When the Cause Is Not Crystal Clear

Forryan, James; Mishra, Vinita; Gibbons, Emily

doi:10.1056/nejmcps1809996

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Cited by 5 publications

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“…Typical settings for this are Crohn's disease, celiac sprue, and pancreatic insufficiency. Ileal resection and Roux-en-Y gastric bypass surgery and treatment with orlistat, a bowel and pancreatic lipase inhibitor, have been complicated by oxalate nephropathy [ 6 – 8 ]. Our patient had no symptoms of malabsorption or intestinal disease.…”

Section: Discussionmentioning

confidence: 99%

Acute Oxalate Nephropathy Caused by Excessive Vegetable Juicing and Concomitant Volume Depletion

Chaudhari

Michaud

Srialluri

et al. 2022

Case Reports in Nephrology

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Acute oxalate nephropathy (AON) induced by high dietary intake of oxalate-rich food is a rare cause of acute kidney injury and end-stage renal disease (ESRD). We describe a 68-year-old man with adequate baseline renal function who developed severe AON and ESRD. Six months earlier, he started a daily oxalate-rich fruit and vegetable juice diet high in spinach, with a calculated daily oxalate dietary intake of 1500 mg, about 10 times a typical diet. Renal biopsy showed extensive tubular oxalate deposits and acute tubular damage; the renal tissue was relatively free of chronic changes such as glomerulosclerosis, tubular atrophy, and interstitial fibrosis. A year later, he remains dialysis dependent.

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Section: Discussionmentioning

confidence: 99%