Whether western normative laboratory values used for clinical diagnosis are applicable to Indian population? An overview on reference interval

Malati, T.

doi:10.1007/s12291-009-0022-1

Cited by 12 publications

(12 citation statements)

References 47 publications

(37 reference statements)

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“…Such changes are known to influence hormone levels. Further, international guidelines have recommended the establishment of reference intervals for every country and the lack of such studies in India has been recently reported (12). In the present study, the various reference hormone values measured using EIA/ELISA were within the physiological range for each ethnic group in subjects between 20 to 50 years of age.…”

Section: Discussionsupporting

confidence: 58%

Evaluation of plasma hormone concentrations using Enzyme-Immunoassay/Enzyme-linked Immunosorbent assay in healthy Indian men: Effect of ethnicity

Sachidhanandam

Singh

Salhan

et al. 2010

Indian J Clin Biochem

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Section: Discussionsupporting

confidence: 58%

Evaluation of plasma hormone concentrations using Enzyme-Immunoassay/Enzyme-linked Immunosorbent assay in healthy Indian men: Effect of ethnicity

Sachidhanandam

Singh

Salhan

et al. 2010

Indian J Clin Biochem

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“…International guidelines recommend that every country must establish reference intervals for healthy individuals belonging to a group of homogeneous population. Considering enormous racial and ethnic diversity of Indian population, it is mandatory to establish reference intervals specific to Indian population [1].…”

Section: Measurement Of Prolactinmentioning

confidence: 99%

“…The values are obtained by observation or measurement of a particular type of quantity on reference individuals who are selected, as basis for comparison with individuals under clinical investigation, through the use of defined criteria [1].…”

Section: Introductionmentioning

confidence: 99%

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Establishment of Reference Interval of Serum Prolactin in an Indian Population

Lahiri

Baruah

Ghosh

et al. 2014

JCDR

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Background: Reference data on serum prolactin levels based on a representative Indian sample are still lacking. The western normative laboratory values used for clinical diagnosis may not be applicable to Indian population. The objective of the study was to measure the serum prolactin levels in healthy Indian male and female in order to establish reference interval and to compare with the available reference intervals. It is a crosssectional study done in West Bengal, India. Materials and Methods:Based on the history, clinical examination and laboratory investigations, serum prolactin levels of 1316 apparently healthy subjects were estimated by microplate immunoenzymometric assay using pooled serum.Statistical analysis was performed using SPSS software. Results:The serum prolactin levels for all ages were 10.7 ± 3 ng/ml in healthy male and 11.6 ± 2.8 ng/ml in healthy female. Decade-wise analysis of serum prolactin level in female showed a steady increase from 20-29 years to advancing decades until 4 th decade and thereafter declines steadily although it was not same for male. Conclusion:Our study will help each laboratory to formulate their own reference interval for prolactin. As of now they were dependent either on the values written on the kit-literature supplied by the reagent manufacturing company or the reference intervals of foreign population.

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“…In India, clinical laboratories use the reference values of commonly used analytes supplied by diagnostic reagent and equipment manufacturers in their instructions without giving details of the original source of the data [10]. Currently used RI for liver enzymes levels in India are mainly based upon western population and those provided by manufacturer of kits.…”

Section: Introductionmentioning

confidence: 99%

Hepatic Enzyme’s Reference Intervals and Their Modulating Factors in Western Indian Population

Maksane¹,

Dandekar²,

Shukla

et al. 2015

Ind J Clin Biochem

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The reference intervals (RIs) of serum aminotransferases and Gamma-glutamyl transferase (GGT) have been established many years ago. Recent RIs are not available. The prospective study was conducted to re-evaluate the RIs of liver enzymes and the effect of demographic and anthropometric variables on them in western Indian population. A total of 1059 blood donors comprised the study population. Anthropometry and serum liver enzymes levels were measured. Subjects were categorized into normal weight and overweight by using body mass index (BMI) and waist circumference (WC). For RI determination, non-parametric methodology recommended by IFCC/CLSI was adopted. Mann-Whitney test and Spearman's rank correlation were used for statistical analysis. Upper limit of normal reference value of liver enzymes were lower in female compared to male. (ALT-23.55 F vs 36.00 M, GGT-34.58 F vs 36.20 M) When RI of liver enzymes were calculated according to body mass index, the upper limit of normal of ALT and GGT were higher in overweight group compared to normal weight group. (ALT-38.00 vs 27.00 IU/L and GGT-37.59 vs 35.26 IU/L). In both male and female, liver enzymes correlated significantly with age. WC and BMI were positively correlated with AST, ALT and GGT in both subgroups and the correlation was stronger in male. Demographic factors should be considered for making liver enzyme tests more clinically relevant. Gender based partitioning should be adopted for serum alanine aminotransferase (ALT) and GGT reference values for Western Indian population.

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Whether western normative laboratory values used for clinical diagnosis are applicable to Indian population? An overview on reference interval

Abstract: ABSTRACT

Cited by 12 publications

References 47 publications

Evaluation of plasma hormone concentrations using Enzyme-Immunoassay/Enzyme-linked Immunosorbent assay in healthy Indian men: Effect of ethnicity

Evaluation of plasma hormone concentrations using Enzyme-Immunoassay/Enzyme-linked Immunosorbent assay in healthy Indian men: Effect of ethnicity

Establishment of Reference Interval of Serum Prolactin in an Indian Population

Hepatic Enzyme’s Reference Intervals and Their Modulating Factors in Western Indian Population

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