When should we offer antenatal sequencing for urinary tract malformations? A systematic review, cohort study and meta‐analysis
Sarah Sonner,
Kelly Reilly,
Adrian S. Woolf
et al.
Abstract:ObjectiveDetermine the incremental yield of prenatal exome sequencing (PES) over chromosome microarray (CMA) and/or karyotype for urinary tract malformations (UTMs).MethodA prospective cohort study encompassing data from the English Genomic Medicine Service North Thames Laboratory Hub for fetuses with bilateral echogenic kidneys (BEKs) was combined with data from a systematic review. MEDLINE, EMBASE, Web of Science, MedRxiv and GreyLit were searched from 01/2010‐02/2023 for studies reporting on the yield of PE… Show more
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