Whether histologic subtyping affect the oncological outcomes of patients with papillary renal cell carcinoma: evidence from a systematic review and meta-analysis

Xiong, Shengwei; Zhu, Weijie; Li, Xinfei; Yu, Yanfei; Yang, Kunlin; Zhang, Lei; Mi, Yue; Li, Xuesong; Zhou, Liqun

doi:10.21037/tau-21-329

Cited by 5 publications

(6 citation statements)

References 37 publications

(55 reference statements)

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“…15 WHO/ISUP nucleolar grade is a validated and currently used histologic parameter for PRCC 12 that provides better prognostication for oncologic outcomes, compared to the traditional histologic subtyping. 9,10,[29][30][31] Although the prognostic significance of WHO/ISUP grade was demonstrated in univariate analysis, we found, however, that WHO/ISUP grade was not significant in predicting survival when controlling for other variables, as already reported. 13,14,31 In the current practice, WHO/ISUP grade still remains a relevant histologic parameter in PRCC and we propose that ABCC2 can be further validated by using it in conjunction with the WHO/ISUP grade in independent PRCC cohorts for more accurate prognostication.…”

Section: Discussionsupporting

confidence: 53%

“…WHO/ISUP nucleolar grade is a validated and currently used histologic parameter for PRCC 12 that provides better prognostication for oncologic outcomes, compared to the traditional histologic subtyping 9,10,29–31 . Although the prognostic significance of WHO/ISUP grade was demonstrated in univariate analysis, we found, however, that WHO/ISUP grade was not significant in predicting survival when controlling for other variables, as already reported 13,14,31 .…”

Section: Discussionsupporting

confidence: 45%

“…To address this, PRCC was historically categorized into indolent type 1 and aggressive type 2, exclusively based on histomorphologic features 5 . Several issues rendered this subdivision of limited value, including: the occurrence of overlapping types 1 and 2 morphology in about half of the cases, leading to high interobserver reporting variability 6–8 ; the inclusion of other, more recently recognized tumour entities in the type 2 PRCC; for example, MiT‐family translocation RCC and fumarate hydratase (FH) deficient RCC 4 ; and the lack of consistent evidence of prognostic significance of type 1 versus type 2 division 9,10 . Consequently, the recent 2022 World Health Organization (WHO) classification eliminated the traditional histologic subtyping of PRCC 11 …”

Section: Introductionmentioning

confidence: 99%

“…5 Several issues rendered this subdivision of limited value, including: the occurrence of overlapping types 1 and 2 morphology in about half of the cases, leading to high interobserver reporting variability [6][7][8] ; the inclusion of other, more recently recognized tumour entities in the type 2 PRCC; for example, MiTfamily translocation RCC and fumarate hydratase (FH) deficient RCC 4 ; and the lack of consistent evidence of prognostic significance of type 1 versus type 2 division. 9,10 Consequently, the recent 2022 World Health Organization (WHO) classification eliminated the traditional histologic subtyping of PRCC. 11 Currently, WHO/ISUP (International Society of Urological Pathology) nucleolar grade is accepted as the only prognostic histopathologic marker for PRCC.…”

Section: Introductionmentioning

confidence: 99%

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ABCC2 brush‐border expression predicts outcome in papillary renal cell carcinoma: a multi‐institutional study of 254 cases

