When do the symptoms of autonomic nervous system malfunction appear in patients with Parkinson’s disease?

Luka, Silvio R. De; Svetel, Marina; Pekmezovic, T.; Milovanovic, Branislav; Vs, Kostić

doi:10.2298/vsp1404346d

Cited by 11 publications

(3 citation statements)

References 32 publications

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“…The role of central noradrenergic dysregulation may play a role in both dysautonomia and anxiety [ 55 ]. Additionally, autonomic failure may create a pathophysiological predisposition towards the somatic symptoms of anxiety or a stronger physical response to anxiety in PD, as reported in previous research [ 56 ]. Subjects with higher RBD-HK scores was a risk factor for anxiety in PD in the study, which is in line with previous studies [ 35 , 57 ].…”

Section: Discussionmentioning

confidence: 82%

Prevalence and risk factors for depression and anxiety in Chinese patients with Parkinson disease

Cui

et al. 2017

BMC Geriatr

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Background: Anxiety and depression are common in Parkinson disease and both are important determinants of quality of life in patients. Several risk factors are identified but few research have investigated general and Parkinson's disease (PD)-specific factors comprehensively. The aim of this work was to explore PD-specific and -non-specific risk factors for PD with depression or anxiety. Methods: A cross-sectional survey was performed in 403 patients with PD. Multivariate logistic analysis was used to investigate the prevalence and risk factors for the depression and anxiety in PD. The data of patients included demographic information, medicine history, disease duration, age at onset (AAO), family history, anti-parkinsonism drug, modified Hoehn and Yahr staging (H-Y) stage, scales of motor and non-motor symptoms and substantia nigra (SN) echogenic areas. Results: 403 PD patients were recruited in the study. Depression and anxiety were present in 11.17% and 25.81% respectively. Marital status, tumor, higher Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) II score, dyskinesia, higher Hamilton Anxiety Rating Scale (HARS) score and lower the Parkinson's disease sleep scale (PDSS) score were associated with depression in PD. female gender, higher rapid eye movement behavior disorder Questionnaire-Hong Kong (RBD-HK) score, higher Hamilton Deprssion Rating Scale (HAMD) score, higher the scale for outcomes in PD for autonomic symptoms (SCOPA-AUT)score and larger SN echogenic areas were associated with anxiety. Neither depression nor anxiety was related to any anti-parkinsonism drugs. Conclusions: The prevalence of depression and anxiety in the current PD patients was 11.17% and 25.81% respectively. Disease of tumor, currently having no partner, severer motor function, dyskinesia, poorer sleep quality and anxiety were risk factors for PD with depression. Female, depression, rapid eye movement behavior disorder (RBD), autonomic dysfunction and larger SN area were risk factors for PD with anxiety.

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Section: Discussionmentioning

confidence: 82%

Prevalence and risk factors for depression and anxiety in Chinese patients with Parkinson disease

Cui

et al. 2017

BMC Geriatr

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“…Although the majority of the studies assessing cardiovascular reflexes such as the Ewing’s battery of autonomic tests, showed that parasympathetic dysfunction may be present early in the disease course, 22–24,27–29,32,33 some studies have shown that DNPD manifested only sympathetic dysfunction, either assessing cardiovascular reflexes or on the basis of cardiac radioiodinated metaiodobenzylguanidine uptake. 34 …”

Section: Resultsmentioning

confidence: 99%

The range and nature of non-motor symptoms in drug-naive Parkinson’s disease patients: a state-of-the-art systematic review

Zis

Erro

Walton

et al. 2015

npj Parkinson's Disease

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Non-motor symptoms (NMS) are a key component of Parkinson’s disease (PD). A range of NMS, most notably impaired sense of smell, sleep dysfunction, and dysautonomia are present from the ‘pre-motor’ phase to the final palliative stage. Theories as to the pathogenesis of PD such as those proposed by Braak and others also support the occurrence of NMS in PD years before motor symptoms start. However, research addressing the range and nature of NMS in PD has been confounded by the fact that many NMS arise as part of drug-related side effects. Thus, drug-naive PD (DNPD) patients provide an ideal population to study the differences in the presentation of NMS. The aim of this paper is therefore to systematically review all the available studies of NMS in DNPD patients. We believe this is the first review of its kind. The current review confirms the increasing research being conducted into NMS in DNPD patients as well as the necessity for further investigation into less-studied NMS, such as pain. Moreover, the data confirms non-motor heterogeneity among PD patients, and, therefore, further research into the concept of non-motor subtyping is encouraged. The review suggests that the clinical assessment of NMS should be integral to any assessment of PD in clinical and research settings.

