When high is low: Raising low levels of high-density lipoprotein cholesterol

Tóth, Peter P.

doi:10.1007/s11886-008-0077-2

Cited by 12 publications

(5 citation statements)

References 71 publications

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“…25,[27][28][29][30][31][32][33][34] Thus, the analyses presented are limited to C-reactive protein (CRP), hemoglobin A1C (hgA1C), and high-density lipoprotein (HDL) cholesterol.…”

Section: Blood Specimen Collection and Assaysmentioning

confidence: 99%

Neighborhood Socioeconomic Status in Relation to Serum Biomarkers in the Black Women’s Health Study

et al. 2016

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Lower neighborhood socioeconomic status (SES) is associated with higher cardiovascular disease (CVD) risk. Black women have a higher CVD risk and are more likely to live in poor neighborhoods than white women. We examined the association of neighborhood SES with several CVD biomarkers using data from the Black Women's Health Study (BWHS), a follow-up study of US black women reporting high levels of education and income. Blood specimens of 418 BWHS participants were assayed for Creactive protein (CRP), hemoglobin A1C (hgA1C), and high-density lipoprotein (HDL) cholesterol. US Census block group data were linked to the women's addresses to reflect neighborhood SES. Multivariable-adjusted mixed linear regression models that adjusted for person-level SES and for cardiovascular risk factors were used to assess CRP, hgA1C, and HDL levels in relation to quintiles of neighborhood SES. Women living in the poorest neighborhoods had the least favorable biomarker levels. As neighborhood SES increased, CRP decreased (P for trend = 0.01), hgA1C decreased (P for trend = 0.07), and HDL increased (P for trend = 0.19). These associations were present within strata of individual educational level. The present findings suggest that neighborhood environments may affect physiological processes within residents independently of individual SES.

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“…25,[27][28][29][30][31][32][33][34] Thus, the analyses presented are limited to C-reactive protein (CRP), hemoglobin A1C (hgA1C), and high-density lipoprotein (HDL) cholesterol.…”

Section: Blood Specimen Collection and Assaysmentioning

confidence: 99%

Neighborhood Socioeconomic Status in Relation to Serum Biomarkers in the Black Women’s Health Study

et al. 2016

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“…Total cholesterol (TC) is composed of 3 main types of lipoproteins—low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very-low-density lipoprotein (VLDL) [4,5]. The association between elevated LDL cholesterol (LDL-C) and increased risk for cardiovascular events is well established [6], and other lipid parameters are also predictive of cardiovascular risk, including high non-HDL [4], low HDL [7], and elevated triglyceride (TG) levels [8]. …”

Section: Introductionmentioning

confidence: 99%

Total cholesterol and lipoprotein composition are associated with dry eye disease in Korean women

et al. 2013

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BackgroundThis study aimed to determine the relationship between dyslipidemia and dry eye disease (DED) in a Korean population.MethodsThis population-based study enrolled 5,627 adults (aged >19 years) who were participating in the first year of the fifth annual Korea National Health and Nutrition Examination Survey from 2010 to 2011. Clinically diagnosed DED and its symptoms were surveyed, and biochemical blood analysis data were collected. Dyslipidemia was defined as any of the following: hypercholesterolemia (total cholesterol > 200 mg/dL), hypertriglyceridemia (triglyceride > 150 mg/dL), low levels of high-density lipoprotein (<40 mg/dL), or high levels of low-density lipoprotein (>100 mg/dL).ResultsAfter adjusting for demographics (age and body mass index), lifestyle (smoking, drinking, exercise, and residential district), and medical factors (diabetes, hypertension, previous ophthalmic surgery, menopause, and rheumatologic disease), elevated serum cholesterol level was found to be associated with increased likelihood of DED (odds ratio, 1.77; 95% confidence interval, 1.127–2.78) in women.ConclusionsDED in a Korean population was found to be associated with high serum cholesterol levelsThe results of this study highlight the significance of eye examinations and independent lipid profile monitoring in patients with dyslipidemia because of its possible correlation with DED progression.

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“…33 HDL particles are widely believed to be atheroprotective because of their capacity to drive reverse cholesterol transport, normalize endothelial dysfunction, and inhibit oxidation, inflammation, insulin resistance, and thrombosis. 34 Hence, the decline in HDL-C with lung transplantation could indicate an increase in cardiovascular risk. Studies in other populations have consistently demonstrated an increased risk for cardiovascular events on the order of 2e3% per 1 mg/dL reduction in HDL-C. 35 While the magnitude of the risk attributable to the lipid changes observed in patients undergoing lung transplantation remains unclear, the median decline in HDL-C of 25 mg/dL is substantial, and cardiovascular mortality remains a major contributor to death following lung transplantation, accounting for nearly 11% of deaths within the first 30 days of transplantation.…”

Section: Discussionmentioning

confidence: 99%