When NK cells overcome their lack of education

Jaeger, Baptiste N.; Vivier, Éric

doi:10.1172/jci63524

Cited by 14 publications

(11 citation statements)

References 20 publications

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“…30 In this study, ADCC from KIR-positive NK cells was shown to be inhibited by HLA cognate interaction, but this inhibition was reversible by the addition of anti-HLA Abs in vitro, 30 supporting the rationale of blocking KIR to enhance the ADCC effect of therapeutic antibodies. 31 Furthermore, in human patients, lirilumab targets several KIRs-KIR2DL1, -L2, -L3, -S1, and -S2-expressed on half of the total NK-cell population. The inhibitory KIRs targeted by lirilumab collectively recognize virtually all HLA-C alleles, and the blockade of all three KIR2DLs allows treating all patients without prior HLA or KIR typing.…”

Section: Discussionmentioning

confidence: 99%

Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies

Kohrt

Thielens

Marabelle

et al. 2014

Blood

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251

186

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Section: Discussionmentioning

confidence: 99%

Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies

Kohrt

Thielens

Marabelle

et al. 2014

Blood

Self Cite

251

186

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“…32 In light of these observations, functional benefits obtained from education are apparent only when potential targets lack the expression of self-educating ligands. 83, 88 Thus, two roles for inhibitory receptors are shown. First, inhibitory receptors trigger beneficial educational impacts to enable NK cells to sense a missing self.…”

Section: Reversal Of Nk Cell Education In Tumor and Virus Infectionmentioning

confidence: 99%

“…The anti-KIR blocking antibody, for example, relieves educated NK cells from MHC-I-mediated inhibition and provides a promising therapeutic approach for tumor treatment. 88, 89, 90 …”

Section: Reversal Of Nk Cell Education In Tumor and Virus Infectionmentioning

confidence: 99%

NK cell education via nonclassical MHC and non-MHC ligands

2016

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Natural killer (NK) cell education, a process for achieving functional maturation and self-tolerance, has been previously defined by the interaction between self-major histocompatibility complex class I (MHC-I) molecules and their specific inhibitory receptors. Over the past several years, growing evidence has highlighted the important roles of nonclassical MHC-I and non-MHC-I molecules in NK cell education. Herein, we review the current knowledge of NK cell education, with a particular focus on nonclassical MHC-I- and non-MHC-I-dependent education, and compare them with the classical MHC-I-dependent education theory. In addition, we update and extend this theory by presenting the 'Confining Model', discussing cis and trans characteristics, reassessing quantity and quality control, and elucidating the redundancy of NK cell education in tumor and virus infection.

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“…These receptors serve an NK activating (e.g., via monomorphic NKG2D and NKp46 in man and mice, respectively) or inhibitory role (i.e., via family of polymorphic KIRs and Ly49 receptors in man and mice, respectively). By virtue of their MHC class I-specific inhibitory pattern recognition receptors, NK cells are capable of detecting and killing cells that have lost cognate self MHC class I-educating ligands [22,23]. In addition, the expression on target cells of ligands recognised by activating NK receptors (e.g., NKG2D and NKp46) serves as another important checkpoint for NK cell activation and induction of their cytolytic activity and cytokine production [24,25].…”

Section: Nk Cell-based Immunotherapy and Vaccines: The New Holy Grailmentioning

confidence: 99%

Re-thinking Vaccinology: “Act Universally, think NK Cells”?

Bossche¹

2017

Clin Immunol Res

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Traditional and modern vaccines that are currently licensed for commercial use have proven safe and effective in fighting several infectious diseases; they are unquestionably among the most efficient tools for promoting individual, public and global health. However, the vaccine field is still facing important shortcomings in that the use of vaccines has not been successful yet in preventing many other, especially chronic, infectious diseases and that a therapeutic effect remains beyond reach of contemporary vaccines. As vaccine-mediated immune protection is widely acknowledged to result from the combined effect of specific target antigens and nonspecific immune stimulating agents, it is likely that limitations of conventional vaccinal antigens and adjuvants are responsible for these shortcomings.

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When NK cells overcome their lack of education

Cited by 14 publications

References 20 publications

Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies

Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies

NK cell education via nonclassical MHC and non-MHC ligands

Re-thinking Vaccinology: “Act Universally, think NK Cells”?

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