When to Start and Stop Bone-Protecting Medication for Preventing Glucocorticoid-Induced Osteoporosis

Hayes, Kaleen N; Baschant, Ulrike; Hauser, Barbara; Burden, Andrea M.; Winter, Elizabeth M.

doi:10.3389/fendo.2021.782118

Cited by 17 publications

(11 citation statements)

References 87 publications

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“…Chun-Yuan Chen et al collected EVs from human-urine-derived stem cells (USG), and then injected these EVs into a mouse model of osteoporosis, which proved that these EVs can enhance bone formation and inhibit osteoclast resorption; the specific mechanism is the enrichment of CTHRC1 and OPG proteins are necessary for inducing bone formation and inhibiting osteoclast resorption. Therefore, USC-EVs can be said to be a very promising method of treatment for osteoporosis [ 9 ]. Dawei Liu et al demonstrated that RNF146 in circulating apoptotic bodies can treat osteoporosis [ 21 ].…”

Section: The Potential Therapeutic Effects Of Evs In Osteoporosismentioning

confidence: 99%

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The Role of Extracellular Vesicles in Osteoporosis: A Scoping Review

et al. 2022

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As an insidious metabolic bone disease, osteoporosis plagues the world, with high incidence rates. Patients with osteoporosis are prone to falls and becoming disabled, and their cone fractures and hip fractures are very serious, so the diagnosis and treatment of osteoporosis is very urgent. Extracellular vesicles (EVs) are particles secreted from cells to the outside of the cell and they are wrapped in a bilayer of phospholipids. According to the size of the particles, they can be divided into three categories, namely exosomes, microvesicles, and apoptotic bodies. The diameter of exosomes is 30–150 nm, the diameter of microvesicles is 100–1000 nm, and the diameter of apoptotic bodies is about 50–5000 nm. EVs play an important role in various biological process and diseases including osteoporosis. In this review, the role of EVs in osteoporosis is systematically reviewed and some insights for the prevention and treatment of osteoporosis are provided.

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Section: The Potential Therapeutic Effects Of Evs In Osteoporosismentioning

confidence: 99%

“…Although bisphosphonates have satisfactory therapeutic effects, they also have some side effects. Therefore, new prevention and treatment methods for osteoporosis are critical [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Extracellular Vesicles in Osteoporosis: A Scoping Review

et al. 2022

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“…Prevention and management of GIOP is addressed in several guidelines and has been extensively reviewed in other articles and is beyond the scope of this review (141)(142)(143)(144). It is worth highlighting that a dual-energy X-ray absorptiometry (DXA) scan for BMD measurement is required in the majority of cases for a fracture risk assessment.…”

Section: Bone Preserving Treatments In Vasculitis: the Role Of Steroi...mentioning

confidence: 99%

The Impact of High Dose Glucocorticoids on Bone Health and Fracture Risk in Systemic Vasculitides

2022

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Systemic vasculitides are a range of conditions characterized by inflammation of blood vessels which may manifest as single organ or life-threatening multisystem disease. The treatment of systemic vasculitis varies depending on the specific disease but historically has involved initial treatment with high dose glucocorticoids alone or in conjunction with other immunosuppressive agents. Prolonged glucocorticoid treatment is frequently required as maintenance treatment. Patients with small and large vessel vasculitis are at increased risk of fracture. Osteoporosis may occur due to intrinsic factors such as chronic inflammation, impaired renal function and to a large extent due to pharmacological therapy with high dose glucocorticoid or combination treatments. This review will outline the known mechanism of bone loss in vasculitis and will summarize factors attributing to fracture risk in different types of vasculitis. Osteoporosis treatment with specific consideration for patients with vasculitis will be discussed. The use of glucocorticoid sparing immunosuppressive agents in the treatment of systemic vasculitis is a significant area of ongoing research. Adjunctive treatments are used to reduce cumulative doses of glucocorticoids and therefore may significantly decrease the associated fracture risk in patients with vasculitis. Lastly, we will highlight the many unknowns in the relation between systemic vasculitis, its treatment and bone health and will outline key research priorities for this field.

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“…The etiology and pathogenesis of GIOP are not yet fully explicit, but most studies have found that the occurrence of this disease is significantly associated with an imbalance in bone remodeling [7,8] . When it is disrupted, bone formation is less than bone resorption, which leads to a decrease in bone strength and, ultimately to the onset of the disease.…”

Section: Introductionmentioning

confidence: 99%

Effect of internal heat-type acupuncture on bone remodeling in a glucocorticoid-induced osteoporosis model rabbit by regulating the triplet of OPG-RANKL-RANK

Tian,

Ma,

Lian

et al. 2023

Guidelines and Standards of Chinese Medicine

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Introduction: Internal heat-type acupuncture therapy is a new therapeutic method that integrates acupuncture and heat therapy and effectively reduces local muscle inflammation. It has a good effect on the clinical application of osteoporosis. The purpose of this study was to assess the improvement of glucocorticoid-induced osteoporosis (GIOP) after internal heat-type acupuncture treatment as well as its role in promoting the balance of bone remodeling in the GIOP rabbit model by regulating the triplet of osteoprotegerin(OPG)-receptor activator of nuclear factor-KB ligand (RANKL)-receptor activator of nuclear factor-KB (RANK). Methods: The rabbits were divided into the control, model (GIOP), GIOP+Alendronate, and GIOP+Internal heat-type acupuncture groups, with 8 rabbits in each group. At the end of the treatment, all rabbits were sacrificed. The pathologic changes of lumbar vertebrae were observed by x-ray, the morphology of lumbar trabecular bone was observed by HE staining, and the apoptosis of lumbar vertebrae was detected by Tunel. The protein expressions of OPG, RANKL, and RANK in lumbar vertebrae were detected by immunohistochemistry staining, immunofluorescence staining, and Western blotting. Results: Internal heat-type acupuncture partly prevented osteopenia among GIOP-induced rabbits, improved the morphology of lumbar vertebrae, and inhibited the apoptosis of lumbar vertebrae osteocytes. Moreover, by increasing the protein expression level of OPG and reducing the protein expression of RANKL and RANK, internal heat-type acupuncture effectively promoted the balance of bone remodeling and eventually achieved the treatment of GIOP. Conclusion: Internal heat-type acupuncture therapy may promote the balance of bone remodeling by regulating the triplet of osteoprotegerin-receptor activator of nuclear factor-KB ligand-receptor activator of nuclear factor-KB, thereby treating osteoporosis which was induced by glucocorticoid.

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When to Start and Stop Bone-Protecting Medication for Preventing Glucocorticoid-Induced Osteoporosis

Cited by 17 publications

References 87 publications

The Role of Extracellular Vesicles in Osteoporosis: A Scoping Review

The Role of Extracellular Vesicles in Osteoporosis: A Scoping Review

The Impact of High Dose Glucocorticoids on Bone Health and Fracture Risk in Systemic Vasculitides

Effect of internal heat-type acupuncture on bone remodeling in a glucocorticoid-induced osteoporosis model rabbit by regulating the triplet of OPG-RANKL-RANK

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