When should factorial designs be used for late-phase randomised controlled trials?
Ian R White,
Alexander J Szubert,
Babak Choodari-Oskooei
et al.
Abstract:Background A 2×2 factorial design evaluates two interventions (A versus control and B versus control) by randomising to control, A-only, B-only or both A and B together. Extended factorial designs are also possible (e.g. 3×3 or 2×2×2). Factorial designs often require fewer resources and participants than alternative randomised controlled trials, but they are not widely used. We identified several issues that investigators considering this design need to address, before they use it in a late-phase setting. Meth… Show more
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