Where Do Epigenetics and Developmental Origins Take the Field of Developmental Psychopathology?

Nigg, Joel T.

doi:10.1007/s10802-015-0121-9

Cited by 20 publications

(22 citation statements)

References 109 publications

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“…Conversely, there is tentative evidence that genetic dysregulation of myelin development causally underlies specific psychiatric symptoms, particularly in schizophrenia (Hakak et al, ; Nave & Ehrenreich, ), a finding strengthened by animal studies that experimentally manipulate genes specifically in oligodendrocytes (Roy et al, ). Therefore, the most likely account of the association between neurodevelopment and psychopathology may be one of bidirectional and mutually exacerbating influences between the two (Nigg, ), but further neuroepidemiological studies are needed to explicitly address this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood

Vanes

Moutoussis

Ziegler

et al. 2019

Human Brain Mapping

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Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to unfold throughout adolescence, is reported to be abnormal in several psychiatric disorders. Here, we ask whether psychiatric vulnerability is linked to aberrant developmental myelination trajectories. We assessed a marker of myelin maturation, using magnetisation transfer (MT) imaging, in 10 major white matter tracts. We then investigated its relationship to the expression of a general psychopathology "p-factor" in a longitudinal analysis of 293 healthy participants between the ages of 14 and 24. We observed significant longitudinal MT increase across the full age spectrum in anterior thalamic radiation, hippocampal cingulum, dorsal cingulum and superior longitudinal fasciculus. MT increase in the inferior fronto-occipital fasciculus, inferior longitudinal fasciculus and uncinate fasciculus was pronounced in younger participants but levelled off during the transition into young adulthood. Crucially, longitudinal MT increase in dorsal cingulum and uncinate fasciculus decelerated as a function of mean p-factor scores over the study period. This suggests that an increased expression of psychopathology is closely linked to lower rates of myelin maturation in selective brain tracts over time. Impaired myelin growth in limbic association fibres may serve as a neural marker for emerging mental illness during the course of adolescence and early adulthood. K E Y W O R D S cingulum, general psychopathology, myelin, structural connectivity, uncinate fasciculus

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Section: Discussionmentioning

confidence: 99%

White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood

Vanes

Moutoussis

Ziegler

et al. 2019

Human Brain Mapping

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“…This is because exposure to high levels of stress hormones in utero can lead to Bepigeneticm odifications of DNA (i.e., molecular alterations to the structures surrounding the DNA molecule that influence its functioning). These epigenetic changes can have lasting effects on gene expression in ways that modify the developing structures and functional effectiveness of the young child's nervous system (Nigg 2016). Epigenetic alterations can increase risk for hypo-or hyper-reactivity, deficits in self-regulation, and psychopathology (Mulder et al in press; Neuenschwander and Oberlander in press).…”

Section: Family Diversification Of Adhd Symptoms: Gene-environment Prmentioning

confidence: 99%

Parents’ and Children’s ADHD in a Family System

Deater‐Deckard

2017

J Abnorm Child Psychol

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ADHD symptoms "run in families". However, relatively little is known about the ways in which parents' symptoms might additively and interactively work with the parenting environment, to influence (and be influenced by) the developmental trajectory of symptoms in children and adolescents. In this commentary on the special section addressing this gap in knowledge, emphasis is placed on the importance of replicating and extending family-wide studies of ADHD symptoms and etiology. The current papers exemplify the leading-edge of such efforts, demonstrating the feasibility and rigor with which studies are being conducted, utilizing longitudinal and experimental designs. Families and parenting environments operate as a system in which individuals influence each other's symptoms and functioning. In so doing, parents produce tremendous variability within (as well as between) each family in individuals' ADHD symptoms from childhood through adulthood, via gene-environment transactions that may even begin during prenatal development.

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“…stress hormones) and lead to changes in gene activities but not to changes in the DNA sequence [9]. Maternal experiences and environmental factors in the perinatal period can increase or reduce gene expression, for example through DNA methylation or histone modification, thereby inducing longterm changes to various biological systems [2,10]. However, the understanding of the precise relationship between adverse intrauterine environmental factors and their potential impact on the physical or mental health of the child as well as the specific underlying mechanisms is still very limited and is far from fully elucidated.…”

Section: Consequences and Possible Predictors Of Health-damaging Behamentioning

confidence: 99%

Consequences and Possible Predictors of Health-damaging Behaviors and Mental Health Problems in Pregnancy – A Review

Ulrich

Petermann

2016

Geburtshilfe Frauenheilkd

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!In recent decades, the understanding of the short and longer term effects of health-damaging behaviors and mental health problems in pregnant women and the underlying mechanisms of these behaviors and illnesses has significantly increased. In contrast, little is known about the factors affecting individual pregnant women which contribute to health-damaging behaviors and mental illness. The aim of this paper was therefore to summarize the current state of research into the consequences of nicotine and alcohol consumption, malnutrition, excessive weight gain or obesity, and impaired mental health (depression and anxiety) during pregnancy. In addition, the characteristics of pregnant women which increase their risk of developing such behaviors or mental disorders are described. A better knowledge of these risks should make it easier for clinicians to identify cases at risk early on and put measures of support in place. A review of the literature has shown that certain characteristics of pregnant women (e.g. her relationship with her partner, a previous history of mental illness prior to pregnancy) are associated with various healthdamaging behaviors as well as with impaired mental health. Affected women often show an accumulated psychosocial stress which was already present prior to the pregnancy and which may persist even after the birth of the child. Zusammenfassung Consequences and Possible Predictors of Health-damaging Behaviors and Mental Health Problems in Pregnancy -A ReviewAuswirkungen und mögliche Prädiktoren gesundheitsschädigender Verhaltensweisen und psychischer Beeinträchtigungen in der Schwangerschaft -ein Überblick

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Where Do Epigenetics and Developmental Origins Take the Field of Developmental Psychopathology?

Cited by 20 publications

References 109 publications

White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood

White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood

Parents’ and Children’s ADHD in a Family System

Consequences and Possible Predictors of Health-damaging Behaviors and Mental Health Problems in Pregnancy – A Review

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