Where do all the red blood cells (RBCs) go? Results of a survey of RBC use in <scp>E</scp>ngland and North Wales in 2014

Tinegate, Hazel; Pendry, Kate; Murphy, Michael; Babra, Paul Singh; Grant‐Casey, John; Hopkinson, Cathy; Hyare, Jot; Rowley, Megan; Seeney, Frances; Watson, Douglas; Wallis, Jonathan P.

doi:10.1111/trf.13342

Cited by 79 publications

(99 citation statements)

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“…In contrast, the transfusion demand for red blood cell concentrates (RBCs) is more influenced by changes in transfusion practice [2][3][4][5]. In recent years all western countries observed a decrease in transfusion demand [4][5][6][7][8][9]. This is in part driven by the availability of prospective randomized trial data showing that liberal transfusion strategies (maintaining the patient's hemoglobin levels above 10 g/dl) do not seem to be of benefit for patients [10], and has further been enforced by implementation of the 'patient blood management program', which comprises a number of different measurements including optimizing the preoperative hemoglobin level of the patient, reduction of perioperative blood loss, and a restrictive transfusion strategy [11].…”

Section: Introductionmentioning

confidence: 99%

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Longitudinal Changes in the Blood Supply and Demand in North-East-Germany 2005-2015

Schönborn¹,

Weitmann²,

Greger³

et al. 2017

Transfus Med Hemother

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Background: Securing future blood supply is a major issue of transfusion safety. In this prospective 10-year longitudinal study we enrolled all blood donation services and hospitals of the federal state Mecklenburg-Western Pomerania. Methods and Results: From 2005 to 2015 (time period with major demographic effects), whole blood donation numbers declined by 18%. In male donors this paralleled the demographic change, while donation rates of females declined 12.4% more than expected from demography. In parallel, red cell transfusion rates/1,000 population decreased from 2005 to 2015 from 56 to 51 (-8.4%), primarily due to less transfusions in patients >60 years. However, the transfusion demand declined much less than blood donation numbers: -13.5% versus -18%, and the population >65 years (highest transfusion demand) will further increase. The key question is whether the decline in transfusion demand observed over the previous years will further continue, hereby compensating for reduced blood donation numbers due to the demographic change. The population structure of Mecklenburg-Western Pomerania reflects all Eastern German federal states, while the Western German federal states will reach similar ratios of age groups 18-64 years / ≥65 years about 10 years later. Conclusions: Regular monitoring of age- and sex-specific donation and transfusion data is urgently required to allow transfusion services strategic planning for securing future blood supply.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Longitudinal Changes in the Blood Supply and Demand in North-East-Germany 2005-2015

Schönborn¹,

Weitmann²,

Greger³

et al. 2017

Transfus Med Hemother

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“…With increasing life expectancy and the consequent increase of age-related diseases, the demand for blood and blood products will concomitantly raise in future [43][44][45].…”

Section: Patient Blood Management: Future Sustainability?mentioning

confidence: 99%

Patient blood management

Choorapoikayil

Zacharowski

Meybohm

2016

Current Opinion in Anaesthesiology

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“…Approximately 66,000 units of blood (known as packed red cells) are given annually in the UK maternity setting. 11 This equates to £7M per year 12 without considering additional health-care costs involved in the administration of blood or the financial consequences of maternal acute illness. Thus, any reduction in the amount of blood required for obstetrics could significantly reduce the cost of blood transfusions.…”

Section: Donor Blood Transfusion In Obstetricsmentioning

confidence: 99%

“…It was assumed that in the case of an acute transfusion reaction, the transfusion would be discontinued. 11 10. Infant health.…”

Section: Assumptionsmentioning

confidence: 99%

A randomised controlled trial and economic evaluation of intraoperative cell salvage during caesarean section in women at risk of haemorrhage: the SALVO (cell SALVage in Obstetrics) trial

Khan

Moore

Wilson

et al. 2018

Health Technol Assess

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This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: journals.library@nihr.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: http://www.nets.nihr.ac.uk/programmes/hta This reportThe research reported in this issue of the journal was funded by the HTA programme as project number 10/57/32. The contractual start date was in October 2012. The draft report began editorial review in December 2016 and was accepted for publication in March 2017. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health. Published by t...

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Where do all the red blood cells (RBCs) go? Results of a survey of RBC use in England and North Wales in 2014

Abstract: Our findings confirm the previous regional finding that the percentage of RBC units that are transfused to surgical patients in England and North Wales is now much lower than for medical patients and suggest that PBM initiatives should now focus on medical patients.

Cited by 79 publications

References 17 publications

Longitudinal Changes in the Blood Supply and Demand in North-East-Germany 2005-2015

Longitudinal Changes in the Blood Supply and Demand in North-East-Germany 2005-2015

Patient blood management

A randomised controlled trial and economic evaluation of intraoperative cell salvage during caesarean section in women at risk of haemorrhage: the SALVO (cell SALVage in Obstetrics) trial

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