Castillo,

Masoomian,

Trpkov

et al. 2023

Histopathology

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AimsPapillary renal cell carcinoma (PRCC) histologic subtyping is no longer recommended in the 2022 WHO classification. Currently, WHO/ISUP nucleolar grade is the only accepted prognostic histologic parameter for PRCC. ABCC2, a renal drug transporter, has been shown to significantly predict outcomes in PRCC. In this study we evaluated the prognostic significance of ABCC2 IHC staining patterns in a large, multi‐institutional PRCC cohort and assessed the association of these patterns with ABCC2 mRNA expression.Methods and resultsWe assessed 254 PRCCs for ABCC2 IHC reactivity patterns that were stratified into negative, cytoplasmic, brush‐border <50%, and brush‐border ≥50%. RNA in situ hybridization (ISH) was used to determine the transcript level of each group. Survival analysis was performed with SPSS and GraphPad software. RNA‐ISH showed that the ABCC2 group with any brush‐border staining was associated with a significant increase in the transcript level, when compared to the negative/cytoplasmic group (P = 0.034). Both ABCC2 groups with brush‐border <50% (P = 0.024) and brush‐border ≥50% (P < 0.001) were also associated with worse disease‐free survival (DFS) in univariate analysis. Multivariate analysis showed that only ABCC2 IHC brush‐border (<50% and ≥50%) reactivity groups (P = 0.037 and P = 0.003, respectively), and high‐stage disease (P < 0.001) had a DFS of prognostic significance. In addition, ABCC2 brush‐border showed significantly worse DFS in pT1a (P = 0.014), pT1 (P = 0.013), ≤4 cm tumour (P = 0.041) and high stage (P = 0.014) groups, while a similar analysis with high WHO/ISUP grade in these groups was not significant.ConclusionABCC2 IHC brush‐border expression in PRCC correlates with significantly higher gene expression and also independently predicts survival outcomes.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionsupporting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

ABCC2 brush‐border expression predicts outcome in papillary renal cell carcinoma: a multi‐institutional study of 254 cases

Castillo,

Masoomian,

Trpkov

et al. 2023

Histopathology

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“…PRCC can be divided into two different subtypes, type 1 and type 2 (2). The systematic review and meta-analysis by Xiong et al collected a total of 4494 pRCC patients from 22 studies and showed that overall survival and cancer specific survival was worse in type 2 pRCC patients than in type 1 pRCC patients (22). Because the two tumours have many differences in biology, treatment options and prognosis, it is clinically important to distinguish accurately between type 1 and type 2 tumours preoperatively.…”

Section: Discussionmentioning

confidence: 99%

Differential Diagnosis of Type 1 and Type 2 Papillary Renal Cell Carcinoma Based on Enhanced CT Radiomics Nomogram

Gao

Wang

et al. 2022

Front. Oncol.

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ObjectivesTo construct a contrast-enhanced CT-based radiomics nomogram that combines clinical factors and a radiomics signature to distinguish papillary renal cell carcinoma (pRCC) type 1 from pRCC type 2 tumours.MethodsA total of 131 patients with 60 in pRCC type 1 and 71 in pRCC type 2 were enrolled and divided into training set (n=91) and testing set (n=40). Patient demographics and enhanced CT imaging characteristics were evaluated to set up a clinical factors model. A radiomics signature was constructed and radiomics score (Rad-score) was calculated by extracting radiomics features from contrast-enhanced CT images in corticomedullary phase (CMP) and nephrographic phase (NP). A radiomics nomogram was then built by incorporating the Rad-score and significant clinical factors according to multivariate logistic regression analysis. The diagnostic performance of the clinical factors model, radiomics signature and radiomics nomogram was evaluated on both the training and testing sets.ResultsThree validated features were extracted from the CT images and used to construct the radiomics signature. Boundary blurring as an independent risk factor for tumours was used to build clinical factors model. The AUC value of the radiomics nomogram, which was based on the selected clinical factors and Rad-score, were 0.855 and 0.831 in the training and testing sets, respectively. The decision curves of the radiomics nomogram and radiomics signature in the training set indicated an overall net benefit over the clinical factors model.ConclusionRadiomics nomogram combining clinical factors and radiomics signature is a non-invasive prediction method with a good prediction for pRCC type 1 tumours and type 2 tumours preoperatively and has some significance in guiding clinicians selecting subsequent treatment plans.

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Contemporary review of papillary renal cell carcinoma—current state and future directions

Castillo,

Trpkov,

Saleeb

2024

Virchows Arch

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Whether histologic subtyping affect the oncological outcomes of patients with papillary renal cell carcinoma: evidence from a systematic review and meta-analysis

Cited by 5 publications

References 37 publications

ABCC2 brush‐border expression predicts outcome in papillary renal cell carcinoma: a multi‐institutional study of 254 cases

ABCC2 brush‐border expression predicts outcome in papillary renal cell carcinoma: a multi‐institutional study of 254 cases

Differential Diagnosis of Type 1 and Type 2 Papillary Renal Cell Carcinoma Based on Enhanced CT Radiomics Nomogram

Contemporary review of papillary renal cell carcinoma—current state and future directions

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