When does simple heartburn become a diseases?

Shaw, M. P. Chandie; Adlis, SA; Beebe, TJ; Clinic, Park Nicollet; Mn, Minneapolis; Talley, NJ

doi:10.1016/s0016-5085(98)81156-6

Cited by 12 publications

(9 citation statements)

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“…ASTROESOPHAGEAL reflux disease (GERD) is a ubiquitous, chronic disorder that may cause a significant decrease in patient functioning and quality of life and an increase in the risk for esophageal damage. While a large percentage of individuals report occasional or monthly heartburn, 1 approximately 20% of the US adult population experiences reflux symptoms on a weekly basis. 2 A recent study found that the presence of weekly heartburn symptoms has a significant negative impact on patients' physical and mental functioning.…”

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confidence: 99%

Lansoprazole Compared With Ranitidine for the Treatment of Nonerosive Gastroesophageal Reflux Disease

et al. 2000

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Lansoprazole Compared With Ranitidine for the Treatment of Nonerosive Gastroesophageal Reflux Disease

et al. 2000

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“…Gastroesophageal reflux disease in pregnancy presents a special challenge for the clinician and is not uncommon in pregnancy, occurring in approximately 45% to 80% of pregnant women. 2,3 The reported prevalence of heartburn and/or acid regurgitation among western pregnant women is 48-96% and 62%, respectively. 10,11 Hey et al 12 in a pH study in pregnant women with and without GER found that reflux in pregnancy could be largely asymptomatic, and what is seen in day-to-day practice may just be the tip of the iceberg.…”

Section: Discussionmentioning

confidence: 99%

Gastroesophageal reflux disease in pregnancy: a longitudinal study

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2014

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Background: Gastroesophageal reflux (GER) symptoms are common in pregnancy. It often manifests for the first time in pregnancy during the first three months and ceases after delivery.Aim: To study the prevalence of gastroesophageal reflux in each of the three trimesters by follow-up of pregnant women. To examine the association between dietary factors and GER in pregnancy Methods: This was a prospective hospital-based study. Sixty four pregnant women in their first trimester attending an antenatal clinic were interviewed for symptoms of GER and for dietary details and followed up until term and delivery.Results: Fifty women (83.4%) experienced either heartburn or regurgitation during pregnancy. GER was commoner in primi-gravida (69.3%) and 50% remained symptomatic until term.Regurgitation was more common than heartburn and was often associated with nausea / vomiting. Women with an antenatal history of GERD had 3.79 times the odds of developing symptoms in the third trimester. There was no difference in weight gain in those with and without GER. Spicy food significantly increased the risk of heartburn and green vegetables were protective. Conclusions: The incidence of GERD decreased over three trimesters. Weight gain did not increase the prevalence of GERD. Spicy food aggravated while green vegetables protected against GERD.KEYWORDS: gastroesophageal reflux disease, pregnancy, diet the first three months of gestation and ceases soon after delivery. 7,8 The origin of GER in pregnancy is multifactorial, but the predominant factor is a decrease in lower esophageal sphincter pressure caused by progesterone. Mechanical factors play a minor role. Serious reflux complications during pregnancy are rare and seldom do these patients need investigation.Our recent cross sectional study found a prevalence of 45.5% GER in pregnancy. 9 There however has been no prospective study from India examining the natural history of

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“…Of all respondents, 7.8% consulted a physician about their complaints. 3 Another postal survey, of 2200 randomly selected residents of Olmstead County, Minnesota, revealed that approximately 20% experienced at least one weekly episode, and 60% experienced occasional episodes of GERD symptoms. Prevalence was similar across all age groups studies (25-74 years), with no significant difference between men and women.…”

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confidence: 99%

Heartburn in primary care: problems below the surface

2004

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Heartburn is a common physiological event often associated with an underlying occurrence of gastroesophageal reflux disease (GERD). Studies show that GERD is a highly prevalent and chronic condition that significantly impacts on the patient's quality of life (QoL) and, in the long term, increases the risk for developing esophageal adenocarcinoma, more commonly referred to as Barrett's esophagus. Data indicate that symptom severity is a poor predictor of either the presence of erosive mucosal lesions or the development of complications. Given that lifestyle modifications are often insufficient for long-term treatment of GERD, drugs that inhibit gastric acid production--such as the proton pump inhibitors (PPIs)--are now the most effective strategy. Although generally well tolerated, the potential of PPIs for interactions with other drugs needs to be considered. This review discusses the symptoms and risk factors associated with GERD, possible links to Helicobacter pylori infection, and effective treatment strategies within a primary care setting.

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When does simple heartburn become a diseases?

Cited by 12 publications

References 0 publications

Lansoprazole Compared With Ranitidine for the Treatment of Nonerosive Gastroesophageal Reflux Disease

Lansoprazole Compared With Ranitidine for the Treatment of Nonerosive Gastroesophageal Reflux Disease

Gastroesophageal reflux disease in pregnancy: a longitudinal study

Heartburn in primary care: problems below the surface

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