After Bariatric Surgery: Mechanisms and Treatment Algorithms

Mok

Batterham

2022

Obesity, Bariatric and Metabolic Surgery

View full text Add to dashboard Cite

Whey Protein Supplementation Enhances Body Fat and Weight Loss in Women Long After Bariatric Surgery: a Randomized Controlled Trial

Abstract: Whey protein supplementation promoted body weight and FM loss in women with long-term weight regain following RYGB.

Cited by 43 publications

References 29 publications

Whey Peptides Stimulate Differentiation and Lipid Metabolism in Adipocytes and Ameliorate Lipotoxicity-Induced Insulin Resistance in Muscle Cells

Whey Peptides Stimulate Differentiation and Lipid Metabolism in Adipocytes and Ameliorate Lipotoxicity-Induced Insulin Resistance in Muscle Cells

Milk in the prevention and management of type 2 diabetes: The potential role of milk proteins

Suboptimal Weight Loss After Bariatric Surgery: Mechanisms and Treatment Algorithms

Contact Info

Product

Resources

About