A restoration project is planned to take place in the northern Venice lagoon (northern Adriatic Sea, Italy), aiming at introducing freshwater into a confined shallow water lagoon area and recreating transitional water habitats. This work describes the shifts in the nekton (fish and decapods) community structure to be expected following the future salinity decrease in the restoration area. Nekton was sampled at a series of natural shallow water sites located along salinity gradients in the Venice lagoon. A multivariate GLM approach was followed in order to predict species biomass under the salinity and environmental conditions expected after restoration. Biomass of commercially important species, as well as species of conservation interest, is predicted to increase following salinity reduction and habitat changes. From a functional perspective, an increase in biomass of hyperbenthivores-zooplanctivores, hyperbenthivores-piscivores and detritivores is also expected. This study emphasises the efficacy of a predictive approach for both ecological restoration and ecosystem management in transitional waters. By providing scenarios of community structure, the outcomes of this work could be employed in future evaluations of restoration success in the Venice lagoon, as well as to develop management tools to forecast the effects of alterations of salinity regimes in coastal lagoons due to climate change.