Abstract:Objective: To investigate whether cytidine deaminase (CDD) of Mycoplasma hyorhinis induces gefitinib resistance in epidermal growth factor receptor (EGFR)-mutated lung cancer cells by decomposing gefitinib.
Method: Download the gene sequence of CDD from NCBI (Gene ID: 61335421) and redesign the CDD sequence. The prokaryotic expression vector and eukaryotic expression vector of CDD were constructed respectively. The H1650 cell line with stable expression of CDD(H1650-CDD) was obtained by lentiviral infection an… Show more
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