“…Appraising the quality of the evidence is a crucial part of evidence synthesis, as low-quality studies could misinform further studies or create diverging opinions among stakeholders. [14][15][16] In our empirical example presented in online supplemental materials, we show how our approach was used in the evaluation of sentinel lymph node biopsy for the management of oral cavity squamous cell carcinoma. The evaluation process took off with an evidence synthesis of international guidelines.…”