When should a mare go for assisted reproduction?

Silva, M.A. Coutinho da

doi:10.1016/j.theriogenology.2008.05.039

Cited by 10 publications

(4 citation statements)

References 17 publications

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“…These differences remained for all follicle sizes and in both CL-bearing and non-CL-bearing ovaries. Significant positive correlations between systemic and intrafollicular concentrations of these steroids were found, as previously reported in cows for P 4 , E 2 and T [18]. Moreover, FF provides a complex and peculiar environment for follicular growth, representing the metabolic and secretory activity of granulosa and thecal cells.…”

Section: Discussionsupporting

confidence: 80%

“…The determination of the morphological characteristics of the ovary and CL in mares was used in recent years for clinical diagnostic practices and the application of assisted reproduction techniques [18]. Although the information on steroids in mares is extensive, it is unknown if the presence of CL in the ovary could modify the composition of steroid hormones in the FF.…”

Section: Introductionmentioning

confidence: 99%

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Can the Presence of Ovarian Corpus Luteum Modify the Hormonal Composition of Follicular Fluid in Mares?

Satué

Fazio

Medica

2020

Animals

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The hypothesis of this study was to investigate if the presence of corpus luteum (CL) in one ovary could modify the hormonal content of follicular fluid (FF) in the follicles. Sixty ovaries were taken after the slaughter of 30 clinically healthy mares. In relation to the sizes, the follicles were classified into three different categories, as small (20–30 mm), medium (31–40 mm) and large (≥41 mm). Blood samples were collected from the jugular vein of mares before their slaughter, and then the FF samplings were extracted from each single follicle. The ovaries that were collected were classified into two groups, according to the presence (CL-bearing) or absence (non-CL-bearing) of CL. The serum and FF samples were analysed for progesterone (P4), oestradiol-17β (E2), testosterone (T), androstenedione (A4) and dehydroepiandrosterone (DHEA). Intrafollicular P4 concentrations in large follicles of CL-bearing groups were lower than for non-CL-bearing ones. Intrafollicular E2 concentrations increased with the increase of the follicle diameter in both groups, CL-bearing and non-CL-bearing. However, in the FF with a large and medium follicle size, E2 concentrations were significantly higher in non-CL-bearing groups than in CL-bearing groups. T and A4 significantly increased in the large and medium follicle sizes when compared to the small follicle sizes in both groups, but higher concentrations in the non-CL-bearing group were obtained. Intrafollicular DHEA significantly decreased with the increase of the follicular diameter in both groups. Steroid hormones in FF dynamically changed, according to the presence or not of CL in the ovary. This study brings new knowledge on the role of the CL in the follicular hormonal composition in mares.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Can the Presence of Ovarian Corpus Luteum Modify the Hormonal Composition of Follicular Fluid in Mares?

Satué

Fazio

Medica

2020

Animals

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“…Notably, embryo transfer is performed in thousands of horses every year worldwide with high success rates, 95 suggesting that the insemination‐induced tolerance that plays a role in pregnancy in some species 96 may be less important in others. Other more advanced techniques such as oocyte transfer, intracytoplasmic sperm injection, and nuclear transfer (cloning) are also successfully used in horse reproduction 97 . These techniques are primarily used to generate genetically desirable offspring, but they can also be useful tools in understanding early reproductive events such as fertilization and conception.…”

Section: Value Of the Horse In The Study Of Pregnancy Immunologymentioning

confidence: 99%

Maternal Immune Responses to Trophoblast: The Contribution of the Horse to Pregnancy Immunology

Noronha

Antczak

2010

American J Rep Immunol

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Citation Noronha LE, Antczak DF. Maternal immune responses to trophoblast: the contribution of the horse to pregnancy immunology. Am J Reprod Immunol 2010 The horse has proven to be a distinctively informative species in the study of pregnancy immunology for several reasons. First, unique aspects of the anatomy and physiology of the equine conceptus facilitate approaches that are not possible in other model organisms, such as non‐surgical recovery of early stage embryos and conceptuses and isolation of pure trophoblast cell populations. Second, pregnant mares make strong cytotoxic antibody responses to paternal major histocompatibility complex class I antigens expressed by the chorionic girdle cells, permitting detailed evaluation of the antigenicity of these invasive trophoblasts and how they affect the maternal immune system. Third, there is abundant evidence for local maternal cellular immune responses to the invading trophoblasts in the pregnant mare. The survival of the equine fetus in the face of strong maternal immune responses highlights the complex immunoregulatory mechanisms that result in materno–fetal tolerance. Finally, the parallels between human and horse trophoblast cell types, their gene expression, and function make the study of equine pregnancy highly relevant to human health. Here, we review the most pertinent aspects of equine reproductive immunology and how studies of the pregnant mare have contributed to our understanding of maternal acceptance of the allogeneic fetus.

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“…). Embryo transfer can be easily performed by practitioners that are proficient in general equine reproductive management with acceptable results (70% of pregnancy rate), being currently exploited in various commercial equine breeding centres (Coutinho da Silva ).…”

Section: Introductionmentioning

confidence: 99%

Influence of Seroreactivity to Leptospira and Reproductive Failures in Recipient Mares of Equine Embryo Transfer Programmes

Pinna

Martins

Souza

et al. 2013

Reprod Domestic Animals

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The aim of this study was to demonstrate that seroreactivity against Leptospira is significantly associated to the reproductive efficiency of recipient mares of an embryo transfer (ET) programme. A serosurvey was conducted from August 2007 to March 2009 in five herds from Rio de Janeiro, Brazil, with high rates of reproductive failure, as early embryonic death (>12%), abortion (>12%) and perinatal death. Detailed information about the losses was obtained from practitioner. A total of 338 recipient mares were tested by microscopic agglutination test, and 226 (66.9%) were seroreactive, mainly against serovars Bratislava and Copenhageni. Seroreactivity could be associated to reproductive failure (p < 0.001), and it was demonstrated that a seroreactive mare is 1.8 times more likely (relative risk - RR) to present reproductive failure than a seronegative one, particularly in relation to early embryonic death (p < 0.0001; RR 8.4) but also to abortions (p < 0.0001; RR 3.5), and to perinatal death (p < 0.05; RR 7.3). Therefore, seroreactivity to Leptospira is associated to reproductive failure in all phases of pregnancy in recipient mares, impairing equine ET programmes.

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When should a mare go for assisted reproduction?

Cited by 10 publications

References 17 publications

Can the Presence of Ovarian Corpus Luteum Modify the Hormonal Composition of Follicular Fluid in Mares?

Can the Presence of Ovarian Corpus Luteum Modify the Hormonal Composition of Follicular Fluid in Mares?

Maternal Immune Responses to Trophoblast: The Contribution of the Horse to Pregnancy Immunology

Influence of Seroreactivity to Leptospira and Reproductive Failures in Recipient Mares of Equine Embryo Transfer Programmes

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