Whey peptide ingestion suppresses body fat accumulation in senescence-accelerated mouse prone 6 (SAMP6)

Abstract

These data suggest that a normal (or moderate excess) dietary density of whey peptide attenuates body fat accumulation via upregulation of fatty acid oxidation in skeletal muscle in aging mice.

Whey Peptides Stimulate Differentiation and Lipid Metabolism in Adipocytes and Ameliorate Lipotoxicity-Induced Insulin Resistance in Muscle Cells

“…Soybean-derived peptides improved glucose transport and insulin signaling in high fat diet-fed mice and in insulin-resistant C2C12 myotubes via upregulation of insulin receptor and insulin receptor substrate 1 and activation of AMPK [51,52]. Whey peptides were also previously shown to stimulate glucose uptake, glycogen synthesis, and AMPK activity [24,27,29]. Our current work complements these studies by showing that whey peptide treatment ameliorates lipotoxicity-induced insulin-resistance in C2C12 myotubes.…”

“…Insulin sensitization of these tissues, therefore, can potentially reduce and prevent systemic insulin resistance and its complications. Recent studies have demonstrated that hydrolysis of milk proteins, including whey proteins, generates bioactive peptides that can affect glucose homeostasis [18,24,29]. However, it remained unclear whether and how whey peptide exposure affects lipid metabolism and insulin sensitivity in adipose tissue and skeletal muscle.…”

“…Whey protein mainly consists of β-lactoglobulin (50%), α-lactalbumin (20%), and serum albumin (10%) [23], all of which can serve as sources of bioactive peptides. Whey peptide supplementation was shown to reduce fat mass in senescent mice [24]. Hydrolysate from bovine α-lactalbumin ameliorated high fat diet-induced body weight gain and improved systemic glucose homeostasis in mice [25].…”

“…A β-lactoglobulin-derived peptide reduced hepatic TG and cholesterol accumulation in zebrafish [26]. In skeletal muscle, the consumption of whey protein or peptides resulted in increased glycogen levels in mice and rats and adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in mice [24,27,28]. Exposure to whey-derived dipeptides also stimulated non-insulin dependent glucose uptake in L6 myotubes and isolated rat muscle [29].…”

Functional effects of milk bioactive peptides on skeletal muscle of rats

“…Moreover, it has been reported that the consumption of whey protein hydrolysate (WPH) is associated with other health effects, such as an increase in the translocation of GLUT-4 (Morato et al, 2013), an improvement in satiety signals (Luhovyy, Akhavan, & Anderson, 2007) and an increase in glycogen content (Morifuji, Sakai, Sanbongi, & Sugiura, 2005). Several molecular effects caused by the consumption of WPH have been connected to the presence of bioactive peptides (Ichinoseki-Sekine, Kakigi, Miura, & Naito, 2014;Luhovyy et al, 2007), including the possible role of branched-chain amino acids (BCAAs) and peptides in the HSP response (De Moura et al, 2014). The presence of BCAA-containing peptides in WPH has been reported (Morifuji, Koga, Kawanaka, & Higuchi, 2009).…”