When Myc's asleep, embryonic stem cells are dormant

Abstract

Myc is one of the original reprogramming factors used to produce induced pluripotent stem cells. However, it is not necessary, instead its main role is to increase the efficiency of the reprogramming. The article by Scognamiglio et al () helps clarify how. The authors show that Myc depletion leads to a reversible dormant state consistent with diapause. In this state, the cell sees its proliferation potential diminished but its pluripotency unchanged. The ability to coordinate the induction of this state should have important implications in cell differentiation.

Evaluation of molecular markers in osteogenic differentiation of mesenchymal stem cells

“…Despite the discovery of new sources, markers and use of stem cells, Bone Marrow Mesenchymal Stem Cells (BMSCs) remained the most studied adult stem cells (Friedenstein et al, 1966;Kadiyala et al, 1997;Nakagawa et al, 2016;Rada et al, 2011;Seong et al, 2010). BMSCs and other stem cell sources have been used in clinical trials specifically to skeletal regeneration and bone tissue engineering as exemplified in (Bianco et al, 2013).…”