When histones are under glucose starvation

Lee, Jaehyoun; Oh, Shi-Hwan; Abmayr, Susan M.; Workman, Jerry L.

doi:10.1007/s12038-019-9971-6

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Furthermore, epigenetic modifications have various protective roles during starvation [45,46]. Under nutritional stress, several histone marks have been reported that may act as switches upon starvation for stress-response pathways [47]. We observed upregulated histone acetylation under prolonged starvation in both organs, which has also been reported in the regulation of autophagy [48].…”

Section: Autophagy At the Core Of Regulatory Pathwayssupporting

confidence: 72%

Temporal and Spatial Signatures of Scylla paramamosain Transcriptome Reveal Mechanistic Insights into Endogenous Ovarian Maturation under Risk of Starvation

Fu,

Zhang,

Wang

et al. 2024

IJMS

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Variability in food availability leads to condition-dependent investments in reproduction. This study is aimed at understanding the metabolic response and regulatory mechanism of female Scylla paramamosain in response to starvation in a temporal- and tissue-specific manner. The mud crabs were starved for 7 (control), 14, 28, and 40 days for histological and biochemical analysis in the hepatopancreas, ovary, and serum, as well as for RNA sequencing on the hepatopancreas and ovary. We further highlighted candidate gene modules highly linked to physiological traits. Collectively, our observations suggested that starvation triggered endogenous ovarian maturation at the expense of hepatopancreas mass, with both metabolic adjustments to optimize energy and fatty acid supply from hepatopancreas to ovary in the early phase, followed by the activation of autophagy-related pathways in both organs over prolonged starvation. These specific adaptive responses might be considered efficient strategies to stimulate ovarian maturation of Scylla paramamosain under fasting stress, which improves the nutritional value of female mud crabs and other economically important crustaceans.

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Section: Autophagy At the Core Of Regulatory Pathwayssupporting

confidence: 72%

Temporal and Spatial Signatures of Scylla paramamosain Transcriptome Reveal Mechanistic Insights into Endogenous Ovarian Maturation under Risk of Starvation

Fu,

Zhang,

Wang

et al. 2024

IJMS

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“…AMPK also has a central role in regulating nutritional stress-specific chromatin modification ( Lee et al, 2020 ). In yeast, Snf1 is required for H3 serine 10 phosphorylation (H3pS10) at the INO1 gene promoter to regulate its transcription ( Lo et al, 2001 ).…”

Section: Introductionmentioning

confidence: 99%

Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress by the cooperation of AMPK and CK2 signaling

Lee

Swanson

et al. 2020

eLife

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Changes in available nutrients are inevitable events for most living organisms. Upon nutritional stress, several signaling pathways cooperate to change the transcription program through chromatin regulation to rewire cellular metabolism. In budding yeast, histone H3 threonine 11 phosphorylation (H3pT11) acts as a marker of low glucose stress and regulates the transcription of nutritional stress-responsive genes. Understanding how this histone modification ‘senses’ external glucose changes remains elusive. Here, we show that Tda1, the yeast ortholog of human Nuak1, is a direct kinase for H3pT11 upon low glucose stress. Yeast AMP-activated protein kinase (AMPK) directly phosphorylates Tda1 to govern Tda1 activity, while CK2 regulates Tda1 nuclear localization. Collectively, AMPK and CK2 signaling converge on histone kinase Tda1 to link external low glucose stress to chromatin regulation.

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“…AMPK also has a central role in regulating nutritional stress-specific chromatin modification (Lee, Oh, Abmayr, & Workman, 2020). In yeast, Snf1 phosphorylates H3 at serine 10 at the INO1 gene promoter to regulate its transcription (Lo et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress conditions by the cooperation of AMPK and CK2 signaling

Lee

Swanson

et al. 2020

Preprint

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Changes in available nutrients are inevitable events for most living organisms. Upon nutritional stress, several signaling pathways cooperate to change the transcription program through chromatin regulation to rewire cellular metabolism. In budding yeast, histone H3 threonine 11 phosphorylation (H3pT11) acts as a marker of low glucose stress and regulates the transcription of nutritional stress responsive genes. Understanding how this histone modification senses external glucose changes remains elusive. Here, we show that Tda1, the yeast orthologue of human Nuak1, is a direct kinase for H3pT11 upon low glucose stress. Yeast AMPK directly phosphorylates Tda1 to govern Tda1 activity, while CK2 regulates Tda1 nuclear localization. Collectively, AMPK and CK2 signaling converge on histone kinase Tda1 to link external low glucose stress to chromatin regulation.

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When histones are under glucose starvation

Cited by 3 publications

References 23 publications

Temporal and Spatial Signatures of Scylla paramamosain Transcriptome Reveal Mechanistic Insights into Endogenous Ovarian Maturation under Risk of Starvation

Temporal and Spatial Signatures of Scylla paramamosain Transcriptome Reveal Mechanistic Insights into Endogenous Ovarian Maturation under Risk of Starvation

Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress by the cooperation of AMPK and CK2 signaling

Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress conditions by the cooperation of AMPK and CK2 signaling

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