Where Did the Dura Mater Come from?

Suh, Dae Chul

doi:10.5469/neuroint.2020.00045

Cited by 8 publications

(7 citation statements)

References 14 publications

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“…24,25 One potential explanation for the different clinical and genomic features of supratentorial versus infratentorial NF2 mutant meningiomas is the divergent embryonic development of the meninges by location. 14 Studies of animal models have demonstrated that the meninges of the forebrain are derived from neural crest cells, arising from the ectoderm, whereas those surrounding the midbrain and hindbrain are derived from mesodermal cells. 26,27 Migrating neural crest cells driving the formation of the meninges of the ventral brain regions and mesodermal cells driving dorsal and posterior meninges development are also observed in humans.…”

Section: Discussionmentioning

confidence: 99%

“…8 Interestingly, the embryological derivation of the meninges is also distinct based on location, such that the forebrain meninges originate from ectoderm-derived neural crest cells, whereas the meninges of the mid-and hindbrain arise from mesodermal cells. 14 These observations suggest that the embryonic origin of the meninges determines the somatic mutations that they might be susceptible to during meningioma formation. For example, meninges posterior to the coronal suture, which originate from the mesoderm, form due to NF2 somatic mutations.…”

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confidence: 97%

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Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas

Tabor

O’Brien

Vasandani

et al. 2023

Journal of Neurosurgery

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OBJECTIVE Mutations in NF2 are the most common somatic driver mutation in sporadic meningiomas. NF2 mutant meningiomas preferentially arise along the cerebral convexities—however, they can also be found in the posterior fossa. The authors investigated whether NF2 mutant meningiomas differ in clinical and genomic features based on their location relative to the tentorium. METHODS Clinical and whole exome sequencing (WES) data for patients who underwent resection of sporadic NF2 mutant meningiomas were reviewed and analyzed. RESULTS A total of 191 NF2 mutant meningiomas were included (165 supratentorial, 26 infratentorial). Supratentorial NF2 mutant meningiomas were significantly associated with edema (64.0% vs 28.0%, p < 0.001); higher grade—i.e., WHO grade II or III (41.8% vs 3.9%, p < 0.001); elevated Ki-67 (55.0% vs 13.6%, p < 0.001); and larger volume (mean 45.5 cm3 vs 14.9 cm3, p < 0.001). Furthermore, supratentorial tumors were more likely to harbor the higher-risk feature of chromosome 1p deletion (p = 0.038) and had a larger fraction of the genome altered with loss of heterozygosity (p < 0.001). Infratentorial meningiomas were more likely to undergo subtotal resection than supratentorial tumors (37.5% vs 15.8%, p = 0.021); however, there was no significant difference in overall (p = 0.2) or progression-free (p = 0.4) survival. CONCLUSIONS Supratentorial NF2 mutant meningiomas are associated with more aggressive clinical and genomic features as compared with their infratentorial counterparts. Although infratentorial tumors have higher rates of subtotal resection, there is no associated difference in survival or recurrence. These findings help to better inform surgical decision-making in the management of NF2 mutant meningiomas based on location, and may guide postoperative management of these tumors.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas

Tabor

O’Brien

Vasandani

et al. 2023

Journal of Neurosurgery

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“…Dural AVF is considered to be an acquired disease and may develop by neoangiogenesis due to various etiologies, including venous sinus thrombosis, trauma, and surgery [ 28 ]. Dural AVF considering different presentations according to the lesion location and venous drainage pattern may be associated with different orientations in the development of the neural crest and mesoderm [ 29 ]. Spinal AVM and/or fistula may have similar aspects but different development compared to the intracranial dura [ 30 ].…”

Section: Composition Of An Rnvd Panel and Prevalence Of Each Disease In Koreamentioning

confidence: 99%

Rare Neurovascular Diseases in Korea: Classification and Related Genetic Variants

et al. 2021

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Rare neurovascular diseases (RNVDs) have not been well-recognized in Korea. They involve the central nervous system and greatly affect the patients' lives. However, these diseases are difficult to diagnose and treat due to their rarity and incurability. We established a list of RNVDs by referring to the previous literature and databases worldwide to better understand the diseases and their current management status. We categorized 68 RNVDs based on their pathophysiology and clinical manifestations and estimated the prevalence of each disease in Korea. Recent advances in genetic, molecular, and developmental research have enabled further understanding of these RNVDs. Herein, we review each disease, while considering its classification based on updated pathologic mechanisms, and discuss the management status of RNVD in Korea.

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“…A ventrally-located orientation of SEDAVF with a large confluent venous pouch, which embryologically mimics a cavernous sinus DAVF, may preclude a surgical approach. 3,15,16 We present 12 cases of SEDAVF with venous congestive myelopathy (VCM) and describe 3 different embolization tactics to overcome the distance from the microcatheter tip to the epidural venous sac or intradural reflux point. We also evaluated clinical outcomes based on the pain, sensory, motor, and sphincter (PSMS) scale 17 and modified Rankin score (mRS) before and after endovascular treatment.…”

Section: Introductionmentioning

confidence: 99%

Embolization Tactics of Spinal Epidural Arteriovenous Fistulas

et al. 2021

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Purpose: Spinal epidural arteriovenous fistulas (SEDAVFs) show an epidural venous sac often with venous congestive myelopathy (VCM) due to intradural reflux at a remote level to which a transarterial approach would be difficult. We present 12 cases of SEDAVF with VCM and describe 3 main tactics for effective transarterial embolization.Materials and Methods: Among 152 patients with spinal vascular malformations diagnosed in our tertiary hospital between 1993 and 2019, 12 SEDAVF patients with VCM were included. Three different transarterial embolization tactics were applied according to the vascular configuration and microcatheter accessibility. We evaluated treatment results and clinical outcomes before and after treatment.Results: Transarterial embolization with glue (20–30%) was performed in all patients. The embolization tactics applied in 12 patients were preferential flow (n=2), plug-and-push (n=6), and filling of the venous sac (n=4). Total occlusion of the SEDAVF, including intradural reflux, was achieved in 11 (91.7%) of 12 patients, and partial occlusion was achieved in 1 patient. No periprocedural complications were reported. Spinal cord edema was improved in all patients for an average of 18 months after treatment. Clinical functional outcome in terms of the pain, sensory, motor, and sphincter scale and modified Rankin scores improved during a mean 25-month follow-up (6.3 vs. 3.3, P=0.002; 3.6 vs. 2.3, P=0.002, respectively).Conclusion: Endovascular treatment for 12 SEDAVF patients with VCM achieved a total occlusion rate of 91.7% without any periprocedural complication. The combined embolization tactics can block intradural reflux causing VCM, resulting in overall good clinical outcomes.

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Where Did the Dura Mater Come from?

Cited by 8 publications

References 14 publications

Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas

Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas

Rare Neurovascular Diseases in Korea: Classification and Related Genetic Variants

Embolization Tactics of Spinal Epidural Arteriovenous Fistulas

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