Abstract:BACKGROUND Timely diagnosis is recommended by the Brazilian Visceral Leishmaniasis (VL) Surveillance and Control Program to reduce case fatality. Attempts at assessing this topic in Brazil are scarce. OBJECTIVE This study aimed to describe where, when, and how the diagnosis of VL has been performed in a Brazilian endemic setting. METHODS Data of all autochthonous cases confirmed between 2011 and 2016 (N = 81) were recorded. The care-seeking itinerary until the confirmation of VL diagnosis was assessed among 57… Show more
“…A time delay of 2-3 months was chosen because the time between the onset of symptoms and the diagnosis of human VL in the municipality, as well as the time between the screening and euthanasia of a positive dog, was estimated in 25 and 41 days, respectively [24]. The offset term (the natural logarithm of the estimated dog population size), distance to the screening site, and demographic confounders were assumed to be constant over time and therefore were the same in all four variants.…”
Section: Factors Associated With Cvl Diagnosis-seeking Behavior At the Neighborhood Levelmentioning
Background
In Brazil, the transmission of Leishmania infantum in urban settings is closely related to infection among dogs, with occasional transmission to humans. Serological screening of dogs for Leishmania spp. infection on requests of their owners (passive case detection) represents a frequent, but little studied, practice within the scope of Brazilian public health. This study identified factors associated with canine visceral leishmaniasis (CVL) diagnosis-seeking behavior of dog owners in Rondonópolis (236,000 inhabitants), a municipality in Central-Western Brazil where VL is endemic. Also, we evaluated the profile of dog owners and their animals screened on free demand.
Methodology/Principal findings
Using mixed effects negative binomial regression, we modelled the number of dogs screened for Leishmania infection on free demand per neighborhood from 2011 to 2016 as a function of time-dependent predictors (current or recent canine seropositivity and human VL incidence), distance to the screening site, and demographic variables. We assessed potential delays in the effect of time-dependent predictors on the outcome. Among 12,536 dogs screened for Leishmania infection, 64.2% were tested during serosurveys and 35.8% were tested on free demand. Of these, 63.9% were positive. Uptake of screening under free demand was strongly associated with higher levels of canine seropositivity in the neighborhood (current or recent) and decreasing distance to the screening site. A subsample of dog owners (n = 93) who sought CVL screening between 2016 and 2017 were interviewed in more detail. Owners with better socioeconomic status and dogs with apparent CVL clinical manifestations prevailed among them.
Conclusions/Significance
To support timely CVL management, passive case detection along with awareness activities aimed at dog owners should be encouraged in endemic areas. Screening sites should be prioritized in accessible zones, as well as in socio-economically disadvantage areas. In parallel, CVL active case detection should be continued as a surveillance tool to guide control actions.
“…A time delay of 2-3 months was chosen because the time between the onset of symptoms and the diagnosis of human VL in the municipality, as well as the time between the screening and euthanasia of a positive dog, was estimated in 25 and 41 days, respectively [24]. The offset term (the natural logarithm of the estimated dog population size), distance to the screening site, and demographic confounders were assumed to be constant over time and therefore were the same in all four variants.…”
Section: Factors Associated With Cvl Diagnosis-seeking Behavior At the Neighborhood Levelmentioning
Background
In Brazil, the transmission of Leishmania infantum in urban settings is closely related to infection among dogs, with occasional transmission to humans. Serological screening of dogs for Leishmania spp. infection on requests of their owners (passive case detection) represents a frequent, but little studied, practice within the scope of Brazilian public health. This study identified factors associated with canine visceral leishmaniasis (CVL) diagnosis-seeking behavior of dog owners in Rondonópolis (236,000 inhabitants), a municipality in Central-Western Brazil where VL is endemic. Also, we evaluated the profile of dog owners and their animals screened on free demand.
