“When sex influences the brain: implications for Alzheimer disease”

Frosch, Matthew P.

doi:10.1007/s00401-018-1931-y

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…It is a key regulator of neutrophil-programmed cell death, expressed in human brain at the level of microglia and macrophages [ 75 ]. In line with our results, genetic variation of SERPINB1 seems to be associated to amyloidosis in a sex-specific manner [ 76 ] and, additionally, its expression in prefrontal cortex has been related to amyloid burden [ 77 ], further supporting the possible involvement of SERPINB1 in neurodegeneration.…”

Section: Discussionsupporting

confidence: 87%

Serpin Signatures in Prion and Alzheimer’s Diseases

et al. 2022

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Serpins represent the most broadly distributed superfamily of proteases inhibitors. They contribute to a variety of physiological functions and any alteration of the serpin-protease equilibrium can lead to severe consequences. SERPINA3 dysregulation has been associated with Alzheimer’s disease (AD) and prion diseases. In this study, we investigated the differential expression of serpin superfamily members in neurodegenerative diseases. SERPIN expression was analyzed in human frontal cortex samples from cases of sporadic Creutzfeldt-Jakob disease (sCJD), patients at early stages of AD–related pathology, and age-matched controls not affected by neurodegenerative disorders. In addition, we studied whether Serpin expression was dysregulated in two animal models of prion disease and AD.Our analysis revealed that, besides the already observed upregulation of SERPINA3 in patients with prion disease and AD, SERPINB1, SERPINB6, SERPING1, SERPINH1, and SERPINI1 were dysregulated in sCJD individuals compared to controls, while only SERPINB1 was upregulated in AD patients. Furthermore, we analyzed whether other serpin members were differentially expressed in prion-infected mice compared to controls and, together with SerpinA3n, SerpinF2 increased levels were observed. Interestingly, SerpinA3n transcript and protein were upregulated in a mouse model of AD. The SERPINA3/SerpinA3nincreased anti-protease activity found in post-mortem brain tissue of AD and prion disease samples suggest its involvement in the neurodegenerative processes. A SERPINA3/SerpinA3n role in neurodegenerative disease-related protein aggregation was further corroborated by in vitro SerpinA3n-dependent prion accumulation changes. Our results indicate SERPINA3/SerpinA3n is a potential therapeutic target for the treatment of prion and prion-like neurodegenerative diseases.

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Section: Discussionsupporting

confidence: 87%

Serpin Signatures in Prion and Alzheimer’s Diseases

et al. 2022

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Observational constraints on the non-flat $$\Lambda CDM$$ model and a null test using the transition redshift

Velasquez-Toribio

Magnago

2020

Eur. Phys. J. C

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A natural extension of the standard cosmological model are models that include curvature as a free parameter. In this work we study in detail the observational constraints on the non-flat C DM model using the two main geometric tests: SNIa and Hubble parameter measurements. In general we show that the observational constraints on the parameters of the C DM model strongly depend on the curvature parameter. In particular, we study the constraints on the transition redshift (z t ) of a universe dominated by matter for a universe dominated by the cosmological constant. Using this observable we construct a new null test defining ζ = z t, f lat − z t,non f lat . This test depends only on the data of the Hubble parameter, the Hubble constant and the matter density parameter. However, it does not depend on derivative of an observable as generally many tests in the literature. To reconstruct this test, we use the Gaussian process method. When we use the best-fit parameters values of P L ANC K /2018, we find no evidence of a disagreement between the data and the standard model (flat C DM), but if we use the value H 0 from R I E SS/2018 we found a disagreement with respect at the standard model. However, it is important to note that the Hubble parameter data has large errors for a solid statistical analysis.

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CSF Biomarkers in Down Syndrome and Autosomal Dominant Alzheimer Disease

Henson

Boerwinkle

et al. 2020

SSRN Journal

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“When sex influences the brain: implications for Alzheimer disease”

Cited by 3 publications

References 7 publications

Serpin Signatures in Prion and Alzheimer’s Diseases

Serpin Signatures in Prion and Alzheimer’s Diseases

Observational constraints on the non-flat $$\Lambda CDM$$ model and a null test using the transition redshift

CSF Biomarkers in Down Syndrome and Autosomal Dominant Alzheimer Disease

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