When high-fat diet plus hypertension does not equal vascular dysfunction

Jones‐Muhammad, Maria; Warrington, Junie P.

doi:10.1152/ajpheart.00284.2021

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…The statin class of drugs is frequently used to decrease cholesterol levels. Statins are predicted to lower LDL cholesterol, raise HDL cholesterol, and lower triglycerides without causing significant adverse effects [12].…”

Section: Introductionmentioning

confidence: 99%

“…Hibiscus sabdariffa. L (HSL), also known as red sorrel or roselle, belongs to the Malvaceae family and has been used as a medicinal herb in Africa, Asia, and Latin America to treat hypertension, urinary bladder, and kidney stones, as a diuretic, and to treat liver problems [12]. The antioxidant properties of HSL calyxes, shown by gossypetin, anthocyanins, hibiscus glycosides, and other flavonoid Meanwhile, in vitro studies show anthocyanins can stimulate insulin release [14].…”

Section: Introductionmentioning

confidence: 99%

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Roselle Calyx (Hibiscus Sabdariffa. L) as an Anti-Diabetic: Ethyl Acetate Fraction Reduce Fasting Blood Glucose Total Cholesterol and Repair Pancreas Function on Diabetic Model

SUHARTI,

ARMENIA,

ABDILLAH

et al. 2024

Int J App Pharm

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Objective: In general, people with diabetes mellitus will experience disturbances in fat metabolism that lead to hypercholesterolemia. This study aims to determine the effect of ethyl acetate fraction hibiscus calyx on blood sugar, blood cholesterol level, and pancreas histology in diabetic Wistar Kyoto rats induced by streptozotocin. Methods: Thirty-six Wistar Kyoto rats were induced with intra-peritoneal streptozotocin at 55 mg/kg BW and stabilized for five days to obtain diabetic conditions. Diabetic animals were divided into four groups; the diabetic group was given vehicle, the glibenclamide group was given 0.45 mg/kg BW of Glibenclamide, and two groups were administered the ethyl acetate fraction of hibiscus calyxes (EAFHC) at doses of 100 mg/kg BW and 200 mg/kg BW for five days. Fasting blood sugar and lipids (total cholesterol and triglycerides) were measured on days 0, 1, 3, and 5. Pancreats were collected on days 1, 3 and 5 for weighing and histology examination. All data were analyzed using two-way ANOVA followed by the Duncan Multiple Rank Test (DMRT). Results: EAFHC significantly reduced fasting blood sugar and total cholesterol (p<0.05) but did not have a significant effect on triglycerides (p>0.05). Histology examination showed that EAFHC repaired pancreatic damage, as seen from the decrease in pancreatic histology scores (p<0.05), but the organ ratio did not show a significant improvement (p>0.1). Conclusion: This study revealed that EAFHC could be an alternative medicine in managing blood sugar levels and total cholesterol and improving pancreas function in associated models of diabetes mellitus hypercholesterolemia complications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Roselle Calyx (Hibiscus Sabdariffa. L) as an Anti-Diabetic: Ethyl Acetate Fraction Reduce Fasting Blood Glucose Total Cholesterol and Repair Pancreas Function on Diabetic Model

SUHARTI,

ARMENIA,

ABDILLAH

et al. 2024

Int J App Pharm

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Vascular endothelial adiponectin signaling across the life span

Cohen

Katunaric

SenthilKumar

et al. 2022

American Journal of Physiology-Heart and Circulatory Physiology

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Cardiovascular disease risk increases with age regardless of sex. Some of this risk is attributable to changes in natural hormones throughout the lifespan. The quintessential example of this being the dramatic increase in cardiovascular disease following the transition to menopause. Plasma levels of adiponectin, a "cardioprotective" adipokine released primarily by adipose tissue and regulated by hormones, also fluctuates throughout one's life. Plasma adiponectin levels increase with age in both men and women, with higher levels in both pre- and post- menopausal women compared to men. Younger cohorts seem to confer cardioprotective benefits from increased adiponectin levels yet elevated levels in the elderly and those with existing heart disease are associated with poor cardiovascular outcomes. Here, we review the most recent data regarding adiponectin signaling in the vasculature, highlight the differences observed between the sexes, and shed light on the apparent paradox regarding increased cardiovascular disease risk despite rising plasma adiponectin levels over time.

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When high-fat diet plus hypertension does not equal vascular dysfunction

Cited by 2 publications

References 9 publications

Roselle Calyx (Hibiscus Sabdariffa. L) as an Anti-Diabetic: Ethyl Acetate Fraction Reduce Fasting Blood Glucose Total Cholesterol and Repair Pancreas Function on Diabetic Model

Roselle Calyx (Hibiscus Sabdariffa. L) as an Anti-Diabetic: Ethyl Acetate Fraction Reduce Fasting Blood Glucose Total Cholesterol and Repair Pancreas Function on Diabetic Model

Vascular endothelial adiponectin signaling across the life span

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