Where are we today with Helicobacter pylori infection among healthy children in Saudi Arabia?

Al–Hussaini, Abdulrahman; Jurayyan, Abdullah N Al; Bashir, Salman; Alshahrani, Dayel

doi:10.4103/sjg.sjg_531_18

Cited by 15 publications

(21 citation statements)

References 40 publications

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“…[ 26 ] To determine whether the socioeconomic status has an impact on micronutrients deficiency, we collected data on four main indicators, namely parents’ educational level, family income, habitation, and parents’ jobs, as we described in more detail previously. [ 27 ]…”

Section: Methodsmentioning

confidence: 99%

Vitamin D and iron deficiencies among Saudi children and adolescents: A persistent problem in the 21^st century

Al–Hussaini

Alshehry

AlDehaimi

et al. 2022

Saudi J Gastroenterol

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Background: Although several studies have reported on the prevalence of micronutrients in Saudi Arabia, most frequently vitamin D and iron, they are either old or hospital- or primary health care center-based. The objectives of our study were to provide more updated data on the prevalence rate of micronutrients deficiency among the Saudi general pediatric population and to determine if there is an association between micronutrients deficiency and undernutrition. Methods: The present study is part of a cross-sectional mass screening study, “Exploring the Iceberg of Celiacs in Saudi Arabia” conducted among school-aged children (6–16 years) in 2014–2015. A sample of 7,931 children aged 6–16 years was randomly selected. We identified thin children [body mass index (BMI) z-score <−2 SD, for age and gender], using the WHO reference 2007. A case-control study was performed, where the sera of 182 thin children (cases) and 393 normal BMI children (controls) were tested for levels of iron, ferritin, vitamin D, zinc, selenium, and copper. Results: The prevalence of thinness was 3.5%. The two most common micronutrients deficient among Saudi children with normal BMI were iron (20%) and vitamin D (78%). Vitamin D levels were significantly higher among boys as compared to girls (39.6 nmol/L vs. 31.15 nmol/L; P < 0.001). Deficiency of copper, zinc, and selenium occurred in 0.25%, 1%, and 7.4% of the children with normal BMI. Comparisons between the cases and controls did not show statistically significant differences. Conclusion: Vitamin D and iron deficiencies are still common forms of malnutrition in the Saudi community, that have remained unchanged over the past 20–30 years, while the intake of trace elements (zinc, copper, and selenium) is adequate as evident by normal serum levels in the vast majority of the investigated children. We could not observe a correlation between undernutrition and micronutrient deficiencies.

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Section: Methodsmentioning

confidence: 99%

Vitamin D and iron deficiencies among Saudi children and adolescents: A persistent problem in the 21^st century

Al–Hussaini

Alshehry

AlDehaimi

et al. 2022

Saudi J Gastroenterol

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“… 12 Importantly, the variation in the prevalence of H. pylori infection has been reported in different regions of Saudi Arabia. 13 , 14 Few studies on H. pylori in the country have shown a high prevalence in various age groups of patients. 13 Recently, variation in H. pylori infection among Saudi children was also seen in metropolitan cities such as Jeddah and Riyadh.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of hematological parameters in dyspepsia patients infected with Helicobacter pylori

Alshomar

2022

SMJ

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The data of dyspepsia and epigastric pain patients were derived from the hospital based registration system between 2020-2021. Logistic regression models were used to investigate the correlation between the onset of H. pylori infection and anemia.Results: Among 810 enrolled patients, there were 202 )24.9%( patients with H. pylori infection and 144 )17.8%( with anemia. The prevalence of anemia in the H. pylori )+( group was not statistically higher than the H. pylori )-( group after adjusting age, red blood cell count, serum ferritin, Original Articlemean corpuscular volume, platelet count, and mean corpuscular hemoglobin )p>0.05(. The level of hemoglobin was almost identical in both the H. pylori )+( group and the H. pylori )-( group )p>0.05(. Conclusion:The findings show that H. pylori infection may not be related to anemia in dyspepsia patients from the Central region of KSA.

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“…Another point needed to be mentioned is that compared with symptomatic children, the H. pylori-Ab detection rate is mildly lower in asymptomatic ones according to a systematic review about the H. pylori infection of children, and the same conclusion is disclosed in Saudi Arabia study. 23 Therefore, we focused on the in-depth study of apparently healthy infants and toddlers with H. pylori infection in this article. Finally, low income and poor sanitation are two risk factors for H. pylori infection of children.…”

Section: Discussionmentioning

confidence: 99%

Association of Helicobacter pylori Infection with Vitamin D Deficiency in Infants and Toddlers

Gao

Zhao

Zhang

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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Helicobacter pylori (H. pylori), a gram-negative pathogen, has been shown to colonize multiple organs and cause various forms of extra-gastrointestinal diseases. The association of H. pylori infection with vitamin D status in apparently healthy children remained unclear; therefore, we investigated the relationship between vitamin D and H. pylori infection among apparently healthy infants and toddlers. In this large cross-sectional study, the examination data of children were collected from January 2013 to September 2017 in the Center for Children's Health Care. Among these children, 6,896 infants and toddlers were screened for our study. Helicobacter pylori infection and vitamin D status were the main indicators, and micronutrients (zinc, iron, copper, magnesium), and growth parameters (height, weight, and weight for age Z score [WAZ], height for age Z score [HAZ]) were also analyzed in this study. Among the 6,896 infants and toddlers, the detection rate of H. pylori seropositivity was 30.6%. The prevalence of vitamin D deficiency in H. pylori seropositive and seronegative groups was 20.7% and 12.1%, respectively (P < 0.001). The logistic regression analysis suggested children with H. pylori-positive antibody were 2.06 times more likely to be vitamin D deficient compared with children who had negative H. pylori antibody (odds ratio: 2.06; 95% CI: 1.77, 2.38) after controlling for confounding factors. These data suggested that there was a significant association between H. pylori seropositivity and vitamin D deficiency in children aged 6-36 months, which would make a contribution to the treatment and monitoring of vitamin D deficiency and H. pylori infection.

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Where are we today with Helicobacter pylori infection among healthy children in Saudi Arabia?

Cited by 15 publications

References 40 publications

Vitamin D and iron deficiencies among Saudi children and adolescents: A persistent problem in the 21^st century

Vitamin D and iron deficiencies among Saudi children and adolescents: A persistent problem in the 21^st century

Evaluation of hematological parameters in dyspepsia patients infected with Helicobacter pylori

Association of Helicobacter pylori Infection with Vitamin D Deficiency in Infants and Toddlers

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Where are we today with Helicobacter pylori infection among healthy children in Saudi Arabia?

Cited by 15 publications

References 40 publications

Vitamin D and iron deficiencies among Saudi children and adolescents: A persistent problem in the 21st century

Vitamin D and iron deficiencies among Saudi children and adolescents: A persistent problem in the 21st century

Evaluation of hematological parameters in dyspepsia patients infected with Helicobacter pylori

Association of Helicobacter pylori Infection with Vitamin D Deficiency in Infants and Toddlers

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Product

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Vitamin D and iron deficiencies among Saudi children and adolescents: A persistent problem in the 21^st century

Vitamin D and iron deficiencies among Saudi children and adolescents: A persistent problem in the 21^st century