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“…È õîòÿ â ëèòåðàòóðå äîñòàòî÷íî óñòîé-÷èâûì ñ÷èòàåòñÿ îïðåäåëåíèå ÁÏ êàê íåéðîäåãåíåðàòèâíîãî çàáîëåâàíèÿ öåíòðàëüíîé íåðâíîé ñèñòåìû, äîñòàòî÷íî èíòåðåñíî ðàññìîòðåòü âîçìîaeíîñòü òîãî, ÷òî ïðîöåññ íà ñàìîì äåëå íà÷èíàåòñÿ â ïåðèôåðè÷åñêîé íåðâíîé ñèñòåìå. Òàê, òåëüöà è íåéðèòû Ëåâè íàéäåíû â çâåçä÷àòûõ ãàíãëèÿõ è ñåðäå÷íîì ñèìïàòè÷åñêîì ñïëåòåíèè, ïó÷êå Àóýðáàõà è ìîçãîâîì âåùåñòâå íàäïî÷å÷íèêîâ â îòñóòñòâèè ïàòîëîãèè öåíòðàëüíîé íåðâíîé ñèñòåìû [31,32]. Íåäàâíî àãðåãàòû α-ñèíóêëåèíà áûëè îáíàðóaeåíû òàêaeå â âåãåòàòèâíûõ ñïëåòåíèÿõ áðþøíîé ïîëîñòè è ïóçûðüêàõ ïðîñòàòû ïðè ïðîâåäåíèè õèðóðãè÷åñêèõ îïåðàöèé ó çäîðîâûõ ëèö áåç íåâðîëîãè÷åñêîé ïàòîëîãèè (ó îäíîãî èç êîòîðûõ áûëè âûÿâëåíû ðàññòðîéñòâà ïîâåäåíèÿ â REM-ôàçå ñíà) [4,33].…”

Section: классификации немоторных проявлений болезни паркинсонаunclassified

Clinical and pathophysiological aspects of non-motor manifestations of Parkinson's disease

et al. 2020

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Non-motor symptoms are an essential manifestation of the clinical picture of Parkinson's disease (PD). This literature review is devoted to the study of recent advances in the field of clinical and pathophysiological aspects of the non-motor manifestations of Parkinson's disease.Aim. The aim was to study and generalize the wide range of non-motor manifestations of PD and their features in this pathology, and to reveal the pathophysiological link between motor and non-motor manifestations of the disease and the role of the neurodegenerative process in the clinical picture of PD.Materials and methods. Keywords (Parkinson's disease, non-motor symptoms, apathy, anxiety, depression, sleep disorder, pain) search in the Web of Science, Core Collection, Scopus, Pubmed databases.Results. Knowledge about the presence of PD non-motor symptoms, characteristics of their manifestations improve their diagnosis and help to choose the correct treatment strategy. This survey comprises nonmotor manifestations of PD, such as: mood disorders (apathy, anxiety, depression), impulse control disorders (dopamine disregulation syndrome), sleep disorders (insomnia, excessive daytime sleepiness, bouts of sleepiness, conduct disorder in REM phase of sleep), autonomic disorders (constipation, enuresis, thermoregulatory dysfunction, cardiovascular disorders, orthostatic hypotension), and cognitive impairment.

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When do the symptoms of autonomic nervous system malfunction appear in patients with Parkinson’s disease?

Cited by 11 publications

References 32 publications

Prevalence and risk factors for depression and anxiety in Chinese patients with Parkinson disease

Prevalence and risk factors for depression and anxiety in Chinese patients with Parkinson disease

The range and nature of non-motor symptoms in drug-naive Parkinson’s disease patients: a state-of-the-art systematic review

Clinical and pathophysiological aspects of non-motor manifestations of Parkinson's disease

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