Methodology/Principal findings
Using mixed effects negative binomial regression, we modelled the number of dogs screened for Leishmania infection on free demand per neighborhood from 2011 to 2016 as a function of time-dependent predictors (current or recent canine seropositivity and human VL incidence), distance to the screening site, and demographic variables. We assessed potential delays in the effect of time-dependent predictors on the outcome. Among 12,536 dogs screened for Leishmania infection, 64.2% were tested during serosurveys and 35.8% were tested on free demand. Of these, 63.9% were positive. Uptake of screening under free demand was strongly associated with higher levels of canine seropositivity in the neighborhood (current or recent) and decreasing distance to the screening site. A subsample of dog owners (n = 93) who sought CVL screening between 2016 and 2017 were interviewed in more detail. Owners with better socioeconomic status and dogs with apparent CVL clinical manifestations prevailed among them.
Conclusions/Significance
To support timely CVL management, passive case detection along with awareness activities aimed at dog owners should be encouraged in endemic areas. Screening sites should be prioritized in accessible zones, as well as in socio-economically disadvantage areas. In parallel, CVL active case detection should be continued as a surveillance tool to guide control actions.
“…A LV, também conhecida como calazar ou esplenomegalia tropical, é uma doença crônica e sistêmica, que tem como principais sintomas: anemia, febre de longa duração, perda de peso, aumento do fígado e baço (hepatoesplenomegalia), perda ou diminuição da força física (astenia), decréscimo da força muscular e fraqueza (adinamia) (Gomila et al, 2017;Luz et al, 2019). É considerada uma doença com alta letalidade na ausência de tratamento e isso deve-se à disseminação do parasito por diversos órgãos do corpo resultando em alterações hematológicas e infecções bacterianas, as quais contribuem para a ocorrência de um quadro séptico que tende a evoluir para o óbito (Daher et al, 2017;Bispo et al, 2020).…”
O nordeste brasileiro destaca-se por ter uma elevada prevalência de leishmaniose visceral (LV), sendo indicado como a principal região endêmica do Brasil. Tal fato torna de grande valia estudos epidemiológicos na região, visto que ajudam a traçar políticas públicas de saúde mais assertivas para o controle da LV. Nesse contexto, a presente investigação visa delinear o perfil epidemiológico da LV entre os anos de 2007 e 2019 e traçar um perfil de vulnerabilidade frente a doença no estado da Bahia. Trata-se de um estudo seccional, de caráter exploratório, descritivo, quantitativo e retrospectivo. Os dados utilizados relacionados a casos de LV no estado da Bahia são provenientes da base de dados SINAN (Sistema de Informação e Agravos de Notificação). A análise dos dados foi realizada utilizado o programa GraphPad Prism. A Bahia representa o terceiro estado com maior número de casos notificados de LV no nordeste brasileiro entre os anos de 2007 e 2019, com um total de 4.156 casos notificados. Uma análise espacial dessa distribuição demonstra que Juazeiro (146 casos) e Guanambi (125 casos) são os municípios baianos com o maior número de casos notificados no período avaliado. Através de uma análise estratificada dos dados observamos uma maior vulnerabilidade entre os indivíduos do sexo masculino, pardos, com baixo nível de escolaridade e na faixa etária de 1-4 anos. Com o presente trabalho, reforçamos o caráter endêmico da leishmaniose visceral no estado da Bahia e a necessidade de adotar políticas públicas de saúde visando o combate a LV.
Objective: To analyze the main municipal socioeconomic factors associated with the incidence of HVL in the state of Pernambuco, northeastern Brazil. Methods: It is a analytical cross-sectional study. Data on the incidence of HVL and socioeconomic factors were collected from 954 cases notified by the SINAN (National System of Notifiable Diseases) and SIM (Mortality Information System). The cases considered were reported by municipalities in the state of Pernambuco, Brazil, from 2005 to 2014. Statistical differences were analyzed by Pearson's correlation test, followed by multiple regression analysis. Significant differences were considered when p <0.05. Results: The FIRJAN Municipal Development Index was the variable that showed the most remarkable statistical robustness and strong negative association with the incidence of HVL. The municipal spending on health and residing in the metropolitan region also influenced its mean incidence rates. Conclusion: The indicators that had an influence on the performance of the incidence of LVH were the FIRJAN Municipal Development Index, health expenditure and residing in the metropolitan region.
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