When Did They Start? Age of Onset of Toileting Behaviors and Urinary Cues as Reported by Older Women

O’Connell, Kathleen A.; Newman, Diane K.; Palmer, Mary H.

doi:10.1089/whr.2023.0022

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…It showed that behaviors like place preference and delayed voiding start early, often before age 20, while symptoms such as urinary urgency and straining to urinate typically appear after age 45. 44 In terms of diagnostic and therapeutic implications, OAB profiling linked with transition periods plays a pivotal role. A personalized treatment approach has recently been proposed 4 based on several identified pathophysiological phenotypes of OAB shifting the paradigm of universal treatment based only on the degree of invasiveness.…”

Section: Delphi Domainsmentioning

confidence: 99%

Exploring lifelong overactive bladder: Transitions, evidence, and clinical implications; A modified Delphi process

Bou Kheir,

Verbakel,

Vande Walle

et al. 2024

Neurourology and Urodynamics

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IntroductionOveractive bladder (OAB) is a prevalent urological condition characterized by urinary urgency, with or without urgency urinary incontinence, accompanied by increased daytime frequency and nocturia. However, the current definition of OAB lacks a specified time frame, hindering our understanding of the temporal aspects and transitions that occur within the OAB spectrum.MethodsA modified Delphi study was conducted in three rounds, involving a panel of international experts in functional urology, urogynaecology, geriatrics, transitional medicine, and pediatric urology. The study took place between February 2023 and June 2023 and employed two sequential rounds of online surveys, followed by a final hybrid group discussion session in June 2023.ResultsThe Delphi process resulted in a consensus definition of lifelong OAB as a persistent and continuous condition that may manifest differently from birth and evolve over time, with varying levels of clinical perception. The course of its progression is influenced by transition periods and modifying factors, mainly anatomical, hormonal, and psychosocial/stressors. Three main transition periods were identified: achievement of daytime continence, adulthood to elderly, and transition to frail elderly. The panel also considered the therapeutic and diagnostic implications of lifelong OAB, as well as future research prospects in terms of importance and feasibility.ConclusionsFuture longitudinal research is needed to develop this concept and further identify transitions and temporal dynamics.

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Section: Delphi Domainsmentioning

confidence: 99%

Exploring lifelong overactive bladder: Transitions, evidence, and clinical implications; A modified Delphi process

Bou Kheir,

Verbakel,

Vande Walle

et al. 2024

Neurourology and Urodynamics

View full text Add to dashboard Cite

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Review of the Impact and Burden of Urinary Urgency on Adults with Overactive Bladder

Wagg,

Ackerman,

Lai

et al. 2024

International Journal of Clinical Practice

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Overactive bladder (OAB) is a prevalent condition that impairs the quality of life in both men and women, and for many, urgency is the most bothersome symptom. Urgency is thought to drive the presentation of the other symptoms (frequency, nocturia, urgency urinary incontinence [UUI]). However, urgency has been understudied in clinical trials, potentially owing to inherent difficulties in its assessment. The definition of urgency related to OAB has been refined over the years, but it may not be easily understood by patients and clinicians, affecting its use in practice. Variability among the tools to measure urgency further complicates the matter. For example, some measure the frequency of urgency episodes and consider reduction of episode frequency as improvement in urgency severity. Others rate the severity of each episode of urgency along a scale, with some including an accompanying incontinence episode as the most severe form. Reduction in UUI episodes is often a primary endpoint in clinical studies, with many studies requiring UUI—sometimes called OAB‐wet—as an inclusion criterion, yet approximately two‐thirds of those with OAB do not experience UUI. If patients with OAB without UUI (i.e., OAB‐dry) are included, they are often not analyzed separately. Thus, it remains unknown if there are differences in treatment outcomes between patients with and without UUI and whether these differences are driven by pathophysiological processes. This narrative review highlights what is known about the pathophysiology of urgency, how urgency affects individuals with OAB, urgency measurement and associated challenges, and assessment of urgency in clinical trials.

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When Did They Start? Age of Onset of Toileting Behaviors and Urinary Cues as Reported by Older Women

Cited by 2 publications

References 27 publications

Exploring lifelong overactive bladder: Transitions, evidence, and clinical implications; A modified Delphi process

Exploring lifelong overactive bladder: Transitions, evidence, and clinical implications; A modified Delphi process

Review of the Impact and Burden of Urinary Urgency on Adults with Overactive Bladder

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