Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review

Krela‐Kaźmierczak, Iwona; Zakerska-Banaszak, Oliwia; Skrzypczak-Zielińska, Marzena; Łykowska‐Szuber, Liliana; Szymczak-Tomczak, Aleksandra; Zawada, Agnieszka; Rychter, Anna M.; Ratajczak, Alicja Ewa; Skoracka, Kinga; Skrzypczak, Dorota; Marcinkowska, Emilia; Słomski, Ryszard; Dobrowolska, Agnieszka

doi:10.3390/nu14122520

Cited by 10 publications

(6 citation statements)

References 234 publications

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“…The lack of diversification and the focus on energy dense foods revealed by this study is not only specific to the Romanian population, but to the entire developed world. The consumption pattern identified through the questionnaire, focused on high intake of animal products at the expense of vegetables and fruits is characteristic of the Western dietary pattern, and has been the subject of many health-oriented studies [41,42,43,44].…”

Section: Resultsmentioning

confidence: 99%

Sustainable Nutrition for Increased Food Security – Case Study Romania

Bălan¹,

Gherman²,

Gherman³

et al. 2022

Preprint

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Food security is a matter of global concern, as the supply of food is one of the basic needs, ensuring the survival of the species. The trend of globalization and development of the global economy has shifted the responsible, local consumption patterns towards an increased homogeneity of diets, with food products being disconnected from their source, leading to two major results: (1) increased global consumption, driven by the extensive availability of affordable seasonal foods throughout the year and (2) increased uncertainty in the supply chain – susceptible to disruptions, causing food insecurity. To determine what the nutritional model is in the case of the present study – Romania – we developed a questionnaire of 32 questions and distributed it to 1,053 respondents from Romania. The survey was conducted during 2021 and 2022, both in urban and rural areas with the aim of investigating the consumption pattern of the population. The analysis of the questionnaire data reveals overconsumption of animal products, starchy vegetables and bread and pastry products. This nutritional pattern with a high intake in animal protein, correlated with a lack of diversification, is extremely unsustainable, having a negative impact on human health and environmental health.behaviour towards a careful approach to food, environment and personal health, aims to identify consumption patterns that have the potential to increase the sustainability of the food system and a positive correlation with food security. Adopting sustainable dietary patters, based on short supply chains and mindful consumption, has great potential in restoring food security and resilience to adversity.

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Section: Resultsmentioning

confidence: 99%

Sustainable Nutrition for Increased Food Security – Case Study Romania

Bălan¹,

Gherman²,

Gherman³

et al. 2022

Preprint

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show abstract

“…In contrast, Crohn’s Disease can cause transmural inflammation and affect any part of the gastrointestinal tract (most commonly, the terminal ileum or the perianal region) in a non-continuous type [ 59 , 60 ]. It is unclear what causes IBD, but it is thought to be caused by a combination of factors, including genetic, environmental, and especially dietary variables [ 61 , 62 , 63 ]. The association between nutrition and IBD has been extensively studied.…”

Section: Role Of Hydroxytyrosol In Ibdsmentioning

confidence: 99%

Hydroxytyrosol and Its Potential Uses on Intestinal and Gastrointestinal Disease

Arangia

Marino

Impellizzeri

et al. 2023

IJMS

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In recent years, the phytoconstituents of foods in the Mediterranean diet (MD) have been the subject of several studies for their beneficial effects on human health. The traditional MD is described as a diet heavy in vegetable oils, fruits, nuts, and fish. The most studied element of MD is undoubtedly olive oil due precisely to its beneficial properties that make it an object of interest. Several studies have attributed these protective effects to hydroxytyrosol (HT), the main polyphenol contained in olive oil and leaves. HT has been shown to be able to modulate the oxidative and inflammatory process in numerous chronic disorders, including intestinal and gastrointestinal pathologies. To date, there is no paper that summarizes the role of HT in these disorders. This review provides an overview of the anti-inflammatory and antioxidant proprieties of HT against intestinal and gastrointestinal diseases.

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“…The term “IBD” corresponds to a group of relapsing, chronically inflammatory gastrointestinal illnesses, notably Crohn's Disease and Ulcerative Colitis 78 . Over the past decade, as lifestyles and dietary practices became more westernized, IBDs expanded worldwide 79 . According to experimental data, excessive consumption of certain macronutrients in the modern food habit triggers an inflammatory response in the colon by preying on innate immune sensors and disrupting the metabolism of gut microbes.…”

Section: Mirna In the Progression Of Adsmentioning

confidence: 99%

“…78 Over the past decade, as lifestyles and dietary practices became more westernized, IBDs expanded worldwide. 79 According to experimental data, excessive consumption of certain macronutrients in the modern food habit triggers an inflammatory response in the colon by preying on innate immune sensors and disrupting the metabolism of gut microbes. Even though incidence is stabilizing in Western nations, the burden is still significant since prevalence exceeds 0.3%.…”

Section: Inflammatory Bowel Disorder (Ibd)mentioning

confidence: 99%

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Nag,

Mitra,

Tripathi

et al. 2023

Immunity Inflam & Disease

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BackgroundAutoimmune diseases (AD) are severe pathophysiological ailments that are stimulated by an exaggerated immunogenic response towards self‐antigens, which can cause systemic or site‐specific organ damage. An array of complex genetic and epigenetic facets majorly contributes to the progression of AD, thus providing significant insight into the regulatory mechanism of microRNA (miRNA). miRNAs are short, non‐coding RNAs that have been identified as essential contributors to the post‐transcriptional regulation of host genome expression and as crucial regulators of a myriad of biological processes such as immune homeostasis, T helper cell differentiation, central and peripheral tolerance, and immune cell development.AimsThis article tends to deliberate and conceptualize the brief pathogenesis and pertinent epigenetic regulatory mechanism as well as miRNA networks majorly affecting five different ADs namely rheumatoid arthritis (RA), type 1 diabetes, multiple sclerosis (MS), systemic lupus erythematosus (SLE) and inflammatory bowel disorder (IBD) thereby providing novel miRNA‐based theranostic interventions.Results & DiscussionPertaining to the differential expression of miRNA attributed in target tissues and cellular bodies of innate and adaptive immunity, a paradigm of scientific expeditions suggests an optimistic correlation between immunogenic dysfunction and miRNA alterations.ConclusionTherefore, it is not astonishing that dysregulations in miRNA expression patterns are now recognized in a wide spectrum of disorders, establishing themselves as potential biomarkers and therapeutic targets. Owing to its theranostic potencies, miRNA targets have been widely utilized in the development of biosensors and other therapeutic molecules originating from the same.

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Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review

Cited by 10 publications

References 234 publications

Sustainable Nutrition for Increased Food Security – Case Study Romania

Sustainable Nutrition for Increased Food Security – Case Study Romania

Hydroxytyrosol and Its Potential Uses on Intestinal and Gastrointestinal Disease

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

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