Whey protein-containing product reduces muscle damage induced by running in male adults

Baba, Seigo; Ebihara, Shukuko; Sakano, Katsuhisa; Natsume, Mitsutaka

doi:10.1007/s11332-014-0178-9

Cited by 2 publications

(9 citation statements)

References 22 publications

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“…Of the 34 included studies, 19 used a parallel group design [ 48 , 49 , 51 , 52 , 53 , 54 , 55 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ], 3 had three treatment arms [ 52 , 54 , 63 ], and 2 had four treatment arms [ 68 , 74 ]. The remaining 15 studies employed a crossover design [ 8 , 30 , 50 , 56 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 ], three of which had three treatment arms [ 50 , 80 , 81 ].…”

Section: Resultsmentioning

confidence: 99%

“…Nineteen studies recruited healthy athletes or highly trained professionals [ 8 , 30 , 48 , 50 , 55 , 56 , 65 , 70 , 71 , 74 , 76 , 77 , 78 , 79 , 80 , 82 , 83 , 84 , 85 ], and nine studies were conducted on recreationally active participants or participants that habitually performed resistance exercise training 1 to 2 days a week [ 51 , 53 , 54 , 66 , 67 , 69 , 72 , 73 , 81 ]. Six studies were on untrained participants [ 49 , 52 , 63 , 64 , 68 , 75 ].…”

Section: Resultsmentioning

confidence: 99%

“…Whey protein. Of the twelve studies with whey protein supplementation, only two demonstrated favorable anti-inflammatory or antioxidant effects [ 30 , 50 ], with the remaining ten reporting no effects [ 51 , 54 , 63 , 66 , 75 , 76 , 78 , 80 , 81 , 82 ].…”

Section: Resultsmentioning

confidence: 99%

“…Whey protein isolate. Seven studies examined the effect of whey protein isolate on markers of exercise-induced inflammation and oxidative stress; none of them reported changes with the intervention [ 54 , 63 , 66 , 75 , 76 , 80 , 82 ]. In Baba et al [ 75 ], whey protein isolate (22.8 g) before, during, and after exercise did not attenuate IL-6 4 h post-exercise ( p = 0.055).…”

Section: Resultsmentioning

confidence: 99%

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The Effects of Dietary Protein Supplementation on Exercise-Induced Inflammation and Oxidative Stress: A Systematic Review of Human Trials

et al. 2021

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This systematic review examined the effects of whole protein and commonly consumed amino acid supplements on markers of exercise-induced inflammation and oxidative stress and was reported according to the PRISMA guidelines. MEDLINE and SPORTDiscus were searched from inception until June 2021. The inclusion criteria were randomized clinical trials in humans, healthy adult participants (≥18 years), dietary protein/amino acid interventions, and measurements of oxidative stress/the redox status or inflammation post-exercise. The Cochrane Collaboration risk of bias 2 tool was used to critically appraise the studies. Data extracted from thirty-four studies were included in the systematic review (totaling 757 participants with only 10 females; age range 19–40 years). The included trials examined five types of whole protein and seven different amino acids supplements; most studies (n = 20) failed to identify statistically significant effects on markers of inflammation or oxidative stress after exercise; some (n = 14) showed either anti-inflammatory or antioxidant effects on some, but not all, markers. In conclusion, we found weak and inconsistent evidence that dietary protein/amino acid interventions can modify exercise-induced changes in oxidative stress and inflammation. However, given that these were not the primary outcomes in many of the included studies and many had design limitations, further research is warranted (Open Science Framework registration number: 10.17605/OSF.IO/AGUR2).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The Effects of Dietary Protein Supplementation on Exercise-Induced Inflammation and Oxidative Stress: A Systematic Review of Human Trials

et al. 2021

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“…Schroer et al [17] showed that IL-6 was lower with whey protein, compared to placebo during a 60min bout of intense cycling. Another study investigating whey protein's effects on muscle damage showed that while markers of muscle damage were decreased with multiple supplementations throughout the 60 minute exercise bout, it was not able to significantly attenuate the increase of IL-6 [37]. It is possible that longer exercise times and the timing of supplementation result in different interactions between whey protein and IL-6.…”

Section: Plasma Il-6 and Dpp-ivmentioning

confidence: 99%

Post-exercise Glucose Response Following Whey Protein Ingestion in Healthy Young People: A Randomized Pilot Study

Kluess¹,

Neidert²

2018

TODIAJ

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Background: Whey protein may have an effect directly on the muscle to affect exercise glucose response. Objective: The study aimed to measure post-exercise glucose recovery with supplementation and the role of DPP-IV and IL-6. Methods: Twenty-four participants were randomly assigned to one of three supplementation conditions (CTL: water, WPI: 31g whey protein isolate, and CHO: 32g fructose beverage; WPI and CHO beverages were isocaloric). During the Baseline Visit, participants performed an Oral Glucose Tolerance Test (OGTT) with no exercise or supplementation. On their second and third visits, participants consumed their assigned beverage then completed a maximal treadmill protocol until volitional fatigue. An OGTT was completed on the second visit, and blood samples were collected via venipuncture on the third visit for IL-6, Insulin and DPP-IV. Results: Glucose delta peak was attenuated in WPI+exercise by -45±25% and CHO+exercise by -49±21%, compared to baseline (p<0.05). Glucose area under the curve was only attenuated with WPI+exercise (5,993±1,013mg/dl*min), compared to baseline (10,604±4,589mg/dl*min; p<0.05). Insulin was elevated in the WPI+exercise (111±57pmol/L) and CHO+exercise (119±70pmol/L), compared to rest (WPI: 61±40pmol/L; CHO: 78±56pmol/L; p<0.05). IL-6 and DPP-IV activated T-cells (CD26+) were not different among groups. However, plasma DPP-IV was higher in WPI (8±6U/L) compared to CTL (0.7±2U/L) and CHO (0.6±4U/L; p<0.05). Conclusion: We found that a single dose of whey protein given prior to exercise results in elevated DPP-IV activity in the plasma and improved glucose response. Together these data suggest that whey protein as a supplement to exercise may be beneficial for humans trying to manage their blood sugar.

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Whey protein-containing product reduces muscle damage induced by running in male adults

Cited by 2 publications

References 22 publications

The Effects of Dietary Protein Supplementation on Exercise-Induced Inflammation and Oxidative Stress: A Systematic Review of Human Trials

The Effects of Dietary Protein Supplementation on Exercise-Induced Inflammation and Oxidative Stress: A Systematic Review of Human Trials

Post-exercise Glucose Response Following Whey Protein Ingestion in Healthy Young People: A Randomized Pilot Study

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