When Heparins Promote Thrombosis

Jang, Ik‐Kyung; Hursting, Marcie J.

doi:10.1161/circulationaha.104.518563

Cited by 215 publications

(87 citation statements)

References 102 publications

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“…This is reported in 4.8% of post-orthopedic surgical patients treated with unfractionated heparin and 0.6% treated with low molecular weight heparins [3]. Platelet count drop of at least 50% starting from 5 to 10 days after heparin initiation is suggestive of the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Bilateral adrenal hemorrhage associated with heparin induced thrombocytopenia

Kurtz

Yang

2007

American J Hematol

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Heparin induced thrombocytopenia (HIT) is associated with serious and sometimes devastating thrombotic events. We report a case of bilateral adrenal hemorrhage (BAH) associated with HIT after prophylactic use of low molecular weight heparin. The vague presenting symptoms of acute adrenal insufficiency offers a diagnostic challenge, which if delayed may be life threatening. A high index of suspicion for adrenal hemorrhage is required in patients receiving any form of heparin therapy presenting with new onset thrombocytopenia, abdominal pain, and fevers. Am. J. Hematol. 82:493-494, 2007. V V C 2007 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Bilateral adrenal hemorrhage associated with heparin induced thrombocytopenia

Kurtz

Yang

2007

American J Hematol

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“…HITTSheparin-induced thrombocytopenia with thrombosis syndrome) (1)(2)(3)(4)(5)(6). Tai svarbi patologija, nes heparinas tapo vienu iš dažniausiai vartojamų vaistų pasaulyje ir indikacijos heparino vartojimui plečiasi (7,8).…”

Section: Tęstinės Medicinos Studijosunclassified

“…(1,2,7,8,11,13). Dažnį sunku įvertinti, nes jis priklauso nuo vartoto heparino tipo, dozės, gydymo trukmės, klinikinės būklės.…”

Section: Etiologija Dažnisunclassified

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Heparin-induced thrombocytopenia

Reingardienė

2008

Medicina

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“…HIT is around 10 fold less common with low molecular weight heparin preparations (LMWH) than with unfractionated heparin (UFH) [4]. Heparin is a drug widely used for thromboprophylaxis or treatment in many clinical conditions, including cardiovascular surgery and invasive procedures, acute coronary syndromes, venous thromboembolism, atrial fibrillation, peripheral occlusive disease, dialysis and during extracorporeal circulation [5,6]. Unfortunately, it can cause serious adverse effects, such as HIT which is a common, serious and potentially life-threatening condition [2,[7][8][9].…”

Section: Introductionmentioning

confidence: 99%

The Incidence of Heparin Induced Thrombocytopenia in Orthopedic Surgery Patients in Khartoum, Sudan

2017

IJCRR

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Aim: The aim of this study was to determine the incidence of low molecular weight heparin (LMWH) induced thrombocytopenia in patients undergoing orthopedic surgery in Khartoum Teaching Hospital. Heparin induced thrombocytopenia (HIT) is a complication of heparin therapy in which the platelet count falls by 50% or more of the baseline value, or falls to below 150×10 9 /L.Methodology: This is a prospective cross sectional study carried out in Khartoum Teaching Hospital, Department of Orthopedic Surgery in the period between April-July 2013.Results: Seventy three patients were included, forty nine (67.1%) were males and 24 (32.9%) were females. Most of the patients were between 40-59 years of age (50.7%). Sixty nine (94.52%) of the patients were not exposed to heparin before. All patients received LMWH as prophylaxis except 2 patients who received it for treatment. Fifty patients (68.49%) received LMWH in a dose of 3500 (IU) per day while 23 patients (31.51%) received it in a dose of 4500 IU. Fifty six of the patients received LMWH for 2 weeks, 15 patients for less than 2 weeks while 2 patients for more than 2 weeks. All patients had a baseline platelet count equal or more than 150×10 9 /L. On day 14, none of the patients had 50% reduction or more in the platelet count from the baseline or a platelet count of less than 150×10 9 /L. Conclusion:The study found that no patient treated with LMWH had significant HIT.

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When Heparins Promote Thrombosis

Cited by 215 publications

References 102 publications

Bilateral adrenal hemorrhage associated with heparin induced thrombocytopenia

Bilateral adrenal hemorrhage associated with heparin induced thrombocytopenia

Heparin-induced thrombocytopenia

The Incidence of Heparin Induced Thrombocytopenia in Orthopedic Surgery Patients in Khartoum, Sudan

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