Where and when should natural killer cells be tested in women with repeated implantation failure?

Santillan, Isabel; Verdú, Victoria; Menchero, Santiago; Arenas, José Manuel Bajo

doi:10.1016/j.jri.2013.12.096

Cited by 7 publications

(16 citation statements)

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“…12,13 The anomalous Uterine NK cells measured via endometrial biopsy is also proved in women suffering from idiopathic RIF, though cut off values still require standardization. 14 However, there is still no definite evidence to suggest that these directly cause the implantation failure. Therefore, the current treatment of RIF targeted at immune is largely empirical and based on poor scientific evidence.…”

Section: Discussionmentioning

confidence: 99%

“…The abnormal immunological profile, such as peri‐implantation peripheral natural killer (NK) cell level, activity and Th1/Th2/Treg ratio, has been found in women with already established RIF 12,13 . The anomalous Uterine NK cells measured via endometrial biopsy is also proved in women suffering from idiopathic RIF, though cut off values still require standardization 14 . However, there is still no definite evidence to suggest that these directly cause the implantation failure.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical outcome of intrauterine administration of peripheral mononuclear cells or human chorionic gonadotropin in unexplained implantation failure

Mei

Yuan

Jiang

et al. 2022

American J Rep Immunol

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Problem: Intrauterine administration of autologous peripheral blood mononuclear cells (PBMCs) or human chorionic gonadotropin (hCG) has been proposed to facilitate embryo implantation, while its effect on clinical outcome of women with previous implantation failure (RIF) in frozen/thawed embryo transfer (FET) cycles is still unclear. Method of study: A total 523 patients having not experienced successful clinical pregnancy were enrolled in our study, including 207 repeat implantation failure (RIF) patients, and 316 patients with previous implantation failures but failed to meet the diagnostic criteria for RIF (non-RIF). Autologous PBMCs were cultured with hCG for 4 h in the hCG-activated PBMC-treated group (n = 73 in RIF patients, n = 112 in non-RIF patients), and then intrauterine administered 2 days before FET. In the hCGtreated group (n = 67 in RIF patients, n = 100 in non-RIF patients), recombinant hCG was administered 2 days before FET. The control group (n = 67 in RIF patients, n = 104 in non-RIF patients) underwent FET without intrauterine administration. Results:In RIF patients, the clinical pregnancy rate of the above three groups are 56.16%, 53.73%, and 43.28%, respectively (p = .276). The implantation rate and live birth rate showed no significant differences (p > .05). For non-RIF patients, higher clinical pregnancy rate was also seen in PBMC intrauterine group (57.15%) and hCG intrauterine group (58.00%) than controls (50.96%) but without statistical significance.There were no significant differences of implantation rate and live birth rate (p > .05). Conclusion:Intrauterine administration of hCG-activated PBMC and hCG did not improve clinical outcomes for both RIF and non-RIF patients before FET embryo transfer. K E Y W O R D Sautologous peripheral blood mononuclear cells, human chorionic gonadotropin, in vitro fertilization and embryo transfer, repeat implantation failure

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical outcome of intrauterine administration of peripheral mononuclear cells or human chorionic gonadotropin in unexplained implantation failure

Mei

Yuan

Jiang

et al. 2022

American J Rep Immunol

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“…Numerous studies have demonstrated an association between significant increase on uNK and RIF . Although the percentage of uNK is a relatively crude assessment and do not reflect their function, the observed differences in numbers still may be an indication of an underlying pathologic condition affecting their function and therefore requires an intervention to rectify these changes.…”

Section: Discussionmentioning

confidence: 99%

“…The cutoff value is quite controversial, as values can be varying due to different methods used for assessment, the variation of reagents purchased from different companies, and the methods used for quantification. For example, some reports suggest normal values from 5% to 13.9% of the total stromal cells; or from 100 cells to 250 cells at 400× magnification per field. Furthermore, in the majority of the studies, the various normal range of uNK was determined based on healthy volunteers with a very small number of samples.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment with intrauterine delivery of dexamethasone for repeated implantation failure

Zhang

Huang

et al. 2017

American J Rep Immunol

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“…These measurements became possible by imaging uterine NK cells with immunohistochemical staining. Although thresholds still require standardization, NK cell analysis may ultimately prove useful for women suffering from idiopathic repeated implant failure [26]. On the other hand, a meta-analysis by Seshadri et al (2014), aimed at determining the role of NK cells in both peripheral blood and the uterus in infertility, revealed some conflicting data on their role.…”

mentioning

confidence: 99%

Morphological and Molecular Biological Determinants of Repeated Implantation Failure

Оразов¹,

Локшин²,

Silantyeva³

et al. 2020

THE NATIONAL ACADEMY OF SCIENCES OF THE REPUBLIC OF KAZAKHSTAN

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Қазақстан Республикасы Ұлттық ғылым академиясы "ҚР ҰҒА Хабаршысы" ғылыми журналының Web of Science-тің жаңаланған нұсқасы Emerging Sources Citation Index-те индекстелуге қабылданғанын хабарлайды. Бұл индекстелу барысында Clarivate Analytics компаниясы журналды одан əрі the Science Citation Index Expanded, the Social Sciences Citation Index жəне the Arts & Humanities Citation Index-ке қабылдау мəселесін қарастыруда. Web of Science зерттеушілер, авторлар, баспашылар мен мекемелерге контент тереңдігі мен сапасын ұсынады. ҚР ҰҒА Хабаршысының Emerging Sources Citation Index-ке енуі біздің қоғамдастық үшін ең өзекті жəне беделді мультидисциплинарлы контентке адалдығымызды білдіреді. НАН РК сообщает, что научный журнал «Вестник НАН РК» был принят для индексирования в Emerging Sources CitationIndex, обновленной версии Web of Science. Содержание в этом индексировании находится в стадии рассмотрения компанией Clarivate Analytics для дальнейшего принятия журнала в the Science Citation Index Expanded, the Social Sciences Citation Index и the Arts & Humanities Citation Index. Web of Science предлагает качество и глубину контента для исследователей, авторов, издателей и учреждений. Включение Вестника НАН РК в Emerging Sources Citation Index демонстрирует нашу приверженность к наиболее актуальному и влиятельному мультидисциплинарному контенту для нашего сообщества.

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Where and when should natural killer cells be tested in women with repeated implantation failure?

Cited by 7 publications

References 0 publications

Clinical outcome of intrauterine administration of peripheral mononuclear cells or human chorionic gonadotropin in unexplained implantation failure

Clinical outcome of intrauterine administration of peripheral mononuclear cells or human chorionic gonadotropin in unexplained implantation failure

Successful treatment with intrauterine delivery of dexamethasone for repeated implantation failure

Morphological and Molecular Biological Determinants of Repeated Implantation Failure

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