When and how to evaluate mildly elevated liver enzymes in apparently healthy patients

Abstract

Because 1% to 9% of people without symptoms have elevated liver enzymes, extensive evaluation of all abnormal test results would expose many patients to undue risks and expenses. On the other hand, failure to evaluate minor liver enzyme elevations could mean missing the early diagnosis of potentially treatable disorders. This review discusses likely causes of elevated aminotransferase, alkaline phosphatase, and gamma-glutamyl transferase levels and provides algorithms for evaluating high liver enzyme values in apparently healthy patients in the primary care setting.

Consumption of soft drinks and juices and risk of liver and biliary tract cancers in a European cohort

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Curcumin Attenuates Hepatotoxicity Induced by Zinc Oxide Nanoparticles in Rats

“…The serum activity of these enzymes is routinely measured for the detection of liver disorders (19). The liver cells release these enzymes into the blood stream following injury or death.…”

Serum Carbohydrate Deficient Transferrin as a Sensitive Marker in Diagnosing Alcohol Abuse: A Case Control Study

“…As per literature, false positive results are more prevalent in identifying alcohol abuse because coffee consumption can also reduce the percent of alcohol biomarkers (ALT/AST) [3]. Also diabetes can elevate the %CDT in the blood [4].Themeasures to overcome false positive is not discussed in the study.…”