When RING finger family proteins meet SARS‐CoV‐2

Cai, Chunmei; Tang, Yan-Dong; Zheng, Chunfu

doi:10.1002/jmv.27701

Cited by 8 publications

(11 citation statements)

References 81 publications

(148 reference statements)

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“…Our more recent review has briefly summarized the participation and mechanisms of RNF proteins in SARS-CoV-2 infection for developing novel effective vaccines, diagnoses, and therapies for COVID-19, which is currently the most formidable challenge to humans. 327 However, the roles of other RNF proteins, except TRIMs, have not been fully addressed. Here, we have discussed the current knowledge about the RNF protein’s involvement in regulating the TLR, RLR, cGAS-STING, JAK-STAT pathway, and downstream ISGs.…”

Section: Concluding and Future Perspectivesmentioning

confidence: 99%

The RING finger protein family in health and disease

Cai

Tang

Zhai³

et al. 2022

Sig Transduct Target Ther

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Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) finger (RNF) protein, containing the RING domain, exerts E3 ubiquitin ligase that mediates the covalent attachment of ubiquitin (Ub) to target proteins. Multiple reviews have summarized the critical roles of the tripartite-motif (TRIM) protein family, a subgroup of RNF proteins, in various diseases, including cancer, inflammatory, infectious, and neuropsychiatric disorders. Except for TRIMs, since numerous studies over the past decades have delineated that other RNF proteins also exert widespread involvement in several diseases, their importance should not be underestimated. This review summarizes the potential contribution of dysregulated RNF proteins, except for TRIMs, to the pathogenesis of some diseases, including cancer, autoimmune diseases, and neurodegenerative disorder. Since viral infection is broadly involved in the induction and development of those diseases, this manuscript also highlights the regulatory roles of RNF proteins, excluding TRIMs, in the antiviral immune responses. In addition, we further discuss the potential intervention strategies targeting other RNF proteins for the prevention and therapeutics of those human diseases.

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Section: Concluding and Future Perspectivesmentioning

confidence: 99%

The RING finger protein family in health and disease

Cai

Tang

Zhai³

et al. 2022

Sig Transduct Target Ther

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“…Although the research in the biomedical field has developed rapidly, many emerging infectious diseases such as Zika virus disease, dengue fever, and SARS‐CoV‐2. 107 , 108 , 109 Growing evidence suggests that changes in the 3D genome often accompany the occurrence of diseases. Using 3D genomics to explore alterations in the 3D chromatin structure such as CT, A/B Compartment, TADs, and CL before and after the occurrence of diseases, as well as changes in the interaction between different regulatory elements and target genes, can offer new insights in the pathogenic mechanisms of viral infection.…”

Section: Concluding Remarks and Perspectivesmentioning

confidence: 99%

“…Imaging technology can be developed to visualize the 3D genome directly.Various diseases seriously threaten human health. Although the research in the biomedical field has developed rapidly, many emerging infectious diseases such as Zika virus disease, dengue fever, and SARS-CoV-2 [107][108][109]. Growing evidence suggests that changes in the 3D genome often accompany the occurrence of diseases.…”

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confidence: 99%

When 3D genome technology meets viral infection, including SARS‐CoV‐2

Liang

Wang

Wang³

et al. 2022

Journal of Medical Virology

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Mammalian chromosomes undergo varying degrees of compression to form three‐dimensional genome structures. These three‐dimensional structures undergo dynamic and precise chromatin interactions to achieve precise spatial and temporal regulation of gene expression. Most eukaryotic DNA viruses can invade their genomes into the nucleus. However, it is still poorly understood how the viral genome is precisely positioned after entering the host cell nucleus to find the most suitable location and whether it can specifically interact with the host genome to hijack the host transcriptional factories or even integrate into the host genome to complete its transcription and replication rapidly. Chromosome conformation capture technology can reveal long‐range chromatin interactions between different chromosomal sites in the nucleus, potentially providing a reference for viral DNA‐host chromatin interactions. This review summarized the research progress on the three‐dimensional interaction between virus and host genome and the impact of virus integration into the host genome on gene transcription regulation, aiming to provide new insights into chromatin interaction and viral gene transcription regulation, laying the foundation for the treatment of infectious diseases.

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“…The important roles of really interesting new gene (RING) finger (RNF) proteins as antiviral effector proteins during SARS-CoV-2 infection have already been described ( 10 , 11 ). RNF proteins have a direct antiviral effect by targeting the envelope glycoproteins and genome of SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, some members of the RNF family are strong regulators of the antibody-related neutralization of SARS-CoV-2 and innate antiviral immunity. It should be noted that SARS-CoV-2 can hijack the RNF proteins-associated ubiquitination process and thus avoid the antiviral innate immunity of the host and increase replication of the virus ( 11 , 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%